6 research outputs found
Electrophysiological and pharmacological correspondence between expressed Kv4.2 current and rat cardiac transient outward current
Determinants of antiarrhythmic drug action: electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel
Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate
Deletion of highly conserved C-terminal sequences in the Kv1 <tex>K^{+}$</tex> channel subfamily does not prevent expression of currents with wildtype characteristics
AbstractThe C-terminal regions of Kv1 K+ channels show little conservation between isoforms except for the last four C-terminal residues, (E/L)TDV, which are well conserved from Drosophila to man. Deletions of the 4,16, and 57 C-terminal residues of the human Kv1.5 channel did not affect whole cell current amplitude, midpoint of activation, degree of inactivation, or activation kinetics following expression in mouse L-cells. Similar results were obtained with the rat Kv1.1 channel. Therefore, the conserved (E/L)TDV motif, and most of the C-terminal amino acids, are not required for Kv1 channel expression