Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.This research has been supported by the Project 201770E081 from the Spanish National Research Council (CSIC, Spain) and by the Project AGL2015-64124-R (Ministry of Science, Innovation and Universities, Spain). J. A. G.-B. is a holder of a “Juan de la Cierva” contract from the Ministry of Science, Innovation and Universities (Spain).We acknowledge support of the publication fee by the CSIC Open Access Support Initiative through its Unit of Information Resources for Research (URICI)Peer reviewe