206 research outputs found
Ambulatory blood pressure monitoring and renal functions in children with a solitary kidney
The aim of this study is to investigate the blood pressure (BP) profile, microalbuminuria, renal functions, and relations with remaining normal kidney size in children with unilateral functioning solitary kidney (UFSK). Sixty-six children with UFSK were equally divided into three groups: unilateral renal agenesis (URA), unilateral atrophic kidney (UAK), and unilateral nephrectomy (UNP). Twenty-two age-, weight-, and height-matched healthy children were considered as a control group. The serum creatinine level and first-morning urine microalbumin and creatinine concentrations were determined by the standard methods. Also, the BP profile was determined by ambulatory blood pressure monitoring (ABPM). We found that the serum creatinine level was higher and creatinine clearance was lower in each patient groups compared to those of the control group (p < 0.05). Compared with the controls, each group of patients had mean office, 24-h, daytime, and night-time systolic and diastolic BP values similar to those of the controls (p > 0.05). An inverse correlation was found between the renal size standard deviation scores (SDS) of normal kidneys and 24-h systolic and diastolic BP load SDS in all of the patients (p < 0.05; r = −0.372, r = −0.295, respectively). The observed relationship between renal size SDS and 24-h mean arterial pressure (MAP), systolic and diastolic BP load SDS suggests that children with UFSK should be evaluated by using ABPM for the risk of hypertension
Living instruments and theoretical terms : Xenografts as measurements in cancer research
I discuss the relationship between theoretical terms and measuring devices using a very peculiar example from biomedical research: cancer transplantation models. I do so through two complementary comparisons. I first show how a historical case study can shed light on a similar case from contemporary biomedical research. But I also compare both to a paradigmatic case of measurement in the physical sciences -- thermometry -- which reveals some of the most relevant epistemological issues. The comparison offers arguments for the recent debate on the operational definition of Cancer Stem Cells, and thereby suggests the relevance of a comparative approach in the history and philosophy of science
148. Sex differences in the levels of unconjugated testosterone in amniolic fluid and maternal plasma during early pregnancy
Testosterone levels in fetal testes and adrenals during the second trimester of pregnancy
Endocrine Allergy. Clinical Reactions of Allergy to Endogenous Hormones and their Treatment*
Amniotic fluid follicle-stimulating hormone and fetal sex determination in the second trimester of pregnancy
Über das vegetative Nervensystem und seine Beeinflussung durch pharmakologische Gifte bei Katatonikern
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