Palladium-Catalyzed C–H Trifluoroethoxylation of <i>N</i>‑Sulfonylbenzamides

The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C–H trifluoroethoxylation has not been reported to date. A protocol of Pd­(II)-catalyzed <i>o</i>-C–H trifluoroethoxylation of a broad range of benzoic acid derivatives (i.e., <i>N</i>-sulfonylbenzamides) has been developed. This method is also applied to the formal synthesis of the drug molecule flecainide, wherein the first <i>m</i>-C–H trifluoroethoxylation is also exemplified

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mtDNA Haplotype Sequence Alignment

Swamp type and river type haplotype alignments. These data were used to generate Fig.S1

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