DIAGNOSTIC AND THERAPEUTIC PROBLEMS OF ACUTE RENAL FAILURE IN CHILDHOOD

Acute renal failure (ACR) is a clinical-biological syndrome of sudden rapidly advancing, commonly reversible damage of renal function when a normal body homeostasis cannot be maintained. In the Department of Paediatrics, Medical University of Varna, 18 children with ACR were treated. The most common reasons for the ACR were the following: acute glomerulonephritis, haemolytic-uraemic syndrome, and severe malformations of the urinary tract. Blood urea, creatinine, ionogram,acid-base balance, and diuresis were dynamically monitored in all the children. Therapeutic behaviour was directed towards the correction of the dyselectrolytaemia and acid-alkaline profile. The elevated lethality rate still persisted. Three patients deceased

Возможности рекультивации каменных отвалов пустых пород после извлечения медной руды

The Elatsite porphyry copper deposit is formed spatially and genetically in magmatic intrusive and effusive rocks of the 1200-1500 m above sea level (asl). At the places where there are more remnants of sulphide minerals, are highly acidic and pollute adjacent waterways. In this paper we present some of the research on the properties of bulk materials suitable for coating the root layer for biological reclamation.Овал порфиритовой меди Элатсайт сформирован из магматических интрузивных и эффузивных пород на высоте 1200-1500 м над уровнем моря. На местах, где много остатков сульфидных минералов, высока кислотность и высоко загрязнение подземных вод. В этой работе представлены результаты исследований по изучению свойств материалов, подходящих для создания покрывающего корнеобитаемого слоя для биологической рекультивации

Hallmarks of mechanochemistry: From nanoparticles to technology

The aim of this review article on recent developments of mechanochemistry (nowadays established as a part of chemistry) is to provide a comprehensive overview of advances achieved in the field of atomistic processes, phase transformations, simple and multicomponent nanosystems and peculiarities of mechanochemical reactions. Industrial aspects with successful penetration into fields like materials engineering, heterogeneous catalysis and extractive metallurgy are also reviewed. The hallmarks of mechanochemistry include influencing reactivity of solids by the presence of solid-state defects, interphases and relaxation phenomena, enabling processes to take place under non-equilibrium conditions, creating a well-crystallized core of nanoparticles with disordered near-surface shell regions and performing simple dry time-convenient one-step syntheses. Underlying these hallmarks are technological consequences like preparing new nanomaterials with the desired properties or producing these materials in a reproducible way with high yield and under simple and easy operating conditions. The last but not least hallmark is enabling work under environmentally friendly and essentially waste-free conditions (822 references).Slovak Grant Agency VEGA 2/0009/11, 2/0043/11Slovak Agency for Science and Development APVV VV-0189-10, VV-0528-11Russian Foundation for Basic Research 10-03-00942a, 12-03-00651aMinistry of Science and Higher education in Poland CUT/c-1/DS/KWC/2008-2012, PB1T09B02330, NN209145136, NN20914893

Fostering the Development and Implementation of Digital Learning Strategies for Digitization in Schools

In today's fast-paced and rapidly changing world, teachers must continually update their skills and competencies to meet the new requirements of education. As new technologies and teaching methodologies emerge, teachers need to stay abreast of these changes to be effective in the classroom.The paper discusses an approach for improvement of skills and competencies of the adult educators across Europe on how to use digital tools, digital content libraries and technology-enhanced methods, among them the “Episodes of Situated Learning”, to ensure engaging and meaningful virtual instruction in inclusive settings

Complete Experimental Structure Determination of the p(3x2)pg Phase of Glycine on Cu{110}

We present a quantitative low energy electron diffraction (LEED) surface-crystallograpic study of the complete adsorption geometry of glycine adsorbed on Cu{110} in the ordered p(3×2) phase. The glycine molecules form bonds to the surface through the N atoms of the amino group and the two O atoms of the de-protonated carboxylate group, each with separate Cu atoms such that every Cu atom in the first layer is involved in a bond. Laterally, N atoms are nearest to the atop site (displacement 0.41 Å). The O atoms are asymmetrically displaced from the atop site by 0.54 Å and 1.18 Å with two very different O-Cu bond lengths of 1.93 Å and 2.18 Å. The atom positions of the upper-most Cu layers show small relaxations within 0.07 Å of the bulk-truncated surface geometry. The unit cell of the adsorbate layer consists of two glycine molecules, which are related by a glide-line symmetry operation. This study clearly shows that a significant coverage of adsorbate structures without this glide-line symmetry must be rejected, both on the grounds of the energy dependence of the spot intensities (LEED-IV curves) and of systematic absences in the LEED pattern

Linking world bank development indicators and outcomes of congenital heart surgery in low-income and middle-income countries: Retrospective analysis of quality improvement data

