993 research outputs found

    Discarded livers tested by normothermic machine perfusion in the VITTAL trial:Secondary end points and 5-year outcomes

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    Normothermic machine perfusion (NMP) enables pretransplant assessment of high-risk donor livers. The VITTAL trial demonstrated that 71% of the currently discarded organs could be transplanted with 100% 90-day patient and graft survivals. Here, we report secondary end points and 5-year outcomes of this prospective, open-label, phase 2 adaptive single-arm study. The patient and graft survivals at 60 months were 82% and 72%, respectively. Four patients lost their graft due to nonanastomotic biliary strictures, one caused by hepatic artery thrombosis in a liver donated following brain death, and 3 in elderly livers donated after circulatory death (DCD), which all clinically manifested within 6 months after transplantation. There were no late graft losses for other reasons. All the 4 patients who died during the study follow-up had functioning grafts. Nonanastomotic biliary strictures developed in donated after circulatory death livers that failed to produce bile with pH &gt;7.65 and bicarbonate levels &gt;25 mmol/L. Histological assessment in these livers revealed high bile duct injury scores characterized by arterial medial necrosis. The quality of life at 6 months significantly improved in all but 4 patients suffering from nonanastomotic biliary strictures. This first report of long-term outcomes of high-risk livers assessed by normothermic machine perfusion demonstrated excellent 5-year survival without adverse effects in all organs functioning beyond 1 year (ClinicalTrials.gov number NCT02740608).</p

    DES Y3 + KiDS-1000: Consistent cosmology combining cosmic shear surveys

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    International audienceWe present a joint cosmic shear analysis of the Dark Energy Survey (DES Y3) and the Kilo-Degree Survey (KiDS-1000) in a collaborative effort between the two survey teams. We find consistent cosmological parameter constraints between DES Y3 and KiDS-1000 which, when combined in a joint-survey analysis, constrain the parameter S8=σ8Ωm/0.3S_8 = \sigma_8 \sqrt{\Omega_{\rm m}/0.3} with a mean value of 0.790−0.014+0.0180.790^{+0.018}_{-0.014}. The mean marginal is lower than the maximum a posteriori estimate, S8=0.801S_8=0.801, owing to skewness in the marginal distribution and projection effects in the multi-dimensional parameter space. Our results are consistent with S8S_8 constraints from observations of the cosmic microwave background by Planck, with agreement at the 1.7σ1.7\sigma level. We use a Hybrid analysis pipeline, defined from a mock survey study quantifying the impact of the different analysis choices originally adopted by each survey team. We review intrinsic alignment models, baryon feedback mitigation strategies, priors, samplers and models of the non-linear matter power spectrum

    Measurement of the Bs0→Ό+Ό− decay properties and search for the B0â€Żâ†’â€ŻÎŒ+Ό− decay in proton-proton collisions at s=13TeV

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    Measurements are presented of the Bs0→Ό+Ό− branching fraction and effective lifetime, as well as results of a search for the B0→Ό+Ό− decay in proton-proton collisions at s=13TeV at the LHC. The analysis is based on data collected with the CMS detector in 2016–2018 corresponding to an integrated luminosity of 140fb−1. The branching fraction of the Bs0→Ό+Ό− decay and the effective Bs0 meson lifetime are the most precise single measurements to date. No evidence for the B0→Ό+Ό− decay has been found. All results are found to be consistent with the standard model predictions and previous measurements

    Search for Eccentric Black Hole Coalescences during the Third Observing Run of LIGO and Virgo