CholesteroNitrones for Stroke

This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke. (Figure Presented).A.A. thanks M. Gómez-Calcerrada and Valerio Frezza for their technical assistance. This work was supported by ISCIII and FEDER grants to A.A. (PI1/00334 and PI14/00705).Peer Reviewe