4,667 research outputs found
A Taxonomy of Hyperlink Hiding Techniques
Hidden links are designed solely for search engines rather than visitors. To
get high search engine rankings, link hiding techniques are usually used for
the profitability of black industries, such as illicit game servers, false
medical services, illegal gambling, and less attractive high-profit industry,
etc. This paper investigates hyperlink hiding techniques on the Web, and gives
a detailed taxonomy. We believe the taxonomy can help develop appropriate
countermeasures. Study on 5,583,451 Chinese sites' home pages indicate that
link hidden techniques are very prevalent on the Web. We also tried to explore
the attitude of Google towards link hiding spam by analyzing the PageRank
values of relative links. The results show that more should be done to punish
the hidden link spam.Comment: 12 pages, 2 figure
Matrix decomposition by transforming the unit sphere to an Ellipsoid through Dilation, Rotation and Shearing
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Measuring Electric Charge and Molecular Coverage on Electrode Surface from Transient Induced Molecular Electronic Signal (TIMES).
Charge density and molecular coverage on the surface of electrode play major roles in the science and technology of surface chemistry and biochemical sensing. However, there has been no easy and direct method to characterize these quantities. By extending the method of Transient Induced Molecular Electronic Signal (TIMES) which we have used to measure molecular interactions, we are able to quantify the amount of charge in the double layers at the solution/electrode interface for different buffer strengths, buffer types, and pH values. Most uniquely, such capabilities can be applied to study surface coverage of immobilized molecules. As an example, we have measured the surface coverage for thiol-modified single-strand deoxyribonucleic acid (ssDNA) as anchored probe and 6-Mercapto-1-hexanol (MCH) as blocking agent on the platinum surface. Through these experiments, we demonstrate that TIMES offers a simple and accurate method to quantify surface charge and coverage of molecules on a metal surface, as an enabling tool for studies of surface properties and surface functionalization for biochemical sensing and reactions
Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine
S-nitrosoglutathione reductase (GSNOR), a ubiquitously expressed protein central to the control of protein S-nitrosylation, plays critical roles in many biological systems. We showed recently that GSNOR is often deficient in human hepatocellular carcinoma and that germ line deletion of the GSNOR gene in mice causes hepatocellular carcinoma through S-nitrosylation and proteasomal degradation of the key DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). We report here the generation of mice with targeted deletion of GSNOR in hepatocytes or in cells of the hematopoietic lineage. We found that during inflammatory responses induced by intraperitoneal injection of diethylnitrosamine (DEN) or lipopolysaccharide, the amount of liver AGT was not changed in mice with GSNOR deletion in hematopoietic cells but was almost completely depleted in mice with GSNOR deletion in hepatocytes. In livers of DEN-challenged mice, GSNOR deletion in hepatocytes but not hematopoietic cells resulted in an increase in phosphorylated histone H2AX, a well-established marker of DNA double-strand breaks. Hepatocyte deletion of GSNOR increased DEN-induced mortality, which was abolished in mice deficient in both GSNOR and inducible nitric oxide synthase. Thus, protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes. In addition, our findings suggest that nitrosative inactivation of AGT from GSNOR deficiency might sensitize cancerous cells to alkylating drugs in cancer treatment
MIN-COST WITH DELAY SCHEDULING FOR LARGE SCALE CLOUD-BASED WORKFLOW APPLICATIONS PLATFORM
Cloud computing is a promising solution to provide the resource scalability dynamically. In order to support large scale workflow applications, we present Nuts-LSWAP which is implementation for Cloud workflow. Then, a novel Min-cost with delay scheduling algorithm is presented in this paper. We also focuses on the global scheduling including genetic evolution method and other scheduling methods (sequence and greedy) to evaluate and decrease the execution cost. Finally, three primary experiments divided into two parts. One parts of experiment demonstrate the global mapping algorithm effectively, and the second parts compare execution of a large scale workflow instances with or without delay scheduling. It is primarily proved the Nuts-LSWAP is efficient platform for building Cloud workflow environment
Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database
3D BLAST, a novel protein structure database search tool, is a useful tool for analysing novel structures, capable of returning a list of aligned structures ordered according to E-values
Deferoxamine retinopathy: spectral domain-optical coherence tomography findings
Al-Djamiʿ li Ibn al-BaïtharNumérisation effectuée à partir d'un document de substitution
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