13,359 research outputs found

    Activity of aztreonam/avibactam and ceftazidime/avibactam against Enterobacterales with carbapenemase-independent carbapenem resistance

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    Enterobacterales with carbapenemase-independent resistance to carbapenems are sometimes being selected during therapy and, on rare occasions, cause outbreaks. Most have extended-spectrum or AmpC Ī²-lactamases together with changes to permeability or penicillin-binding proteins (PBPs). Newer Ī²-lactam-Ī²-lactamase inhibitor combinations may present useful options for infections due to these organisms. Accordingly, we used CLSI/EUCAST broth-microdilution to measure MICs of ceftazidime/avibactam and aztreonam/avibactam for 51 carbapenemase/negative Enterobacterales with resistance or reduced susceptibility to carbapenems and undertook genomic sequencing of the least-susceptible organisms. MICs of the two avibactam combinations MICs cross-correlated closely, but with fewer MICs (2/51 versus 10/51) exceeding 8+4 mg/L in the case of ceftazidime/avibactam. Raised MICs for Escherichia coli were associated PBP3 inserts together with CMY-42 Ī²-lactamase; correlates among Enterobacter cloacae complex isolates remain elusive, with AmpC and PBP3 sequences found to be sub-species specific. In the case of Klebsiella spp. no MICs exceeding 2 mg/L were seen for either combination. We conclude that these avibactam combinations have potential against Enterobacterales with carbapenemase-independent carbapenem resistance or reduced susceptibility, with ceftazidime/avibactam the more reliably active

    sj-docx-1-cde-10.1177_21651434231221493 ā€“ Supplemental material for Family Service Use and Outcomes for Youth With Disabilities

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    Supplemental material, sj-docx-1-cde-10.1177_21651434231221493 for Family Service Use and Outcomes for Youth With Disabilities by Michael Levere, Todd Honeycutt, Gina Livermore, Arif Mamun and Karen Katz in Career Development and Transition for Exceptional Individuals</p

    Climatological predictions of the auroral zone locations driven by moderate and severe space weather events

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    Auroral zones are regions where, in an average sense, aurorae due to solar activity are most likely spotted. Their shape and, similarly, the geographical locations most vulnerable to extreme space weather events (which we term ā€˜danger zonesā€™) are modulated by Earthā€™s time-dependent internal magnetic field whose structure changes on yearly to decadal timescales. Strategies for mitigating ground-based space weather impacts over the next few decades can benefit from accurate forecasts of this evolution. Existing auroral zone forecasts use simplified assumptions of geomagnetic field variations. By harnessing the capability of modern geomagnetic field forecasts based on the dynamics of Earthā€™s core we estimate the evolution of the auroral zones and of the danger zones over the next 50 years. Our results predict that space-weather related risk will not change significantly in Europe, Australia and New Zealand. Mid-to-high latitude cities such as Edinburgh, Copenhagen and Dunedin will remain in high-risk regions. However, northward change of the auroral and danger zones over North America will likely cause urban centres such as Edmonton and Labrador City to be exposed by 2070 to the potential impact of severe solar activity

    Table_2_Beyond discards: cascading socio-economic and environmental effects of a commercial aggregate landings program in Rhode Island.docx

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    Flexible approaches to commercial fisheries harvest have been designed to meet management objectives. Rights-based management tools have been problematic for fishing businesses in certain scenarios, whereas aggregate landings approaches may offer similar flexibility while avoiding pitfalls like industry consolidation. This study evaluates a Rhode Island pilot aggregate landings program for summer flounder (Paralichthys dentatus) and black sea bass (Centropristis striata) from the perspective of the pilot program participants. Semi-structured interviews were conducted with participating commercial harvesters. Fishery-dependent data were also analyzed to supplement harvestersā€™ responses. Interview respondents overwhelmingly supported the aggregate landings approach and described benefits directly from the program, including cost savings, reduced discards, and improved safety. TheĀ program also led to increased average weekly harvest of both species and a slight increase in the price of catch for black sea bass for program participants. The aggregate landings approach encouraged fishers to take on less risk through added flexibility in when they chose to fish, while still maximizing their utility. Although the original goals of the program were to reduce regulatory discards and make businesses more efficient, it also resulted in improvements to fishersā€™ well-being, suggesting that aggregate landings approaches should be considered for other fisheries.</p

    Allan_BioDigiCon2023.pptx

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    As we enter the tenth year of the Digital Collections Programme at the Natural History Museum, London we have seen an increase in the scale and diversity of our mass digitisation activities, with almost 1.15 million objects digitised from 45 projects across 14 different collection and preservation types.Ā The digitisation team began with two staff members but rapidly increased, over a two year period, to seven, ultimately reaching nine members a few years later. This increase in team size meant we had greater capacity to run simultaneous projects, expand digitisation activities to include collections with more complex needs, expand team knowledge through training, be more reactive to external funding opportunities, support more public engagement activities etc.Ā With this increase in the programmeā€™s activities, outputs and resources, there was also an increase in the volume and complexity of our documentation, which we had to ensure would remain sustainable, and relevant, over time without becoming arduous.Ā In this talk we share and discuss some of the processes and approaches that we have found most effective: Continually review documents and the documenting process, making improvements where necessary; Standardise documentation across projects and activities by using templates for routine documentation, i.e. project proposals, output recording sheets, reports, datasets etc.; Master files with key information, such as an overview, with metrics, for completed, active and future projects, a risks and issues log etc.; Automate metric capture for use in project monitoring, forecasting, output reporting etc.; Reduce redundancy wherever possible.</p

