636 research outputs found
AKEM: Aligning Knowledge Base to Queries with Ensemble Model for Entity Recognition and Linking
This paper presents a novel approach to address the Entity Recognition and
Linking Challenge at NLPCC 2015. The task involves extracting named entity
mentions from short search queries and linking them to entities within a
reference Chinese knowledge base. To tackle this problem, we first expand the
existing knowledge base and utilize external knowledge to identify candidate
entities, thereby improving the recall rate. Next, we extract features from the
candidate entities and utilize Support Vector Regression and Multiple Additive
Regression Tree as scoring functions to filter the results. Additionally, we
apply rules to further refine the results and enhance precision. Our method is
computationally efficient and achieves an F1 score of 0.535
The neutrophil-lymphocyte ratio to predict poor prognosis of critical acute myocardial infarction patients: a retrospective cohort study
IntroductionInflammation is closely related to adverse outcomes of acute myocardial infarction (AMI). This study aimed to evaluate whether neutrophil-lymphocyte ratio (NLR) can predict poor prognosis of critical AMI patients.
Materials and methodsWe designed a retrospective cohort study and extracted AMI patients from the “Medical Information Mart for Intensive Care-III” database. The primary outcome was 1-year all-cause mortality. The secondary outcomes were 90-day and in-hospital all-cause mortalities, and acute kidney injury (AKI) incidence. The optimal cut-offs of NLR were picked by X-tile software according to the 1-year mortality and patient groups were created: low-NLR ( 21.1). Cox and modified Poisson regression models were used to evaluate the effect of NLR on outcomes in critically AMI patients.
ResultsFinally, 782 critical AMI patients were enrolled in this study, and the 1-year mortality was 32% (249/782). The high- and very high-NLR groups had a higher incidence of outcomes than the low-NLR group (P < 0.05). The multivariate regression analyses found that the high- and very high-NLR groups had a higher risk of 1-year mortality (Hazard ratio (HR) = 1.59, 95% CI: 1.12 to 2.24, P = 0.009 and HR = 1.73, 95% CI: 1.09 to 2.73, P = 0.020), 90-day mortality (HR = 1.69, 95% CI: 1.13 to 2.54, P = 0.011 and HR = 1.90, 95% CI: 1.13 to 3.20, P = 0.016), in-hospital mortality (Relative risk (RR) = 1.77, 95% CI: 1.14 to 2.74, P = 0.010 and RR = 2.10, 95% CI: 1.23 to 3.58, P = 0.007), and AKI incidence (RR = 1.44, 95% CI: 1.06 to 1.95, P = 0.018 and RR = 1.34, 95% CI: 0.87 to 2.07, P = 0.180) compared with low-NLR group. NLR retained stable predictive ability in sensitivity analyses.
ConclusionBaseline NLR is an independent risk factor for 1-year mortality, 90-day mortality, in-hospital mortality, and AKI incidence in AMI patients
Electric-field induced droplet vertical vibration and horizontal motion: Experiments and simulations
In this work, Electrowetting on Dielectric (EWOD) and electrostatic induction
(ESI) are employed to manipulate droplet on the PDMS-ITO substrate. Firstly, we
report large vertical vibrations of the droplet, induced by EWOD, within a
voltage range of 40 to 260 V. The droplet's transition from a vibrating state
to a static equilibrium state are investigated in detail. It is indicated that
the contact angle changes synchronously with voltage during the vibration. The
electric signal in the circuit is measured to analyze the vibration state that
varies with time. By studying the influence of driving voltage on the contact
angle and the amplitude in the vibration, it is shown that the saturation
voltage of both contact angle and amplitude is about 120 V. The intrinsic
connection between contact angle saturation and amplitude saturation is
clarified by studying the surface energy of the droplet. A theoretical model is
constructed to numerically simulate the vibration morphology and amplitude of
the droplet. Secondly, we realize the horizontal motion of droplets by ESI at
the voltage less than 1000 V. The charge and electric force on the droplet are
numerically calculated. The frictional resistance coefficients of the droplet
are determined by the deceleration of the droplet. Under consideration of
frictional resistance of the substrate and viscous resistance of the liquid,
the motion of the droplet is calculated at 400 V and 1000 V, respectively. This
work introduces a new method for manipulating various forms of droplet motion
