ÉVALUATION DE L’ORAL CHEZ LES DÉBUTANTS EN FRANÇAIS LANGUE ÉTRANGÈRE : ÉTUDE DU JEU DE RÔLE

International audienceThis research focuses on the complexity of the evaluation of the oral performance in the context of learning French as a foreign language. From the perspective of Goffman's " frame analysis " , I'll try to identify the specifics of each situation and the ways in which candidates build their utterances while respecting the "scenario" and the juxtaposition of the focus of communication and metalinguistics

ÉVALUATION DE L’ORAL CHEZ LES DÉBUTANTS EN FRANÇAIS LANGUE ÉTRANGÈRE : ÉTUDE DU JEU DE RÔLE

International audienceThis research focuses on the complexity of the evaluation of the oral performance in the context of learning French as a foreign language. From the perspective of Goffman's " frame analysis " , I'll try to identify the specifics of each situation and the ways in which candidates build their utterances while respecting the "scenario" and the juxtaposition of the focus of communication and metalinguistics

Maternal hypertension after a low-birth-weight delivery differs by race/ethnicity: Evidence from the National Health and Nutrition Examination Survey (NHANES) 1999-2006

Studies have suggested an increase in maternal morbidity and mortality due to cardiovascular diseases in women with a prior low-birth-weight (LBW, <2,500 grams) delivery. This study evaluated blood pressure and hypertension in women who reported a prior preterm or small-for-gestational-age (SGA) LBW delivery in the National Health and Nutrition Examination Survey 1999-2006 (n = 6,307). This study also aimed to explore if race/ethnicity, menopause status, and years since last pregnancy modified the above associations. A total of 3,239 white, 1,350 black, and 1,718 Hispanics were assessed. Linear regression models were used to evaluate blood pressure by birth characteristics (preterm-LBW, SGA-LBW, and birthweight ≥2,500). Logistic regression models estimated the odds ratios (OR) of hypertension among women who reported a preterm-LBW or SGA-LBW delivery compared with women who reported an infant with birthweight ≥2,500 at delivery. Overall, there was a positive association between a preterm-LBW delivery and hypertension (adjusted OR = 1.39, 95% confidence interval (CI) 1.02-1.90). Prior SGA-LBW also increased the odds of hypertension, but the estimate did not reach statistical significance (adjusted OR = 1.21, 95% CI 0.76-1.92). Race/ethnicity modified the above associations. Only black women had increased risk of hypertension following SGA-LBW delivery (adjusted OR = 2.09, 95% CI 1.12-3.90). Black women were at marginally increased risk of hypertension after delivery of a preterm-LBW (adjusted OR = 1.49, 95% CI 0.93-2.38). Whites and Hispanics had increased, but not statistically significant, risk of hypertension after a preterm-LBW (whites: adjusted OR = 1.39, 95% CI 0.92-2.10; Hispanics: adjusted OR = 1.22, 95% CI 0.62-2.38). Stratified analysis indicated that the associations were stronger among women who were premenopausal and whose last pregnancy were more recent. The current study suggests that in a representative United States population, women with a history of preterm- or SGA-LBW deliveries have increased odds of hypertension and this risk appears to be higher for black women and younger women. © 2014 Xu et al

Cognitive Representation Learning of Self-Media Online Article Quality

The automatic quality assessment of self-media online articles is an urgent and new issue, which is of great value to the online recommendation and search. Different from traditional and well-formed articles, self-media online articles are mainly created by users, which have the appearance characteristics of different text levels and multi-modal hybrid editing, along with the potential characteristics of diverse content, different styles, large semantic spans and good interactive experience requirements. To solve these challenges, we establish a joint model CoQAN in combination with the layout organization, writing characteristics and text semantics, designing different representation learning subnetworks, especially for the feature learning process and interactive reading habits on mobile terminals. It is more consistent with the cognitive style of expressing an expert's evaluation of articles. We have also constructed a large scale real-world assessment dataset. Extensive experimental results show that the proposed framework significantly outperforms state-of-the-art methods, and effectively learns and integrates different factors of the online article quality assessment.Comment: Accepted at the Proceedings of the 28th ACM International Conference on Multimedi

SARS-CoV-2 Vaccine-Related Liver Failure: Active Hepatitis B and Comprehensive Literature Analysis

SARS-CoV-2 infection or vaccination is closely associated with liver injury, and autoimmune hepatitis episodes have been described, but liver failure has not been reported. Here, we report the case of a 41-year-old man, presenting with fatigue, anorexia after activity, greasy, decreased intake, yellow urine, and occasionally acid reflux in the stomach, occurring 2–3 weeks after receiving the first dose of inactivated SARS-CoV-2 vaccination, thought to be associated with his underlying chronic hepatitis B and fatty liver condition. The patient took the drug irregularly and did not achieve viral conversion to negative and appear rtA181T-resistant HBV mutation. Recently, the laboratory results showed abnormal liver function with high alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase (GGT), and there was no improvement in liver function after hepatoprotective therapy, and the serum hepatitis B virus (HBV) concentration was greater than 2.0 × 106 IU/mL. Later, after being admitted to our hospital, it was found that he was in, malaise, jaundice, his eyes and sclera were yellow, his lungs were coarse breath sounds, his liver function was abnormally elevated, and his HBV virus developed a drug-resistant mutation. He has no history of autoimmune disease and tests negative for autoimmune antibodies. He became severely ill after intermittently stopping HBV treatment, worsened liver injury after inactivated SARS-CoV-2 vaccination, and was diagnosed with acute-on-chronic liver failure (ACLF). By summarizing the case report, it will provide important information on the vaccine safety assessment of vaccine components, immunization routes, and dosage for people with underlying liver disease

