9 research outputs found

    Why Do People Work if They Are Not Paid? An Example from Eastern Europe

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    The phenomenon of non-paid work on a massive scale is discussed. Research is done in a textile firm in Eastern Europe, which withheld payment for the performed work for more than a half a year. The following questions were studied: (a) what are the perceptions of work and work results in this highly unusual situation, (b) what kind of other incentives are available to substitute for lack of payment, (c) how do people explain their behavior under such circumstances. Results show that lack of payment is not a barrier for a high level of effort spent in work, relatively good performance, and organizational commitment. The reasons lye mainly in a high level of need for sense, i.e. tendency to search for the meaning of one's actions and the meaning of life, as well as in perceptions of the work situation as opportunities to satisfy higher order (Maslow type of) needs (self-actualization, esteem from others, and belongingness).http://deepblue.lib.umich.edu/bitstream/2027.42/39593/3/wp206.pd

    Why Do People Work if They Are Not Paid? An Example from Eastern Europe

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    The phenomenon of non-paid work on a massive scale is discussed. Research is done in a textile firm in Eastern Europe, which withheld payment for the performed work for more than a half a year. The following questions were studied: (a) what are the perceptions of work and work results in this highly unusual situation, (b) what kind of other incentives are available to substitute for lack of payment, (c) how do people explain their behavior under such circumstances. Results show that lack of payment is not a barrier for a high level of effort spent in work, relatively good performance, and organizational commitment. The reasons lye mainly in a high level of need for sense, i.e. tendency to search for the meaning of one's actions and the meaning of life, as well as in perceptions of the work situation as opportunities to satisfy higher order (Maslow type of) needs (self-actualization, esteem from others, and belongingness).

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    Identification of HI-Like Loop in CELO Adenovirus Fiber for Incorporation of Receptor Binding Motifs▿

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    Vectors based on the chicken embryo lethal orphan (CELO) avian adenovirus (Ad) have two attractive properties for gene transfer applications: resistance to preformed immune responses to human Ads and the ability to grow in chicken embryos, allowing low-cost production of recombinant viruses. However, a major limitation of this technology is that CELO vectors demonstrate decreased efficiency of gene transfer into cells expressing low levels of the coxsackie-Ad receptor (CAR). In order to improve the efficacy of gene transfer into CAR-deficient cells, we modified viral tropism via genetic alteration of the CELO fiber 1 protein. The αv integrin-binding motif (RGD) was incorporated at two different sites of the fiber 1 knob domain, within an HI-like loop that we identified and at the C terminus. Recombinant fiber-modified CELO viruses were constructed containing secreted alkaline phosphatase (SEAP) and enhanced green fluorescent protein genes as reporter genes. Our data show that insertion of the RGD motif within the HI-like loop of the fiber resulted in significant enhancement of gene transfer into CAR-negative and CAR-deficient cells. In contrast, CELO vectors containing the RGD motif at the fiber 1 C terminus showed reduced transduction of all cell lines. CELO viruses modified with RGD at the HI-like loop transduced the SEAP reporter gene into rabbit mammary gland cells in vivo with an efficiency significantly greater than that of unmodified CELO vector and similar to that of Ad type 5 vector. These results illustrate the potential for efficient CELO-mediated gene transfer into a broad range of cell types through modification of the identified HI-like loop of the fiber 1 protein

    Microeconomic Aspects of Economic Growth in Eastern Europe and the Former Soviet Union, 1950-2000

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