2 research outputs found
Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans
[EN]The aim of this work was to evaluate the biological activity of four grape pomace (GP)
extracts that are rich in polyphenols using C. elegans as an in vivo model. Different concentrations of
the GP extracts were assessed for their effects on the resistance of C. elegans against thermally induced
oxidative stress, accumulation of reactive oxygen species (ROS), and lifespan. The cultivation of
C. elegans with relatively low concentrations of GP extracts increased their resistance against thermal
stress and prolonged their lifespan, while high levels displayed detrimental effects. In the studied
extracts, maximum protection was observed for levels of polyphenols around 7 to 9 µg gallic acid
equivalents per cultivation plate. The obtained results suggested that small changes in the ROS levels
could have beneficial effects, although further studies are required to fully understand the impact
of the extracts and assayed doses on ROS levels to explain the mechanism that is involved in the
observed effects