Polymorphism of the Tryptophan Hydroxylase 2 (TPH2) Gene Is Associated with Chimpanzee Neuroticism

In the brain, serotonin production is controlled by tryptophan hydroxylase 2 (TPH2), a genotype. Previous studies found that mutations on the TPH2 locus in humans were associated with depression and studies of mice and studies of rhesus macaques have shown that the TPH2 locus was involved with aggressive behavior. We previously reported a functional single nucleotide polymorphism (SNP) in the form of an amino acid substitution, Q468R, in the chimpanzee TPH2 gene coding region. In the present study we tested whether this SNP was associated with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively. Even after correcting for multiple tests (Bonferroni p = 0.05/6 = 0.008), Q468R was significantly related to higher neuroticism (β = 0.372, p = 0.005). This study is the first to identify a genotype linked to a personality trait in chimpanzees. In light of the prior studies on humans, mice, and rhesus macaques, these findings suggest that the relationship between neuroticism and TPH2 has deep phylogenetic roots

Calibration of transparency risks: a note

The aim of this research is to give a simple framework to evaluate/quantize the "transparency" of a firm. We assume that the process of the firm value is only observable once in a while but is strongly correlated with the stock price which is observable and tradable. This hybrid type structure make the transparency "observable". The implication of the present study is that the depth of the shock to the market caused by the precise accounting information does reflect the degree of transparency. Furthermore, it can be quantized resorting to the calibration method.

Association between cardiopulmonary resuscitation duration and one-month neurological outcomes for out-of-hospital cardiac arrest: a prospective cohort study

[Background]The duration of cardiopulmonary resuscitation (CPR) is an important factor associated with the outcomes for an out-of-hospital cardiac arrest. However, the appropriate CPR duration remains unclear considering pre- and in-hospital settings. The present study aimed to evaluate the relationship between the CPR duration (including both the pre- and in-hospital duration) and neurologically favorable outcomes 1-month after cardiac arrest. [Methods] Data were utilized from a prospective multi-center cohort study of out-of-hospital cardiac arrest patients transported to 67 emergency hospitals between January 2012 and March 2013 in the Kanto area of Japan. A total of 3, 353 patients with out-of-hospital cardiac arrest (age ≥18 years) who underwent CPR by emergency medical service personnel and achieved the return of spontaneous circulation in a pre- or in-hospital setting were analyzed. The primary outcome was a 1-month favorable neurological outcome. Logistic regression analysis was performed to estimate the influence of cardiopulmonary resuscitation duration. The CPR duration that achieved a cumulative proportion >99% of cases with a 1-month neurologically favorable outcome was determined. [Results] Of the 3, 353 eligible cases, pre-hospital return of spontaneous circulation was obtained in 1, 692 cases (50.5%). A total of 279 (8.3%) cases had a 1-month neurologically favorable outcome. The CPR duration was significantly and inversely associated with 1-month neurologically favorable outcomes with adjustment for pre- and in-hospital confounders (adjusted odds ratio: 0.911, per minute, 95% CI: 0.892–0.929, p 99%. [Conclusions] The CPR duration was independently and inversely associated with 1-month neurologically favorable outcomes after out-of-hospital cardiac arrest. The CPR duration required to achieve return of spontaneous circulation in >99% of out-of-hospital cardiac arrest patients with a 1-month favorable neurological outcome was 45 min, considering both pre- and in-hospital settings

Summary table of the subjects' sex, age, genotype, and personality <i>T</i>-score^†.

<p>Note.</p>†<p><i>Mean</i> = 50 and <i>SD</i> = 10. Dom = Dominance, Ext = Extraversion, Con = Conscientiousness, Agr = Agreeableness, Neu = Neuroticism, Opn = Openness.</p><p>*Other Japanese chimpanzees include 5 subjects from the Kyoto University Primate Research Institute, 2 subjects from the Higashiyama Zoo, 1 chimpanzee from the Itouzu-no-mori Zoo, 1 chimpanzee from the Kouchi Zoo, and 1 chimpanzee from the Tama Zoo.</p

Effect of Tryptophan hydroxylase 2 polymorphism on chimpanzee personality trait: Linear regression analysis with sex and age as the covariates.

<p>Note.</p>†<p>MAF: minor allele frequency.</p><p>*The combined samples includes 26 subjects from Chimpanzee Sanctuary Uto, 21 subjects from Guinea, and a total of 10 subjects from the Kyoto University Primate Research Institute (<i>n</i> = 5), Higashiyama Zoo (<i>n</i> = 2), Itouzu-no-mori Zoo (<i>n</i> = 1), Kouchi Zoo (<i>n</i> = 1), and Tama Zoo (<i>n</i> = 1). Boldfaced values indicate statistically significant effects (<i>p</i><.05). Underlined values indicate trends (<i>p</i><0.1).</p

Mean personality domain scores by genotype for chimpanzees living in Chimpanzee Sanctuary Uto, the sanctuary in Guinea, and the combined sample.

†<p>The combined samples includes 26 subjects from Chimpanzee Sanctuary Uto, 21 subjects from Guinea, and a total of 10 subjects from the Kyoto University Primate Research Institute (<i>n</i> = 5), Higashiyama Zoo (<i>n</i> = 2), Itouzu-no-mori Zoo (<i>n</i> = 1), Kouchi Zoo (<i>n</i> = 1), and Tama Zoo (<i>n</i> = 1).</p