Vacuum biopsy of the breast

Background. Mammotome is a percutaneous biopsy technique with a large needle, assisted by vacuum aspiration. The single insertion technique allows to collect multiple large tissue samples, which gives a more reliable histological result. The technique can be used under stereotactic, MRl or ultrasound guidance. The technique is used under local anesthesia, on an outpatient basis. Conclusions. Altough it is essentially a diagnostic technique, it has a therapeutic potential in some cases. Recently, the technique has been FDA approved for the removal of benign nodular lesions. Worldwide, over 2 million procedures have already been performed. It has the potential to replace surgical open biopsy, with a similar accuracy and at a lower cost, and it is less invasive

FUSE : a microservice approach to cross-domain federation using docker containers

In crisis situations, it is important to be able to quickly gather information from various sources to form a complete and accurate picture of the situation. However, the different policies of participating companies often make it difficult to connect their information sources quickly, or to allow software to be deployed on their networks in a uniform way. The difficulty in deploying software is exacerbated by the fact that companies often use different software platforms in their existing networks. In this paper, Flexible federated Unified Service Environment (FUSE) is presented as a solution for joining multiple domains into a microservice based ad hoc federation, and for deploying and managing container-based software on the devices of a federation. The resource requirements for setting up a FUSE federation are examined, and a video streaming application is deployed to demonstrate the performance of software deployed on an example federation. The results show that FUSE can be deployed in 10 minutes or less, and that it can support multiple video streams under normal network conditions, making it a viable solution for the problem of quick and easy cross-domain federation

Advanced Musculoskeletal Ultrasound Techniques: What are the applications?

The purpose of this review was to cover technical advances in Musculoskeletal Ultrasound from the viewpoint of the user. The authors of this paper took a critical look at the vast expanse of recent literature and picked out what they judged to be real progress. In that judgement, they were guided by questions that remain unsolved in the realm of bone and joint imaging by ultrasound

Capmatinib for the treatment of non-small cell lung cancer

Introduction: Activation of the MET pathway through MET amplifications or mutations is present in 3-4% of stage IV non-squamous non-small cell lung cancers (NSCLC). High MET amplifications and exon 14 skipping mutations are associated with poor prognosis: new treatments are needed for these patients. Capmatinib is a highly selective, potent small-molecule MET inhibitor with antitumor activity in NSCLC in vitro and in vivo. Areas covered: This article provides an overview of the capmatinib clinical development program in NSCLC, both as monotherapy in NSCLC with a dysregulated MET pathway, and in combination with epidermal growth factor receptor (EGFR) inhibitor therapy in EGFR-mutant NSCLC with MET-based acquired resistance to previous EGFR inhibition. Expert opinion: In the GEOMETRY Mono-1 study, treatment with capmatinib resulted in high response rates in stage IV NSCLC with MET exon 14 skipping mutations, particularly in first line, supporting testing for this biomarker at the time of diagnosis. Durable responses have been reported and results in MET-amplified NSCLC are eagerly anticipated. In EGFR-mutant NSCLC, notable responses have been observed in combination with an EGFR-tyrosine kinase inhibitor (TKI) in case of acquired resistance to EGFR-TKIs based on high MET amplification.status: publishe