Leben und Zusammenleben der Sprachgruppen in Südtirol: Auswirkungen von Autonomie und Minderheitenschutz auf Schule und Bevölkerung

Effect of TP on Biochemical Indicators. (DOCX 14 kb

DataSheet1_Understanding trade-offs and synergies among soil functions to support decision-making for sustainable cultivated land use.xls

Soil provides a diverse and complex range of ecosystem services. Understanding the trade-offs and synergies among soil functions is foundational for effective soil ecosystem management and human well-being. In contrast, the long-term pursuit of solely productive functions in cultivated land use has resulted in soil degradation and weakened other ecological functions. This study collected soil, topographic landform, climate, and management data from 151 fields in four counties and three climatic zones in China. The Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model was used to evaluate nutrient retention, water production, and carbon storage, and the market value method was used to evaluate the value of the soil production function. A semi-quantitative model of Bayesian belief networks (BBNs) was used to simulate soil processes, thus revealing factors potentially influencing the supply capacity of five soil functions. Sensitivity analysis was used to identify the key variables influencing soil functional supply, and the probabilistic inference was used to identify interactions among soil’s multiple functions. The main findings were as follows: 1) In four counties, the spatial heterogeneity in the supply of the five soil functions was relatively high. 2) The primary variables influencing the supply of soil’s multiple functions were climatic conditions, management level, carbon storage, soil nutrients, soil biology, soil structure, and topography. 3) Trade-offs existed among primary productivity (PP), water purification and regulation (WPR), and carbon sequestration and regulation (CSR). Moreover, the provision of functional and intrinsic biodiversity (PFIB), WPR, and CSR were synergistic; specifically, the CSR and WPR services synergized with the nutrient provision and cycling (PCN). This research may aid in understanding the supply of, and interactions among soil’s multiple functions, thus aiding in using BBNs to analyze soil ecosystem services. In addition, this study may provide a reference for management decision-making to maximize the overall benefits of soil functions in cultivated land use.</p

Transforming Thermally Activated Delayed Fluorescence to Room-Temperature Phosphorescence through Modulation of the Donor in Charge-Transfer Cocrystals

A cocrystallization strategy is used through incorporation of 1,2,4,5-tetracyanobenzene (TCNB) as an acceptor with halogen-substituent thioxanthone (TX) derivatives as donors. The resulting cocrystals TT-R (R = H, F, Cl, Br, or I) transform the thermally activated delayed fluorescence emission in the TT-H, TT-F, and TT-Cl cocrystals to room-temperature phosphorescence in the TT-Br and TT-I cocrystals. Definite crystal packing structures demonstrate a 1:1 alternative donor–acceptor stacking in the TT-H cocrystal, a 2:1 alternative donor–acceptor stacking in the TT-F and TT-Cl cocrystals, and a separate stacking of donor and acceptor in the TT-Br and TT-I cocrystals. A transformation law can be revealed that with an increase in atomic number from H, F, Cl, Br, to I, the cocrystals show the structural transformation of the number of aggregated TX-R molecules from monomers to dimers and finally to multimers. This work will facilitate an understanding of the effect of halogen substituents on the crystal packing structure and luminescence properties in the cocrystals

MOESM1 of Knockout of interleukin-17A protects against sepsis-associated acute kidney injury

Additional file 1. The grouping of experimental animals

Foi et vie : revue de quinzaine, religieuse, morale, littéraire, sociale

01 février 19071907/02/01 (A10,N3)-1907/02/01

Additional file 2: Table S2. of Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes

Effects of TP on the CYP450s enzyme substrates and metabolites. (DOCX 16 kb

Investigation of the Effect of Grinding Parameters on Surface Quality in Grinding of TC4 Titanium Alloy

In order to improve the surface quality of TC4 titanium alloy parts, the effect of grinding parameters on surface integrity must be known. In this research, an experimental analysis has been conducted to understand the effect of grinding parameters, including cutting velocity, feed rate, grinding depth and abrasive size, on material removal and surface integrity. Before conducting experiment, test samples were pre-cut using same cutting parameters as in actual blade processing. Five level single factor experiments were designed for each grinding parameter, and surface parameters were measured. The results reveal that surface parameters are affected significantly by the grinding parameters

Data_Sheet_1_Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults.docx

BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between them. Therefore, this study focused on the association between arterial stiffness and HGS in relatively healthy older adults in Beijing, China.MethodsIn 2016, 2,217 adult volunteers were recruited in Beijing. Brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index were measured using an automatic vascular profiling system. Carotid artery intima-media thickness and common carotid artery-internal diameter (CCAID) were evaluated using Doppler ultrasound, and HGS was measured with a dynamometer. Low HGS was determined using the Asian Sarcopenia Working Group 2019 criteria. Multivariate linear and logistic regressions evaluated the relationship between arterial stiffness and HGS.ResultsUltimately, 776 relatively healthy older adults (mean age 69.05 ± 6.46 years) were included. Based on the AWGS2019 criteria, 137 participants were defined as having low HGS. Compared to the normal HGS group, the low HGS group was older and had higher baPWV (p ConclusionArterial stiffness and HGS were significantly negatively correlated in relatively healthy Chinese older adults. Low HGS is associated with increased arterial stiffness. Encouraging exercise training to improve HGS, thereby reducing arterial stiffness and the risk of cardiovascular events, may be a simple and effective intervention.</p

Podocyte injury and activation of the mTOR-ULK1 pathway.

<p>(A-B).Western blot analysis of cellular proteins confirmed that the most significant upregulated expression of mTOR signaling pathway-associated proteins was observed in 2 h puromycin amino nucleotide (PAN)-treated differentiated mouse podocyte cells (MPCs) compared to that in the control group and the other time points of treated cells, demonstrating the obvious activation of the mTOR-ULK pathway, *<i>P</i><0.05 vs Control. (C, D, F).At this same time point, the expression of synaptopodin decreased and the filamentous expression (red fluorescence) was barely visible; therefore, we selected 2 h as the modeling time. PAN-treated podocytes showed an increase in ULK1 phosphorylation, a decrease in LC3 II expression, and a decrease in cellular GFP-LC3 granular expression (green fluorescence), indicating the inhibition of autophagy.(E).Compared to GFP-LC3 transfected cells, there was no granulation in GFP transfected cells. Magnification  = ×1200.</p

Aggravation of podocyte injury upon autophagy inhibition.

<p>(A–B).The Western blot results confirmed that the expression of synaptopodin and LC3 II was lower in ATG7 (a key protein of autophagy) RNAi-mediated knock down differentiated MPCs (siRNA+R+P) than in the siRNA negative control group (siCon+R+P). Both groups were pretreated with rapamycin and treated with PAN,*<i>P</i><0.05 vs Control, ^#<i>P</i><0.05 vs siCon+R+P. (C).In the presence of siRNA interference, GFP-LC3 granular expression (green fluorescence) nearly disappeared and cells appeared unhealthy with long and narrow nuclei. Synaptopodin expression (red fluorescence) was significantly downregulated. Magnification  = ×1200.</p