1,304 research outputs found
Detecting the Optic Disc and Optic Cup Boundary for Glaucoma Screening A Review
Glaucoma is the leading cause of irreversible blindness in the world. Assessment of damaged optic nerve head is both more promising, and superior to IOP measurement or visual field testing for glaucoma screening. This paper present here the automatic glaucoma screening using CDR from 2 D fundus images using superpixel classification. . We compute centre surround statistics from super pixels and unify them with histograms for disc and cup segmentation. Based on the segmented disc and cup, CDR is computed for glaucoma screening. In addition, the proposed method computes a self - assessment reliability score for its disc segmentation result
OCT for glaucoma diagnosis, screening and detection of glaucoma progression.
Optical coherence tomography (OCT) is a commonly used imaging modality in the evaluation of glaucomatous damage. The commercially available spectral domain (SD)-OCT offers benefits in glaucoma assessment over the earlier generation of time domain-OCT due to increased axial resolution, faster scanning speeds and has been reported to have improved reproducibility but similar diagnostic accuracy. The capabilities of SD-OCT are rapidly advancing with 3D imaging, reproducible registration, and advanced segmentation algorithms of macular and optic nerve head regions. A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection of progression while initial studies of macular and optic nerve head parameters have shown promising results. SD-OCT still currently lacks the diagnostic performance for glaucoma screening
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Development and validation of a new glaucoma screening test using temporally modulated flicker
Purpose
Describing the psychometric characteristics and diagnostic accuracy of the Accelerator 4âAlternative ForcedâChoice Flicker Test prototype (A4FTp) for detecting chronic open angle glaucoma (COAG).
Methods
A4FTp measures temporallyâmodulated flicker thresholds in regions of the visual field with high susceptibility to glaucomatous loss. We initially evaluated its psychometric properties on 20 normals (aged 33.8 ± 8.5 years) who were tested multiple times over a period of 3 months. All subjects underwent four repetitions for shorter (T8) and longer (T12) staircase termination criteria, to determine the most suitable threshold criterion. Four randomly selected subjects underwent a total of 10 repetitions to study testâretest repeatability and learning effects. To determine its diagnostic accuracy, one eye of 40 participants with COAG and 38 normal controls were tested with the A4FTp in comparison with the Frequency Doubling Technology (FDT; C20â5 programme) and iVue Spectral Domain Optical Coherence Tomography (SDâOCT). Tests were conducted in a random order with results masked to the clinician conducting the reference ophthalmic examination. The accuracy of each test was determined by analysis of the area under the receiver operator characteristic curve (AUROC).
Results
A4FTp flicker thresholds were stable, with standard deviations of only 0.52 decilog (dL) for T8, increasing to 1.32 dL for T12, and no significant flicker sensitivity threshold improvement over the 10 repeat runs. T8 was superior to T12 on several other measures, so it was used for the remaining comparisons. In terms of diagnostic accuracy, the mean AUROC for the three tests were A4FTp [T8 criterion; 0.82, 95% confidence interval (0.73â0.92)]; SDâOCT [any RNFL parameter p < 1% level; 0.90 (0.83â0.97)]; and FDT [one or more locations missed at p < 5% level; 0.91 (0.82â0.96)]. There was no statistical difference in AUROC between A4FTp and SDâOCT (p = 0.18) or FDT (p = 0.12). The A4FTp test duration averaged just over 2 min per eye, taking approximately oneâthird of the time for completion of the HFA SITA 24â2 algorithm (conducted as part of the reference examination) and twice the time for the suprathreshold FDT.
Conclusion
Test accuracy for the A4FTp was comparable to those of the FDT and SDâOCT for the detection of COAG. Time taken to complete the A4FTp was relatively short and initial results are promising. With further refinement, the A4FTp could have a future role in glaucoma detection
Campus Update: March 1990 v. 2, no. 3
Monthly newsletter of the BU Medical Campu
Campus Update: April 1990, v. 2, no. 4
Monthly newsletter of the BU Medical Campu
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