Principles of pharmacological correction of pulmonary arterial hypertension

Prostanoids are a promising group of drugs for the treatment of pulmonary arterial hypertension (PAH), since they possess not only vasodilating, but also antiplatelet and antiproliferative actions. Therefore, it seems logical to use prostacyclin and its analogs to treat patients with various forms of PA

Nutritional correction of cognitive impairment in patients with signs of premature aging

This paper deals with the questions of cognitive impairment in patients with signs of premature aging. Within the framework of this paper, it is shown that patients with a "negative" variant of the biological age have lower cognitive abilities than those with a "positive" variant of biological age. It is determined that nutritional support in patients with a "negative" variant of biological age ensures almost the same scores in the evaluation of cognitive functions, as in patients with a "positive" version of biological ag

The definition of specific antiparkinsonian effects of Rapitalam

Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor

The prevalence and phenotypic characteristics of the syndrome of premature aging in women in peri- and post-menopausal period

This paper presents the results of our own study of the prevalence and phenotypic characteristics of the syndrome of premature aging in women in peri- and post-menopausal period. It presents data on that against the background of menopausal changes since the age of 50 years, premature aging syndrome develops in women, which manifests itself in accelerated aging by 1.3–1.6 time

Meteoprotective properties of melaxen in old and middle aged patients with ischemic heart disease in combination with arterial hypertension

We studied 102 patients (mean age 60.1±3.3 years) with arterial hypertension (AH) II-III stage, grade 2-3 and ischemic heart disease (exertional angina functional class (FC) I-II, postinfarction cardiosclerosis). The control group of patients received traditional therapy (TT): beta -blockers, calcium channel blockers, ACE inhibitors, antiplatelet agents, diuretics and nitrate

Genetic factors of decreased kidney function in patients with chronic glomerulonephritis

The article presents the results of studying the interaction of polymorphic variants of vascular homeostasis genes (I/D ACE, 4а/4b eNOS, S311C PON2, (-6) A/G AGT, (-1166) A/С AGTR1, G/A GNB3 (rs.2301339), G460W ADD1, (+46) G/A ADRB2, K198N EDN1, (+6986) G/A CYP3A5) with the state of renal function at the onset of chronic glomerulonephriti

Clinical and genetic research of chronic glomerulonephritis

The paper presents data on interaction of candidate genes (S311C PON2, (-6)A/G AGT, (-1166)A/CAGTR1, (-592)C/A IL-10, VNTR IL-1Ra, T113M IL-9, K198N EDN1, (+46)G/A ADRB2, G/A GNB3 (rs.2301339)) with oligogenic and continuous characters of chronic glomerulonephriti

The risks of developing adverse outcomes according to geriatric status in patients with coronary heart disease with plannedaorto-coronary artery bypass grafting

The article assesses the risks of developing adverse outcomes in patients with coronary heart disease who underwent planned aorto-coronary artery bypass grafting according to geriatric status using such scales as the cardiovascular health study frailt

Studying the Impact of the genetic polymorphisms of chemokines on the arterial pressure level and kidney function in patient with the chronic glomerulonephritis

It has been established that the genetic marker А I-TAC (rs 4512021) is the risk factor for genesis of the severe arterial hypertension at the chronic glomerulonephritis (OR=1,65) and the genotypes АА and AG I-TAC are the risk factors of depression of the kidney functio

Analysis of the influence of chronic heart failure type on changes in the microelement composition of myocardial tissue in patients of senile age

Aim: conduct a comparative analysis of the content and distribution of macroelements (Ca2+, K+, Mg2+, and Na+) in myocardial tissue according to autopsy data in elder patients with CHF, depending on the LV E