30,899 research outputs found

    Quasi-local Update Algorithms for Numerical Simulations of d=3 SU(2) LGT in the Dual Formulation

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    In the dual formulation of d=3 SU(2) LGT, the link variables are group representations and valid configurations are those satisfying a number of triangle inequalities. In \cite{lat99} algorithms for local updates that automatically respect these constraints were described. It was also pointed out there that these local updates were not ergodic. In this presentation, we describe two different quasi-local updating algorithms which, in conjunction with the local updates, appear to be ergodic.Comment: LATTICE2000(Topics in Gauge Theories),5 pages,5 figures,LaTe

    Analytic Variational Investigation of Euclidean SU(3) Gauge Theory

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    Analytic variational techniques for lattice gauge theories based on the Rayleigh-Ritz(RR) method were previously developed for euclidean SU(2) gauge theories in 3 and 4 dimensions. Their extensions to SU(3) gauge theory including applications to correlation functions and mass gaps are presented here.Comment: 4-pages in 2-column format, typsetted for LaTeX with document style espcrc2.sty (available on request), IMSc/93-2

    Depression in Low-Income Adolescents: Guidelines for School-Based Depression Intervention Programs

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    Adolescent depression is growing in interest to clinicians. In addition to the estimated 2 million cases of adolescent major depressive episodes each year, depressive symptoms in youth have become indicators of mental health complications later in life. Studies indicate that being low-income is a risk factor for depression and that socioeconomically disadvantaged teenagers are more than twice as likely to develop mental illnesses. Only an estimated 1 in 4 children with mental illnesses receive adequate help and 80% of these resources come through schools. Thus, this study focuses on establishing the importance of depression intervention programs in low-income high schools and designing novel guidelines for effective protocols. A compilation of expert opinion on depression screening, education, and treatment, as well as analysis of previously implemented school screening and awareness programs, are examined in order to understand key strategies. The results of this study finds that a multi-layered approach with screening, universal education, and interventions for those identified as being high-risk is most effective in addressing the mental health needs of low-income adolescents. To ensure feasibility and efficacy, screening should be conducted with a modified PHQ-a test and followed-up by timely clinical interviews by school psychologists. All students should receive universal depression education curriculum consisting of principles such as: depression literacy, asset theory, and promotion of help-seeking behaviors. Extending universal education to teachers would also be beneficial in promoting mental health communication and positive classroom environments. It is vital that those screening positive for depression or suicidality receive protocols geared towards high-risk youths, such as group Cognitive-Behavioral Therapy and facilitated mental health center referrals based on individual severity. Effectively addressing depression in school systems requires integration of mental health promotion, depression prevention, and psychotherapy—by taking this multidimensional approach, public health officials and school administrations can ensure that adequate resources are directed to those most in need

    Effects of HIV and Drugs of Abuse on the Blood-Brain Barrier

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    Despite effective systemic therapy, HIV-1 infection within the brain results in neuronal degradation and neurocognitive dysfunction. This neurocognitive dysfunction is worsened in the setting of opiate abuse. The central nervous system (CNS) is protected by the blood-brain barrier (BBB), a selective barrier regulating the passage of substances from peripheral circulation into the CNS. The BBB is composed of microvascular endothelial cells encased by basal lamina, pericytes, and perivascular astrocyte endfeet. Intracellular junctional complexes comprising of adherens and tight junctions are located between the endothelial cells and form tight barrier, preventing traffic of compounds between cells (paracellular flux). Clinical and in vitro data suggest that BBB integrity is compromised in HIV infection, which leads to a leaky barrier. Brain microvascular endothelial cells also express efflux transporters that are responsible for the extrusion of substances from the brain back into the blood. P-glycoprotein is a drug efflux transporter involved in the efflux of many antiretroviral drugs and overexpression of P-glycoprotein can limit therapeutic concentrations of substrate drugs within the brain. Additionally, P-glycoprotein expression and/or function may be altered in the setting of HIV infection and in the setting of drug abuse. In order to study the impact of morphine, a commonly used opiate drug of abuse, on drug-efflux proteins at the BBB, we measured the effects of morphine and the HIV-1 protein Tat on P-glycoprotein expression and function. hCMEC/D3 cells, which are human derived brain microvascular endothelial cells, were pre-treated for 24 hours with Tat (100nM), morphine (500nM), or Tat (100nM) + morphine (500nM). P-glycoprotein function was evaluated by measuring intracellular accumulation of the prototypical P-glycoprotein substrate, rhodamine-123. Compared to control, statistically significant increases in cellular accumulation of rhodamine-123 were observed in both the morphine (mean±SEM; 118±6.5%, p\u3c0.05) and Tat+morphine (118 ±13.1%, p\u3c0.05) groups, suggesting decreased efflux activity of P-glycoprotein. Protein expression of P-glycoprotein was measured using western blot analysis. Significant decreases in P-glycoprotein expression was observed in all treatment groups as compared to control; Tat (63±4.2%, p\u3c 0.05), morphine (64±13.5%, p\u3c0.05) and Tat+morphine (69±15.6%, p\u3c0.05). Understanding the factors that influence efflux transporter function and expression in the BBB are crucial in optimizing antiretroviral penetration into the brain, even in the setting of drug abuse.https://scholarscompass.vcu.edu/uresposters/1263/thumbnail.jp

