Research and Prediction on the Sharing of WeChat Official Accounts’ Articles

With the development of mobile Internet, We Media was born. WeChat Official Account Platform is the largest we media platform in China. In WeChat social network, information can only be rapidly spread through the sharing operation of users. This paper takes WeChat official accounts as the object and uses logistic regression model to explore the influencing factors on sharing. After that, a prediction model is constructed based on logistic regression and support vector machine. The significance of this study is to propose the factors that influence WeChat official accounts’ articles sharing, and to construct a sharing prediction model

Viscosities of the crust and upper mantle constrained by three-dimensional GPS rates in the Sichuan–Yunnan fragment of China

Abstract The plastic flow in the Sichuan–Yunnan fragment (SYF) is the consequence of the eastern expansion of the Tibetan Plateau. The SYF area can be divided into three sections by the Xiaojin River fault zone and Red River fault zone, which both contain the normal fault component, consistent with GPS observations. The average vertical rates of the three sections exhibit a step-like distribution, and the southern subsidence rate is about 1–2 mm/year with respect to the northern area. To explain the vertical movement in the SYF, we subtract the vertical rates caused by the horizontal movement from the observed vertical rates and then use a two-layer viscous model to constrain the viscosities of the crust and upper mantle in the SYF. The fitting results between the vertical observed and model data show that the viscosity of the upper mantle is about 2.8 × 1022 Pa s and the viscosity of the crust is less than 1.0 × 1025 Pa s. Furthermore, we find that the vertical tectonic stresses dominate the driving mechanism for the vertical movement in the SYF

Evaluation of ASTER GDEM in the northeastern margin of Tibetan Plateau in gravity reduction

In this paper, we first transferred the normal height of ASTER GDEM v2 to GPS ellipsoidal height based on the EGM96, and analyzed the precision of this digital elevation model in the northeastern margin of Tibetan Plateau (NETP) combining with 89 ground GPS measurements. The results demonstrate that the standard deviation of the difference between ASTER GDEM and GPS results is 9.3 m, and the precision of ASTER GDEM in this region is approximately 10 m. We also calculated the free-air gravity anomalies using the relative gravity data and DEM model in NETP. The results show that the gravity anomalies are generally negative with local positive values, ranging from −156 to 43 mGal (10−5 m/s2). At last, we compared the EGM2008 free-air gravity anomalies (FGAs) with the ground gravity measurements, and their spatial patterns are similar. While the point-to-point difference between the modeling and measuring results shows great discrepancy. The free-air gravity anomalies of EGM2008 in this region range from −154 to 96 mGal, and the difference between EGM2008 and the ground measurements ranges from −102 to 50 mGal. The mean difference is −17.34 mGal, and the standard deviation is 46.69 mGal, which demonstrates that the EGM2008 has poor precision in the northeastern margin of Tibet Plateau

Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation

Abstract Background Chronic noise exposure has been associated with tau hyperphosphorylation and Alzheimer’s disease (AD)-like pathological changes, but the underlying mechanism is unknown. In this study, we explored the effects of long-term noise exposure on the corticotropin-releasing factor (CRF) system in the hippocampus and its role in noise-induced tau phosphorylation. Methods Sixty-four rats were randomly divided into the noise-exposed group and the control group, and rats in the exposure group were exposed to 95 dB SPL white noise for 30 consecutive days. The levels of CRF, CRFR1, CRFR2, and total tau and phosphorylated tau (p-tau) at Ser396 (S396) and Thr205 (T205) in the hippocampus were measured at different time points after the final noise exposure. The co-localized distribution of CRF and p-tau (T205) in the hippocampus was evaluated using double-labeling immunofluorescence. Results Long-term exposure to noise for 30 consecutive days significantly increased the expression of CRF and CRFR1 and their mRNAs levels in the hippocampus, which persisted for 7 days after final exposure. In contrast, CRFR2 was raised for 3–7 days following the last exposure. These alterations were also concomitant with the phosphorylation of tau at S396 and T205. Furthermore, there was co-localization of p-tau and CRF in hippocampal neurons. Conclusion Chronic noise leads to long-lasting increases in the hippocampal CRF system and the hyperphosphorylation of tau in the hippocampus. Our results also provide evidence for the involvement of the CRF system in noise-induced AD-like neurodegeneration

The Use of Cabozantinib in Advanced Hepatocellular Carcinoma in Hong Kong—A Territory-Wide Cohort Study

(1) Background: Cabozantinib is approved in sorafenib-exposed advanced hepatocellular carcinoma (aHCC). We evaluated the real-life pattern of use, efficacy, and tolerability of cabozantinib in aHCC. (2) Methods: This territory-wide study included consecutive aHCC patients who received cabozantinib between February 2018 and September 2020 in Hong Kong. The objective response rate (ORR), disease control rate (DCR), overall survival (OS), and adverse events (AE) were assessed. (3) Results: Overall, 42 patients were included. Approximately 83.3% had Child-Pugh A cirrhosis. About 64.3% received cabozantinib as a single agent, and the remaining 35.7% received cabozantinib as an add-on to immune checkpoint inhibitors (ICIs). For single-agent patients, the median follow-up was 6.7 months. The ORR was 3.7%, DCR was 44.4%, and the median OS was 8.28 months. About 74.1% of patients experienced any AEs with 7.4% having grade ≥3 AEs. Among patients who received prior ICIs (n = 16), the ORR was 6.3%, and the median OS was 8.28 months. An exploratory analysis of patients who received cabozantinib as an add-on to ICIs showed an ORR of 6.7% and a median OS of 15.1 months, with 73.3% having any AE and 13.3% having grade ≥3 AEs. (4) Conclusions: Cabozantinib had good anti-tumor activity, survival benefits, and acceptable tolerability in real-life aHCC patients