Maximin optimal designs for the compartmental model

For the compartmental model we determine optimal designs, which are robust against misspecifications of the unknown model parameters. We propose a maximin approach based on D-efficiencies and provide designs that are optimal with respect to the particular choice of various parameter regions. --Compartmental model,robust optimal design,maximin Doptimality,local optimality

A Stochastic Compartmental Model for Fast Axonal Transport

In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons. By directly modeling the smallest scale interactions, we can use recent microscopic experimental observations to infer all the parameters of the model. Then, using techniques from probability theory, we compute asymptotic limits of the stochastic behavior of individual motor-cargo complexes, while also characterizing both equilibrium and non-equilibrium ensemble behavior. We use these results in order to investigate three important biological questions: (1) How homogeneous are axons at stochastic equilibrium? (2) How quickly can axons return to stochastic equilibrium after large local perturbations? (3) How is our understanding of delivery time to a depleted target region changed by taking the whole cell point-of-view

Spearman simultaneous estimation for a compartmental model Technical report no. 9

Compartmental model, represented as system of linear combination of exponentials with common exponential parameters, for tracer experiment

A Compartmental Model for Traffic Networks and its Dynamical Behavior

We propose a macroscopic traffic network flow model suitable for analysis as a dynamical system, and we qualitatively analyze equilibrium flows as well as convergence. Flows at a junction are determined by downstream supply of capacity as well as upstream demand of traffic wishing to flow through the junction. This approach is rooted in the celebrated Cell Transmission Model for freeway traffic flow. Unlike related results which rely on certain system cooperativity properties, our model generally does not possess these properties. We show that the lack of cooperativity is in fact a useful feature that allows traffic control methods, such as ramp metering, to be effective. Finally, we leverage the results of the paper to develop a linear program for optimal ramp metering

A Note on the Trandermal Delivery of Clenbuterol

A modified diffusion/compartmental model has been used to simulate the transdermal uptake of clenbuterol from a matrix-type delivery device. The application of a fresh device every 7 days was found to produce a pseudo-steady state drug plasma profile after approx. three changes of device. Of the matrix properties, only drug loading had substantial effect on the drug plasma profile

Dynamic modelling of hepatitis C virus transmission among people who inject drugs: a methodological review

Equipment sharing among people who inject drugs (PWID) is a key risk factor in infection by hepatitis C virus (HCV). Both the effectiveness and cost-effectiveness of interventions aimed at reducing HCV transmission in this population (such as opioid substitution therapy, needle exchange programs or improved treatment) are difficult to evaluate using field surveys. Ethical issues and complicated access to the PWID population make it difficult to gather epidemiological data. In this context, mathematical modelling of HCV transmission is a useful alternative for comparing the cost and effectiveness of various interventions. Several models have been developed in the past few years. They are often based on strong hypotheses concerning the population structure. This review presents compartmental and individual-based models in order to underline their strengths and limits in the context of HCV infection among PWID. The final section discusses the main results of the papers