Malaria and Fetal Growth Alterations in the 3(rd) Trimester of Pregnancy: A Longitudinal Ultrasound Study.

Pregnancy associated malaria is associated with decreased birth weight, but in-utero evaluation of fetal growth alterations is rarely performed. The objective of this study was to investigate malaria induced changes in fetal growth during the 3(rd) trimester using trans-abdominal ultrasound. An observational study of 876 pregnant women (398 primi- and secundigravidae and 478 multigravidae) was conducted in Tanzania. Fetal growth was monitored with ultrasound and screening for malaria was performed regularly. Birth weight and fetal weight were converted to z-scores, and fetal growth evaluated as fetal weight gain from the 26th week of pregnancy. Malaria infection only affected birth weight and fetal growth among primi- and secundigravid women. Forty-eight of the 398 primi- and secundigravid women had malaria during pregnancy causing a reduction in the newborns z-score of -0.50 (95% CI: -0.86, -0.13, P = 0.008, multiple linear regression). Fifty-eight percent (28/48) of the primi- and secundigravidae had malaria in the first half of pregnancy, but an effect on fetal growth was observed in the 3(rd) trimester with an OR of 4.89 for the fetal growth rate belonging to the lowest 25% in the population (95%CI: 2.03-11.79, P<0.001, multiple logistic regression). At an individual level, among the primi- and secundigravidae, 27% experienced alterations of fetal growth immediately after exposure but only for a short interval, 27% only late in pregnancy, 16.2% persistently from exposure until the end of pregnancy, and 29.7% had no alterations of fetal growth. The effect of malaria infections was observed during the 3(rd) trimester, despite infections occurring much earlier in pregnancy, and different mechanisms might operate leading to different patterns of growth alterations. This study highlights the need for protection against malaria throughout pregnancy and the recognition that observed changes in fetal growth might be a consequence of an infection much earlier in pregnancy.\u

The Empire that was always Decaying: The Carolingians (800-888). Medieval Worlds|Empires: Elements of Cohesion and Signs of Decay medieval worlds Volume 2015.2|

This paper examines the potency of the concept of ›empire‹ in Carolingian history, arguing against the still recent trend in medieval studies of seeing the Carolingian empire as having been in a constant state of decay. An initial historiographical overview of medievalist’s perceptions of ›empire‹ over the past century is followed by a discussion of how Carolingian authors themselves constructed, perceived and were influenced by notions of ›empire‹. Biblical scholars like Hraban Maur initiated an authoritative discourse on imperium, which in turn, after the 840s, heavily influenced later authors, perhaps most interestingly Paschasius Radbertus in his Epitaphium Arsenii. While the writings of these authors who looked back at Louis’s reign have often been interpreted as revealing a decline of imperial ideals, they must rather be seen as testifying to a long-lasting concern for a universal Carolingian empire

Eine Tochter gewinnen und verlieren: Corbie und Corvey aus der Sicht von Paschasius Radbertus

Der Vortrag beschäftigt sich mit der Darstellung von Corbie und dem Tochterkloster Corvey in den Werken des Paschasius Radbertus. Als Quellen dienen die Vita Adelhardi und das Epitaphium Arsenii

[Rezension zu:] Jörg W. Busch, Vom Amtswalten bis Königsdienst. Beobachtungen zur ›Staatssprache‹ des Frühmittelalters am Beispiel des Wortes administratio, Hannover (Verlag Hahnsche Buchhandlung) 2007, XXX–156 p. (Monumenta Germaniae Historica. Studien und Texte, 42) ISBN 97-3-7752-5702-2, EUR 20.00.

This study explores the development of the concept of administratio between the early Merovingian period and the late ninth century. The author’s thesis is that administration lost its original connotation of authority delegated by and exercised on behalf of the state, and that this signals the loss of an abstract awareness of the commonwealth in the early medieval period. In the fifth century the idea of administratio as public powers derived from a higher authority was still in place, but soon thereafter this conception vanished (p. 2–3). Yet when in 814 Louis the Pious became emperor, the original meaning of administratio seemed to get a revival – or, should one say, a new lease of life? Hardly, for only in Italy and Aquitaine was there any awareness left of public service as an abstract concept (p. 7–37). North of the Alps, those in charge did not understand such abstract concepts referring to "Staatlichkeit", as is shown by the fact that the authority of the Carolingian mayors of the palace was never called administratio, even though, in the original meaning of the word, the mayoral office was a clear case of delegated power (p. 16–18). ..

Gratitude and loneliness in adults over 40 years: examining the role of psychological flexibility and engaged living

Objectives: The aim of the present study was to investigate the association between trait gratitude and loneliness in a Dutch population sample of adults over 40 years. In addition, the mediating role of psychological flexibility and engaged living between trait gratitude and loneliness was assessed. Method: A total sample of 163 adults of which 65 men (40%) and 98 women (60%) between 41 and 92 years (Mage = 66, SDage = 12) participated in this study. Data from the Loneliness Questionnaire, Flexibility Index Test, Engaged Living Scale and the Short Gratitude, Resentment, and Appreciation Test were used. Mediation analysis was performed.Results: Analysis showed a negative association between trait gratitude and loneliness. In addition, after adjusting for the demographic variables age, gender and educational level, the association between trait gratitude and loneliness was fully mediated by psychological flexibility, and partially mediated by engaged living.Conclusion: This study endorses the importance of trait gratitude and psychological flexibility in relation to experiencing loneliness. Further research is needed to replicate these findings in a more diverse sample and to investigate the causal relationships between these constructs. It would also be interesting to further investigate the role of different age groups and goal (dis)engagement strategies in this relation