    Table_1_Beyond discards: cascading socio-economic and environmental effects of a commercial aggregate landings program in Rhode Island.docx

    No full text
    Flexible approaches to commercial fisheries harvest have been designed to meet management objectives. Rights-based management tools have been problematic for fishing businesses in certain scenarios, whereas aggregate landings approaches may offer similar flexibility while avoiding pitfalls like industry consolidation. This study evaluates a Rhode Island pilot aggregate landings program for summer flounder (Paralichthys dentatus) and black sea bass (Centropristis striata) from the perspective of the pilot program participants. Semi-structured interviews were conducted with participating commercial harvesters. Fishery-dependent data were also analyzed to supplement harvestersā€™ responses. Interview respondents overwhelmingly supported the aggregate landings approach and described benefits directly from the program, including cost savings, reduced discards, and improved safety. TheĀ program also led to increased average weekly harvest of both species and a slight increase in the price of catch for black sea bass for program participants. The aggregate landings approach encouraged fishers to take on less risk through added flexibility in when they chose to fish, while still maximizing their utility. Although the original goals of the program were to reduce regulatory discards and make businesses more efficient, it also resulted in improvements to fishersā€™ well-being, suggesting that aggregate landings approaches should be considered for other fisheries.</p

    Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search

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    Introduction Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growing interest in finding alternatives to steroids but there is little formal study of animal models of peritumoral brain edema. This study aims to summarize the available literature. Methods A systematic search was undertaken of 5 literature databases (Medline, Embase, CINAHL, PubMed and the Cochrane Library). The generic strategy was to search for various terms associated with ā€œbrain tumorsā€, ā€œbrain edemaā€ and ā€œanimal modelsā€. Results We identified 603 reports, of which 112 were identified as relevant for full text analysis that studied 114 peritumoral brain edema animal models. We found significant heterogeneity in the species and strain of tumor-bearing animals, tumor implantation method and edema assessment. Most models did not produce appreciable brain edema and did not test for observable manifestations thereof. Conclusion No animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models

    Beyond discards: cascading socio-economic and environmental effects of a commercial aggregate landings program in Rhode Island

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    Flexible approaches to commercial fisheries harvest have been designed to meet management objectives. Rights-based management tools have been problematic for fishing businesses in certain scenarios, whereas aggregate landings approaches may offer similar flexibility while avoiding pitfalls like industry consolidation. This study evaluates a Rhode Island pilot aggregate landings program for summer flounder (Paralichthys dentatus) and black sea bass (Centropristis striata) from the perspective of the pilot program participants. Semi-structured interviews were conducted with participating commercial harvesters. Fishery-dependent data were also analyzed to supplement harvestersā€™ responses. Interview respondents overwhelmingly supported the aggregate landings approach and described benefits directly from the program, including cost savings, reduced discards, and improved safety. TheĀ program also led to increased average weekly harvest of both species and a slight increase in the price of catch for black sea bass for program participants. The aggregate landings approach encouraged fishers to take on less risk through added flexibility in when they chose to fish, while still maximizing their utility. Although the original goals of the program were to reduce regulatory discards and make businesses more efficient, it also resulted in improvements to fishersā€™ well-being, suggesting that aggregate landings approaches should be considered for other fisheries

    Table_4_Beyond discards: cascading socio-economic and environmental effects of a commercial aggregate landings program in Rhode Island.docx

    No full text
    Flexible approaches to commercial fisheries harvest have been designed to meet management objectives. Rights-based management tools have been problematic for fishing businesses in certain scenarios, whereas aggregate landings approaches may offer similar flexibility while avoiding pitfalls like industry consolidation. This study evaluates a Rhode Island pilot aggregate landings program for summer flounder (Paralichthys dentatus) and black sea bass (Centropristis striata) from the perspective of the pilot program participants. Semi-structured interviews were conducted with participating commercial harvesters. Fishery-dependent data were also analyzed to supplement harvestersā€™ responses. Interview respondents overwhelmingly supported the aggregate landings approach and described benefits directly from the program, including cost savings, reduced discards, and improved safety. TheĀ program also led to increased average weekly harvest of both species and a slight increase in the price of catch for black sea bass for program participants. The aggregate landings approach encouraged fishers to take on less risk through added flexibility in when they chose to fish, while still maximizing their utility. Although the original goals of the program were to reduce regulatory discards and make businesses more efficient, it also resulted in improvements to fishersā€™ well-being, suggesting that aggregate landings approaches should be considered for other fisheries.</p
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