18,093 research outputs found

    Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

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    The final published version can be found here: http://dx.doi.org/10.1073/pnas.1411390111M.C. is the recipient of a Bennett Fellowship from Leukaemia and Lymphoma Research (ref. 12002). M.A.B. is supported by a GlaxoSmithKline Oncology–Biotechnology and Biological Sciences Research Council Collaborative Awards in Science and Engineering PhD studentship. This work was supported by National Institutes of Health Grants GM087507 and GM102336 (to T.E.D.)

    Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory

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    Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we discuss recent electrophysiological findings that offer an alternate view of hippocampal and medial entorhinal function. These findings suggest complementary contributions of the hippocampus and medial entorhinal cortex in support of episodic memory, wherein hippocampal networks encode sequences of events that compose temporally and spatially extended episodes, whereas medial entorhinal networks disambiguate overlapping episodes by binding sequential events into distinct memories.National Institute of Mental Health Grants (MH51570, MH071702); National Science Foundation (Science of Learning Center grant SBE-0354378

    High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection

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    Acknowledgments The authors thank M. Robertson and R. Fordyce for technical support during the duration of the study. The work performed in Aberdeen was supported by grant from Action Medical Research UK (SP4328; London, England, UK), NHS Grampian Endowment grant (12/49; Aberdeen, Scotland, UK), and Saving Sight in Grampian (Charity No.SC002938; Aberdeen, Scotland, UK). The work performed in Pittsburgh was supported by a Fight for Sight Post-Doctoral Award (JEK; New York, NY, USA); unrestricted grants from the Western Pennsylvania Medical Eye Bank Foundation (Pittsburgh, PA, USA), Research to Prevent Blindness (New York, NY, USA), and the Eye and Ear Foundation of Pittsburgh (RLH; Pittsburgh, PA, USA); and National Institutes of Health Grants P30EY08098 (RLH; Bethesda, MD, USA) and EY10359 (RLH).Peer reviewedPublisher PD

    Obesity : an evolutionary context

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    This work was supported by the Shenzhen Key Laboratory of Metabolic Health (ZDSYS20210427152400001) to JRS and by the US National Institutes of Health grants R01DK100659, R01DK118725, P01DK119130 and R01DK12724 to JKE.Peer reviewedPublisher PD

    Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

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    ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S. degree requirements from Northeastern University, Boston, MA.Peer reviewedPublisher PD

    Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

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    National Institutes of Health grants GM-38765 and P50-DE016191 (C.N.S.), Welcome Trust Programme grant 086867/Z/08/Z (R.J.F. and M.P.) and Project grant 085903/Z/08 (R.J.F.) and Arthritis Research Campaign UK fellowships 18445 and 18103 (to L.V.N. and D.C., respectively). M.S. received a National Research Service Award from the NHLBI (HL087526)

    Neurophysiology

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    Contains reports on four research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grants MH-04737-03 and NB-04985-01)United States Air Force, Aeronautical Systems Division (Contract AF33(616)-7783)United States Air Force (Contract AF19(604)-6619), administered by Montana State CollegeNational Aeronautics and Space Administration (Grant NsG-496)Teagle Foundation, IncorporatedBell Telephone Laboratories, Incorporate

    What Influences Federal Allocation of Behavioral Health Grants: Evidence from the United States

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    Subnational government entities benefit from federal funds to support programs and operations. There are a variety of factors that influence federal grant funds to recipients. This study seeks to identify the effects of multiple factors on federal grant allocation from the Substance Abuse and Mental Health Services Administration (SAMHSA) to state entities. The literature suggests three categories of factors affecting federal funding distribution, including problem severity and need, recipient capacity, and political motivation. I conduct a regression analysis to test the effects of these factors, using a pooled cross-sectional time-series data set. The results indicate that political motivation has a significant influence on federal grant distribution, primarily through representation in the House of Representatives majority party. These results help to explain the disparity in federal grant distribution and the factors that influence funding
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