On mixed abstraction, languages and simulation approach to refinement with SystemC AMS

Executable specifications and simulations arecornerstone to system design flows. Complex mixed signalembedded systems can be specified with SystemC AMSwhich supports abstraction and extensible models of computation. The language contains semantics for moduleconnections and synchronization required in analog anddigital interaction. Through the synchronization layer, user defined models of computation, solvers and simulators can be unified in the SystemC AMS simulator for achieving low level abstraction and model refinement. These improvements assist in amplifying model aspects and their contribution to the overall system behavior. This work presents cosimulating refined models with timed data flow paradigm of SystemC AMS. The methodology uses Cbased interaction between simulators. An RTL model ofdata encryption standard is demonstrated as an example.The methodology is flexible and can be applied in earlydesign decision trade off, architecture experimentation and particularly for model refinement and critical behavior analysis

Functional/thermal verification and validation of an S-band radio for the nanosatellites

© 2018 COSPAR An S-band radio designed with commercial-grade components for the nanosatellites is functionally and thermally characterized for quiet transmission. The QPSK modulation impairments are minor over −20 °C to +50 °C at 24, 26, 28 and 30 dBm RF levels. The channel response is linear in error vector magnitude, frequency, phase, amplitude and IQ errors. On the average, the stability of amplifier bias and nonlinearity gives −22 dBc maximum upper/lower adjacent channel power and 1.27 MHz occupied channel bandwidth. The acceptable level test results provide good confidence toward robust space-to-earth transmission in variable solar weather at low earth orbital altitudes

Validation of the safety requirements of the landing gear using fault tree analysis

We analyze the functionality of the landing system of a regional aircraft in the extension and cruise flight modes and validate safety requirements through the fault tree analysis. The main landing gear system is captured in the electromechanical–fluidic domain and system behavior is abstracted in an elementary hydraulic circuit. The functional representation is then constructed into a fault tree which allows analysis of the failure propagation originating at different branch terminals, for instance, at the main landing gear actuator which extends the gear and holds it retracted during the cruise, door actuator, door uplocks, and hydraulic power supply. Each component is assigned a failure probability. Each failure mode is abstracted as a top-level event having a probability of failure and through Boolean combinations of component failures in the lower branches. Two reliability aspects considered are the availability to fully lower the landing gear and the integrity of inadvertent gear or door extension while cruising. Architectural changes through undercarriage system reconfiguration and component redundancy have been exploited to improve system failure rates. The analysis determines the overall system failure rate against the flight cycles. The process is agile to accommodate design changes with the evolution of architecture during the systems engineering lifecycle

Observing and Tracking the Great Pacific Garbage Patch

The subtropical waters between Hawaii and California are currently infested with an accumulation of plastic estimated to be twice the area of Texas, otherwise known as the Great Pacific Garbage Patch (GPGP). This paper presents a novel CubeSat mission to monitor the size, growth and position of the GPGP. At 1.6 million square kilometres, the GPGP is by far the largest and most serious accumulation of garbage out of the five patches littered across the world’s oceans. If we are to prevent further damage to the marine ecosystems, it is imperative we act with the utmost urgency. Leveraging recent technological advancements in imaging capabilities, a comprehensive concept of operations has been produced detailing the satellite\u27s lifecycle from launch to deorbit, including the crucial phases whereby data is collected and transmitted. Although this paper focuses on tracking and monitoring the GPGP, the same concept of operations has the potential to observe all five garbage patches. The proposed mission utilises two reflective indices, Normalised Difference Vegetation Index (NDVI) and Floating Debris Index (FDI), that will aid in differentiating surface plastics from other floating materials. For the mission to employ both NDVI and FDI, the chosen payload will require a spectral capture range from 665nm (red edge) to 1600nm (Short Wave Infrared) and would ideally have a Ground Sampling Distance (GSD) of no greater than 10m to guarantee the data collected is valuable

Targeting global environmental challenges by the means of novel multimodal transport: concept of operations

Novel modes of transport form the basis of environmentally friendly and economically efficient transport system of the future. This paper introduces the feasibility study of a Dock to Dock (D2D) use case, combining aspects of route development and infrastructure definition, for the transport of goods in South West England and South Wales. The proposed system makes use of new, more flexible and environmentally friendly means of transport, such as electric Vertical Take-Off and Landing (eVTOL) aircraft and electric Autonomous ZeroEmission (eAZE) vessels. To meet the environmental targets set out for the transport sector, the use of alternative hydrogen- based fuels is investigated for air, surface and marine vehicles. Logistics, regulations and infrastructure required for the safe and efficient production and distribution of such low-emission energy vectors is also considered. Digital twin of the system is proposed to study its safety and viability, while the analysis of energy requirements is proposed to inform policy makers and define the necessary infrastructure to meet future emission-free transport energy need

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

SpaceWire communications in power over Ethernet

This is a high-level study into the validation of a unified electric power and communications architecture for modern spacecraft systems. We leverage from blending the European Cooperation for Space Standardisation (ECSS) SpaceWire and the IEEE 802.3 Power over Ethernet (PoE) standards for a common on-board power and communications interface. The focus of the work has been communication performance. The requirements from the protocols of both standards were analysed and combined to create a full protocol stack for SpaceWire PoE. The stack is implemented on an embedded platform represented as a proof-of-concept SpaceWire PoE system. The results of functional testing demonstrate SpaceWire PoE as a valid solution that meets the requirements of both protocols. For the 100 Mb/s links, the SpaceWire PoE throughput is on a par (97.39%) with Ethernet (97.52%) and SpaceWire (99.2%). Shared communication and power architecture is intended for decentralised operation achieving greater autonomy of the integrated subsystems. This potentially may lead to standardisation of electrical, mechanical and communication interfaces across spacecraft subsystem manufacturers, easing harness complexity and routing during assembly, integration and test (AIT) phase of the spacecraft as well saving mass and launch cost

Energy harvesting from landing and taxiing of commercial aircraft

We demonstrate a virtual proof-of-concept design and experiment for energy harvesting enabling economic and environment-friendly aircraft by recycling forces for power conversion. The harvesting uses piezoelectric materials for extracting energy from the impact at the touchdown during the landing of an aircraft and direct current (DC) generators powered by the rotational motion of the aircraft wheels during taxiing. The design begins with a multidomain model comprising multibody dynamics, mathematical descriptions, abstract behavioral blocks, and programmed code. Piezoelectric harvesting explores six types of materials consisting of ring and disk pad geometries. Both geometries are typical configurations in suspension systems. Recent advances have shown the potential of getting higher voltage out of new materials properties. Our objective is to determine the useful impact force during a touchdown on the pads and a pad type that maximizes the power transfer. The evaluation shows that the American Piezo Ceramics (APC) 860/porous material in the ring shape gives the maximum power. For constant power generation during taxiing, we analyze four configurations of the DC generator. The DC generation offers a rich system-level design trade-off in evaluating a steady output voltage as the generator spins cyclically and changes flux in the coil during the contact between the wheel and the runway. The methodology for harvesting energy through touchdown and taxiing is agile to experiment with loads and their release heights for evaluating other piezoelectric materials for their potential for generating power as well as for the parametric tradespace analysis in generator performance