FusionFormer: A Multi-sensory Fusion in Bird's-Eye-View and Temporal Consistent Transformer for 3D Objection

Multi-sensor modal fusion has demonstrated strong advantages in 3D object detection tasks. However, existing methods that fuse multi-modal features through a simple channel concatenation require transformation features into bird's eye view space and may lose the information on Z-axis thus leads to inferior performance. To this end, we propose FusionFormer, an end-to-end multi-modal fusion framework that leverages transformers to fuse multi-modal features and obtain fused BEV features. And based on the flexible adaptability of FusionFormer to the input modality representation, we propose a depth prediction branch that can be added to the framework to improve detection performance in camera-based detection tasks. In addition, we propose a plug-and-play temporal fusion module based on transformers that can fuse historical frame BEV features for more stable and reliable detection results. We evaluate our method on the nuScenes dataset and achieve 72.6% mAP and 75.1% NDS for 3D object detection tasks, outperforming state-of-the-art methods

Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy

The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photosensitizer chlorophenyl thiophene axially substituted silicon (IV) phthalocyanine (CBT-SiPc). CBT-SiPc showed specific targeting of lysosomes in living cells and good biocompatibility. Furthermore, high 1O2 generation efficiency and high PDT efficiency in MCF-7 breast cancers under irradiation were also demonstrated. The novel CBT-SiPc showed great potential in the application of lysosome-targeted and two-photon bioimaging-guided photodynamic cancer therapy

Using datamining approaches to selectacupoints in acupuncture and Moxibustion for knee osteoarthritis

Background: Acupuncture and moxibustion are traditional Chinese medicine therapies commonly used to treat knee osteoarthritis (KOA). Although acupoint selection affects the effectiveness of acupuncture and moxibustion, the basic rules of acupoint selection are little understood and there is a lack of guidelines regarding prescription. In this study, we used data mining approaches to investigate the principles of acupoint selection and provide a framework for formulation prescription in acupuncture and moxibustion for clinical treatment of KOA.Materials and Methods: PubMed, Cochrane Library, Science Citation Index, Wanfang database, VIP database, and China National Knowledge Infrastructure were searched for randomized controlled clinical trials published in English or Chinese from January 1, 2009 to October 1, 2015 evaluating the effect of acupuncture and moxibustion on KOA. Databases were established. Frequency statistics and association rule were used to extract and analyze the data.Results: A total of 876 acupuncture prescriptions and 122 acupoints were included in the analysis. Acupoints were concentrated in acupoints of fourteen meridians. The most frequently used acupoints were Dubi (ST35), Neixiyan (EX-LE4), Yanglingquan (GB34), Xuehai (SP10), Liangqiu (ST34), Zusanli (ST36), Yinlingquan (SP9), and Ashi point. The most frequently used meridian was Stomach Meridian of Foot-Yangming. Acupoints were concentrated mainly in the lower limbs. 42 acupoint pairs occurred frequently, and the top acupoint pairing was Dubi (ST35) and Neixiyan (EX-LE4).Conclusion: Acupoint selection and formulation prescription should focus on locally affected areas, and follow the theory of meridians, which helps establish guidelines for acupuncture and moxibustion in KOA patients.Key words: acupuncture and moxibustion, knee osteoarthritis, acupoint, data mining technolog

Effects of tumor necrosis factor-α polymorphism on the brain structural changes of the patients with major depressive disorder

Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if proinflammatory genetic burden adversely affects the regional gray matter volume in patients with MDD. The aim of this study was to test whether rs1799724, an SNP of TNF-α, contributes to the neuroanatomical changes in MDD. In this cross-sectional study, a total of 144 MDD patients and 111 healthy controls (HC) well matched for age, sex and education were recruited from Shanghai Mental Health Center. Voxel-based morphometry (VBM) followed by graph theory based structural covariance analysis was applied to locate diagnosis x genotype interactions. Irrespective of diagnosis, individuals with the high-risk genotype (T-carriers) had reduced volume in left angular gyrus (main effect of genotype). Diagnosis x genotype interaction was exclusively localized to the visual cortex (right superior occipital gyrus). The same region also showed reduced volume in patients with MDD than HC (main effect of diagnosis), with this effect being most pronounced in patients carrying the high-risk genotype. However, neither global nor regional network of structural covariance was found to have group difference. In conclusion, a genetic variation which can increase TNF-α expression selectively affects the anatomy of the visual cortex among the depressed subjects, with no effect on the topographical organization of multiple cortical regions. This supports the notion that anatomical changes in depression are in part influenced by the genetic determinants of inflammatory activity