using the single apparatus
Second harmonic optical coherence tomography
Second harmonic optical coherence tomography, which uses coherence gating of
second-order nonlinear optical response of biological tissues for imaging, is
described and demonstrated. Femtosecond laser pulses were used to excite second
harmonic waves from collagen harvested from rat tail tendon and a reference
nonlinear crystal. Second harmonic interference fringe signals were detected
and used for image construction. Because of the strong dependence of second
harmonic generation on molecular and tissue structures, this technique offers
contrast and resolution enhancement to conventional optical coherence
tomography.Comment: 3 pages, 5 figures. Submitted on November 8, 2003, this paper has
recently been accepted by Optics Letter
Manufacture of IRDye800CW-coupled Fe3O4 nanoparticles and their applications in cell labeling and in vivo imaging
BackgroundIn recent years, near-infrared fluorescence (NIRF)-labeled iron nanoparticles have been synthesized and applied in a number of applications, including the labeling of human cells for monitoring the engraftment process, imaging tumors, sensoring the in vivo molecular environment surrounding nanoparticles and tracing their in vivo biodistribution. These studies demonstrate that NIRF-labeled iron nanoparticles provide an efficient probe for cell labeling. Furthermore, the in vivo imaging studies show excellent performance of the NIR fluorophores. However, there is a limited selection of NIRF-labeled iron nanoparticles with an optimal wavelength for imaging around 800 nm, where tissue autofluorescence is minimal. Therefore, it is necessary to develop additional alternative NIRF-labeled iron nanoparticles for application in this area.ResultsThis study manufactured 12-nm DMSA-coated Fe3O4 nanoparticles labeled with a near-infrared fluorophore, IRDye800CW (excitation/emission, 774/789 nm), to investigate their applicability in cell labeling and in vivo imaging. The mouse macrophage RAW264.7 was labeled with IRDye800CW-labeled Fe3O4 nanoparticles at concentrations of 20, 30, 40, 50, 60, 80 and 100 μg/ml for 24 h. The results revealed that the cells were efficiently labeled by the nanoparticles, without any significant effect on cell viability. The nanoparticles were injected into the mouse via the tail vein, at dosages of 2 or 5 mg/kg body weight, and the mouse was discontinuously imaged for 24 h. The results demonstrated that the nanoparticles gradually accumulated in liver and kidney regions following injection, reaching maximum concentrations at 6 h post-injection, following which they were gradually removed from these regions. After tracing the nanoparticles throughout the body it was revealed that they mainly distributed in three organs, the liver, spleen and kidney. Real-time live-body imaging effectively reported the dynamic process of the biodistribution and clearance of the nanoparticles in vivo.ConclusionIRDye800CW-labeled Fe3O4 nanoparticles provide an effective probe for cell-labeling and in vivo imaging
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Miniaturized Head-Mount Doppler Optical Coherence Tomography Scope for Freely Moving Mouse.
This study presents a miniaturized head-mount optical coherence tomography (OCT) system tailored for high-resolution brain imaging in freely moving mice, providing an advanced noninvasive imaging tool in neuroscience research. Leveraging optical coherence tomography technology, the system enables depth-resolved imaging and integrates functional OCT extensions, including angiography and Doppler imaging. Remarkably lightweight at 1.5 g, the device allows for the preservation of natural mouse behavior during imaging sessions. With a maximum 4 × 4 mm field of view and 7.4 μm axial resolution, the system offers reliable imaging capabilities. Noteworthy features include focal adjustability, rotary joint integration for fiber-twist-free operation, and a high-speed swept-source OCT laser at 200 kHz, facilitating real-time imaging. By providing insights into brain mechanisms and neurological disorders without disrupting natural behavior, this innovative system holds promise as a powerful tool in neuroscience research. Its compact design and comprehensive imaging capabilities make it well-suited for studying various brain regions and dynamic processes, contributing significantly to our understanding of brain function and pathology
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