Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m2 [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m2 [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m2 with 99 Tc- DTPA

MAGE-C2/CT10 Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer

The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. In most cases, no CT antigen is found in normal tissues, except in testis, making them ideal targets for cancer immunotherapy. A comprehensive analysis of CT antigen expression has not yet been reported in prostate cancer. MAGE-C2/CT-10 is a novel CT antigen. The objective of this study was to analyze extent and prognostic significance of MAGE-C2/CT10 protein expression in prostate cancer. 348 prostate carcinomas from consecutive radical prostatectomies, 29 castration-refractory prostate cancer, 46 metastases, and 45 benign hyperplasias were immunohistochemically analyzed for MAGE-C2/CT10 expression using tissue microarrays. Nuclear MAGE-C2/CT10 expression was identified in only 3.3% primary prostate carcinomas. MAGE-C2/CT10 protein expression was significantly more frequent in metastatic (16.3% positivity) and castration-resistant prostate cancer (17% positivity; p<0.001). Nuclear MAGE-C2/CT10 expression was identified as predictor of biochemical recurrence after radical prostatectomy (p = 0.015), which was independent of preoperative PSA, Gleason score, tumor stage, and surgical margin status in multivariate analysis (p<0.05). MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy. Further, the results suggest MAGE-C2/CT10 as a potential target for adjuvant and palliative immunotherapy in patients with prostate cancer

Guidelines for management of ischaemic stroke and transient ischaemic attack 2008

This article represents the update of the European Stroke Initiative Recommendations for Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic attacks, which are now considered to be a single entity. The article covers referral and emergency management, Stroke Unit service, diagnostics, primary and secondary prevention, general stroke treatment, specific treatment including acute management, management of complications, and rehabilitation

Intervento programmato sulla dimensione collettiva dei big data al Convegno Le categorie giuridiche dinanzi alla sfida dei Big Data, 1/7/2019, Università degli Studi di Napoli Federico II – Napoli (organizzato dalla prof.ssa Giovanna De Minico e dal prof. Giuseppe Guizzi).

L'intervento indaga l'emersione di una dimensione collettiva del diritto alla privacy alla luce dei cambiamenti dovuti all'epoca dei big dat

Relazione alla GIG-ARTS Conference 2017 – 30-31 March 2017, Paris, Global Internet Governance as a Diplomacy Issue (chair prof. Meryem Marzouki), con G. Micciarelli, su Digital Rights and Market in Free Trade Agreements.

L'intervento approfondisce - attraverso il caso di studio del TISA - la disciplina dei big data nei trattati di libero scambio di nuova generazione, evidenziando il rispettivo ruolo dei diritti fondamentali e della tutela del libero mercato

Relazione al IV Convegno internazionale del Seminario Italo-spagnolo, 28-30 novembre 2018 presso la Facultad de Derecho de la Universidad de Murcia - Campus de La Merced, su Il voto elettronico tra valori costituzionali e disegno partecipativo delle tecnologie.

L'intervento si sofferma su raccomandazioni giuridiche riguardanti il voto elettronico, alla luce di una corretta identificazione e applicazione dei valori costituzionali sul voto e la partecipazione politica

Partecipazione con scholarship al World Youth Forum for Ethics in Innovation 2017, 23-27 giugno 2017, Munich (organizzato dal World Forum for Ethics in Business (WFEB) con il Max Planck Institute for Innovation and Competition (MPI) e la Peter Löscher Chair of Business Ethics, Technical University of Munich), con un case study riguardante il progetto MappiNA – Mappa alternativa della città.

Nel corso dell'evento è stato discusso il tema delle tecnologie FLOSS di partecipazione politica, a partire da un case study riguardante il progetto MappiNA – Mappa alternativa della città