Objective Many low-income and middle-income countries (LMICs) struggle to provide the health services investment required for life-saving congenital heart disease (CHD) surgery. We explored associations between risk-adjusted CHD surgical mortality from 17 LMICs and global development indices to identify patterns that might inform investment strategies. Design Retrospective analysis: country-specific standardised mortality ratios were graphed against global development indices reflective of wealth and healthcare investment. Spearman correlation coefficients were calculated. Setting and participants The International Quality Improvement Collaborative (IQIC) keeps a volunteer registry of outcomes of CHD surgery programmes in low-resource settings. Inclusion in the IQIC is voluntary enrolment by hospital sites. Patients in the registry underwent congenital heart surgery. Sites that actively participated in IQIC in 2013, 2014 or 2015 and passed a 10% data audit were asked for permission to share data for this study. 31 sites in 17 countries are included. Outcome measures In-hospital mortality: standardised mortality ratios were calculated. Risk adjustment for in-hospital mortality uses the Risk Adjustment for Congenital Heart Surgery method, a model including surgical risk category, age group, prematurity, presence of a major non-cardiac structural anomaly and multiple congenital heart procedures during admission. Results The IQIC registry includes 24 917 congenital heart surgeries performed in children less than 18 years of age. The overall in-hospital mortality rate was 5.0%. Country-level congenital heart surgery standardised mortality ratios were negatively correlated with gross domestic product (GDP) per capita (r=-0.34, p=0.18), and health expenditure per capita (r=-0.23, p=0.37) and positively correlated with under-five mortality (r=0.60, p=0.01) and undernourishment (r=0.39, p=0.17). Countries with lower development had wider variation in mortality. GDP per capita is a driver of the association between some other measures and mortality. Conclusions Results display a moderate relationship among wealth, healthcare investment and malnutrition, with significant variation, including superior results in many countries with low GDP per capita. These findings provide context and optimism for investment in CHD procedures in low-resource settings. © 2019 BMJ Publishing Group Limited

WhiteHaul: An Efficient Spectrum Aggregation System for Low-Cost and High Capacity Backhaul over White Spaces

We address the challenge of backhaul connectivity for rural and developing regions, which is essential for universal fixed/mobile Internet access. To this end, we propose to exploit the TV white space (TVWS) spectrum for its attractive properties: low cost, abundance in under-served regions and favorable propagation characteristics. Specifically, we propose a system called WhiteHaul for the efficient aggregation of the TVWS spectrum tailored for the backhaul use case. At the core of WhiteHaul are two key innovations: (i) a TVWS conversion substrate that can efficiently handle multiple non-contiguous chunks of TVWS spectrum using multiple low cost 802.11n/ac cards but with a single antenna; (ii) novel use of MPTCP as a link-level tunnel abstraction and its use for efficiently aggregating multiple chunks of the TVWS spectrum via a novel uncoupled, cross-layer congestion control algorithm. Through extensive evaluations using a prototype implementation of WhiteHaul, we show that: (a) WhiteHaul can aggregate almost the whole of TV band with 3 interfaces and achieve nearly 600Mbps TCP throughput; (b) the WhiteHaul MPTCP congestion control algorithm provides an order of magnitude improvement over state of the art algorithms for typical TVWS backhaul links. We also present additional measurement and simulation based results to evaluate other aspects of the WhiteHaul design

One-step isolation and biochemical characterization of a highlyactive plant PSII monomeric core

We describe a one-step detergent solubilization protocol for isolating a highly active form of Photosystem II (PSII) from Pisum sativum L. Detailed characterization of the preparation showed that the complex was a monomer having no light harvesting proteins attached. This core reaction centre complex had, however, a range of low molecular mass intrinsic proteins as well as the chlorophyll binding proteins CP43 and CP47 and the reaction centre proteins D1 and D2. Of particular note was the presence of a stoichiometric level of PsbW, a low molecular weight protein not present in PSII of cyanobacteria. Despite the high oxygen evolution rate, the core complex did not retain the PsbQ extrinsic protein although there was close to a full complement of PsbO and PsbR and partial level of PsbP. However, reconstitution of PsbP and PsbPQ was possible. The presence of PsbP in absence of LHCII and other chlorophyll a/b binding proteins confirms that LHCII proteins are not a strict requirement for the assembly of this extrinsic polypeptide to the PSII core in contrast with the conclusion of Caffarri et al. (2009)

Link prediction in online social networks using group information

Users of online social networks voluntarily participate in different user groups or communities. Researches suggest the presence of strong local community structure in these social networks, i.e., users tend to meet other people via mutual friendship. Recently, different approaches have considered communities structure information for increasing the link prediction accuracy. Nevertheless, these approaches consider that users belong to just one community. In this paper, we propose three measures for the link prediction task which take into account all different communities that users belong to. We perform experiments for both unsupervised and supervised link prediction strategies. The evaluation method considers the links imbalance problem. Results show that our proposals outperform state-of-the-art unsupervised link prediction measures and help to improve the link prediction task approached as a supervised strategy.São Paulo Research Foundation (FAPESP) (grants 2011/22749-8 and 2013/12191-5)National Council for Scientific and Technological Development (CNPq) (grant 151836/2013-2)14th International Conference on Computational Science and its Applications (ICCSA).\ud Guimarães, Portugal. 30 June - 3 July 2014