    MAP OF THE TRANS JOGJA BASED MICROCONTROLLER ATmega 32

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    Trans Jogja is one means of ground transportation is located in Yogyakarta, which operate using certain routes so as to not raise and lower the passengers. Passengers who will use Trans Jogja should use The already provided on each line. But not every Stop there are means of information that shows the paths traversed, for a while at the bus stop just use a map. So it is not yet able to provide information to its full potential. At the end of the project is the author of designing maps more interactive so that users are more helpful for Trans Jogja.The advantages of Map Trans Jogja Route is to take the map using electronic circuits work simultaneously. In making a map of The Trasnjogja-based Microcontroller ATmega 32 consists of several stages, namely: (1) identification of needs, (2) analysis of needs, (3) concept design, (4) and (5) testing. This tool is composed of software and hardware.The software consists of basic language with BASCOM. The hardware using catudaya 5 volt DC system with minimum, ATmega 32 as an indicator LED, LCD, as the Viewer output. This tool works with a voltage of 5 volt supplay which flows from the catudaya series minimum system for mensupplay LED and LCD. In addition, there are 6 key push button that serves as the command input, while for LCDs and LEDs as outputs. Six buttons on this tool serves as a special line of Trans Jogja that has endured and the menu reset, for Trans Jogja line menu consists of 1A, 1B, 2A, 2B. 3A, 3B. From the menu there is a line that has the same Trans Jogja bus such as line 1A there is a bus stop where the lines of 1B so that there are 64 stops Trans Jogja that has endured. This tool works as planned, run the command pushbutton, and then processed in the ATmega Microcontroller 32 and issuing output through the LCD and LED indicators. The LCD and LEDS are enabled as a guide line and hints of the existence of the site.With inisemoga Trans Jogja users more easily get information more clear and optimal. Keywords: ATmega Microcontroller 32, Map the Trans Jogja

    Menentukan pembagi nol pada matriks aas ring komutatif dengan teorema cayley-hamilton

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    Tulisan ini membahas pembagi nol pada matriks berukuran nxn yang elemen-elemennya berasal dari ring komutatif R yang dilambangkan dengan Mrsmn(R). Pertama pembahasan teori penunjang meliput ring, ring polinomial, matriks invertibel, polinomial matriks dan teorema Cayley-Hamilton, dilanjutkan dengan teorema-teorema tentang pembagi nol pada matriks atas ring komutatif Dengan menggunakan teorema-teorema tentang pembagi dapat diselidiki suatu matriks atas ring komutatif merupakan suatu pembagi nol dan dengan teorema Cayley-Hamilton dikonstruksi suatu polinomial g(A)ER[A] sedemikian sehingga Ag(A) = g(A)A = 0. This paper discusses zero divisors in matrices size nxn with entries from a commutative ring, denoted by M.(R). Some basic concepts will be reviewed including ring, polynomial ring, invertible matrices, polynomial matrices and the Cayley-Hamilton theorem. Finally the discussion continues to zero divisors. A€ 3.4.(R) is a zero divisor is observed using some theorem about zero divisor and using Cayley-Hamilton theorem a polynomial g(A)EZ{Ri is constructed in such Ag(A) = g(A)A = 0

    Current Status of the Numerical Simulations of d=3 SU(2) Lattice Gauge Theory in the Dual Formulation

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    We have continued our systematic investigations of the numerical simulations of lattice gauge theories in the dual formulation. These include: i) a more practical implementation of the quasi-local updating technique, ii) a thorough investigation of the sign problem, iii) issues related to the ergodicity of the various update algorithms, iv) a novel way of measuring conventional observables like plaquette in the dual formalism and v) investigations of thermalisation. While the dual formulation holds out a lot of promises in principle, there are still some ways to go before it can be made into an attractive alternative lattice formulation.Comment: LATTICE2000(Topics in Gauge Theories),5 pages,3 figures,LaTex(espcrc2.sty
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