A rapid cosmic-ray increase in BC 3372-3371 from ancient buried tree rings in China

Cosmic rays interact with the Earth's atmosphere to produce $^{14}$C, which can be absorbed by trees. Therefore, rapid increases of $^{14}$C in tree rings can be used to probe previous cosmic-ray events. By this method, three $^{14}$C rapidly increasing events have been found. Plausible causes of these events include large solar proton events, supernovae or short gamma-ray bursts. However, due to the lack of measurements of $^{14}$C by year, the occurrence frequency of such $^{14}$C rapidly increasing events is poorly known. In addition, rapid increases may be hidden in the IntCal13 data with five-year resolution. Here we report the result of $^{14}$C measurements using an ancient buried tree during the period between BC 3388 and 3358. We find a rapid increase of about 9\textperthousand~ in the $^{14}$C content from BC 3372 to BC 3371. We suggest that this event could originate from a large solar proton event.Comment: 23 pages, 3 figures, 2 tables, published in Nature Communication

Spectrum of low-lying s3QQˉs^{3}Q\bar{Q} configurations with negative parity

Spectrum of low-lying five-quark configurations with strangeness quantum number $S=-3$ and negative parity is studied in three kinds of constituent quark models, namely the one gluon exchange, Goldstone Boson exchange, and instanton-induced hyperfine interaction models, respectively. Our numerical results show that the lowest energy states in all the three employed models are lying at $\sim$1800 MeV, about 200 MeV lower than predictions of various quenched three-quark models. In addition, it is very interesting that the state with the lowest energy in one gluon exchange model is with spin 3/2, but 1/2 in the other two models.Comment: Version published in Phys. Rev.

Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen

Acknowledgements We would like to acknowledge Richard Paley, Tom Hill and Georgina Rimmer for their collaboration during brown trout infection challenges in CEFAS-Weymouth biosecurity facilities. Bartolomeo Gorgoglione, Stephen W. Feist and Nick G. H. Taylor were supported by a DEFRA grant (F1198).Peer reviewedPostprin

Comment on ``Superconducting PrBa_2Cu_3O_x''

Recently, Zou et al. (Phys. Rev. Lett. 80, 1074, 1998) reported the observation of bulk superconductivity (SC) for a PrBa_2Cu_3O_x (Pr123) single crystal grown by the traveling-solvent floating zone (TSFZ) method. The aim of this Comment is to show the inconsistency of the value of effective magnetic moment \mu_{eff} reported by Zou et al. (2.92\mu_B) with their magnetic susceptibility data. The estimation made directly from their data points gives a considerably smaller value of \mu_{eff}=2.09\mu_B. At the same time the values of mu_{eff}=2.9\mu_B and 3.1\mu_B were obtained for our Pr123 single crystals grown by flux method for H||ab-plane and H||c-axis, respectively. This suggests that Pr occupies only about a half of the RE sites in TSFZ crystal. The other half of the RE sites is occupied most probably by the nonmagnetic Ba. Noteworthy, SC with T_c=43 K was observed earlier for Pr_{0.5}Ca_{0.5}Ba_2Cu_3O_{7-y} thin films. Ba^{2+} has a larger ionic radius than Pr^{3+} and so the substitution of Ba for Pr could give a natural explanation not only for the SC in TSFZ Pr123 but also for the elongation of the distance between the CuO_2 planes observed by Zou et al.Comment: Slightly extended version of Comment accepted to Phys. Rev. Lett. (v.81, N24, 1998), tentatevely to be publ. 14Dec98. 1 page, REVTex; 1 EPS fi

Experimental Quantum Cloning with Prior Partial Information

When prior partial information about a state to be cloned is available, it can be cloned with a fidelity higher than that of universal quantum cloning. We experimentally verify this intriguing relationship between the cloning fidelity and the prior information by reporting the first experimental optimal quantum state-dependent cloning, using nuclear magnetic resonance techniques. Our experiments may further have important implications into many quantum information processing protocols.Comment: 4 pages, 2 figure

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.

The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD). However, the mechanism by which the expression of these innate cytokines is regulated remains unclear. Intelectin (ITLN) is expressed in airway epithelial cells and promotes allergic airway inflammation. We hypothesized that ITLN is required for allergen-induced IL-25, IL-33, and TSLP expression. In two asthma models, Itln knockdown reduced allergen-induced increases in Il-25, Il-33, and Tslp and development of type 2 response, eosinophilic inflammation, mucus overproduction, and airway hyperresponsiveness. Itln knockdown also inhibited house dust mite (HDM)-induced early upregulation of Il-25, Il-33, and Tslp in a model solely inducing airway sensitization. Using human airway epithelial cells, we demonstrated that HDM-induced increases in ITLN led to phosphorylation of epidermal growth factor receptor and extracellular-signal regulated kinase, which were required for induction of IL-25, IL-33, and TSLP expression. In two AD models, Itln knockdown suppressed expression of Il-33, Tslp, and Th2 cytokines and eosinophilic inflammation. In humans, ITLN1 expression was significantly increased in asthmatic airways and in lesional skin of AD. We conclude that ITLN contributes to allergen-induced Il-25, Il-33, and Tslp expression in asthma and AD

Expression, purification and kinase activity analysis of maize ZmSPK1, a member of plant SnRK2 subfamily

Kinase activity is essential for a protein kinase to perform its biological function. In previous study we have cloned a novel plant SnRK2 subfamily gene from maize and named it as ZmSPK1. In this study thecDNA of ZmSPK1 with dHA-His6 tag was amplified by PCR and was subcloned into the yeast expression vector p426GAL1. The constructed plasmid named as p426GAL1-SPK1-dHA-His6 was transformed into Saccharomyces cerevisiae. Under the induction of galactose the recombinant protein was expressed. The purified recombinant protein showed a single specific band by the analysis of the western-blot. In an in vitro kinase assay, the purified recombinant protein showed phosphorylation and autophosphorylation activity. This showed that ZmSPK1 encodes a functional protein kinase