69 research outputs found
A New Benchmark and Reverse Validation Method for Passage-level Hallucination Detection
Large Language Models (LLMs) have shown their ability to collaborate
effectively with humans in real-world scenarios. However, LLMs are apt to
generate hallucinations, i.e., makeup incorrect text and unverified
information, which can cause significant damage when deployed for
mission-critical tasks. In this paper, we propose a self-check approach based
on reverse validation to detect factual errors automatically in a zero-resource
fashion. To facilitate future studies and assess different methods, we
construct a hallucination detection benchmark named PHD, which is generated by
ChatGPT and annotated by human annotators. Contrasting previous studies of
zero-resource hallucination detection, our method and benchmark concentrate on
passage-level detection instead of sentence-level. We empirically evaluate our
method and existing zero-resource detection methods on two datasets. The
experimental results demonstrate that the proposed method considerably
outperforms the baselines while costing fewer tokens and less time.
Furthermore, we manually analyze some hallucination cases that LLM failed to
capture, revealing the shared limitation of zero-resource methods.Comment: EMNLP2023 Finding
Exploiting Summarization Data to Help Text Simplification
One of the major problems with text simplification is the lack of
high-quality data. The sources of simplification datasets are limited to
Wikipedia and Newsela, restricting further development of this field. In this
paper, we analyzed the similarity between text summarization and text
simplification and exploited summarization data to help simplify. First, we
proposed an alignment algorithm to extract sentence pairs from summarization
datasets. Then, we designed four attributes to characterize the degree of
simplification and proposed a method to filter suitable pairs. We named these
pairs Sum4Simp (S4S). Next, we conducted human evaluations to show that S4S is
high-quality and compared it with a real simplification dataset. Finally, we
conducted experiments to illustrate that the S4S can improve the performance of
several mainstream simplification models, especially in low-resource scenarios.Comment: 13 pages, 4 figures, EACL 202
ISWI Remodelling of Physiological Chromatin Fibres Acetylated at Lysine 16 of Histone H4
ISWI is the catalytic subunit of several ATP-dependent chromatin remodelling factors that catalyse the sliding of nucleosomes along DNA and thereby endow chromatin with structural flexibility. Full activity of ISWI requires residues of a basic patch of amino acids in the N-terminal 'tail' of histone H4. Previous studies employing oligopeptides and mononucleosomes suggested that acetylation of the H4 tail at lysine 16 (H4K16) within the basic patch may inhibit the activity of ISWI. On the other hand, the acetylation of H4K16 is known to decompact chromatin fibres. Conceivably, decompaction may enhance the accessibility of nucleosomal DNA and the H4 tail for ISWI interactions. Such an effect can only be evaluated at the level of nucleosome arrays. We probed the influence of H4K16 acetylation on the ATPase and nucleosome sliding activity of Drosophila ISWI in the context of defined, in vitro reconstituted chromatin fibres with physiological nucleosome spacing and linker histone content. Contrary to widespread expectations, the acetylation did not inhibit ISWI activity, but rather stimulated ISWI remodelling under certain conditions. Therefore, the effect of H4K16 acetylation on ISWI remodelling depends on the precise nature of the substrate
Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. <i>aeruginosa</i>
Abstract The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence factors and formation of drug-resistant biofilms. Targeting the mechanism of QS has proven to be a functional alternative to conventional antibiotic control of infections. However, the presence of multiple QS systems in individual bacterial species poses a challenge to this approach. Quorum sensing inhibitors (QSI) and quorum quenching enzymes (QQE) have been both investigated for their QS interfering capabilities. Here, we first simulated the combination effect of QQE and QSI in blocking bacterial QS. The effect was next validated by experiments using AiiA as QQE and G1 as QSI on Pseudomonas aeruginosa LasR/I and RhlR/I QS circuits. Combination of QQE and QSI almost completely blocked the P. aeruginosa las and rhl QS systems. Our findings provide a potential chemical biology application strategy for bacterial QS disruption
The effect of socioeconomic status on three-year mortality after first-ever ischemic stroke in Nanjing, China
BACKGROUND: Low socioeconomic status (SES) is associated with increased mortality after stroke in developed countries. This study was performed to determine whether a similar association also exists in China. METHODS: A total of 806 patients with first-ever ischemic stroke were enrolled in our study. From August 1999 to August 2005, the three-year all-cause mortality following the stroke was determined. Level of education, occupation, taxable income and housing space were used as indicators for SES. Stepwise univariate and multivariate COX proportional hazards models were used to study the association between the SES measures and the three-year mortality. RESULTS: Our analyses confirmed that occupation, taxable income and housing space were significantly associated with three-year mortality after first-ever stroke. Manual workers had a significant hazard ratio of 5.44 (95% CI 2.75 to 10.77) for death within three years when compared with non-manual workers. Those in the zero income group had a significant hazard ratio of 5.35 (95% CI 2.95 to 9.70) and those in the intermediate income group 2.10 (95% CI 1.24 to 3.58) when compared with those in the highest income group. Those in two of the three groups with the smallest housing space also had significant hazard ratios of 2.06 (95% CI 1.16 to 3.65) and 1.68 (95% CI 1.12 to 2.52) when compared with those in group with the largest housing space. These hazard ratios remained largely unchanged after multivariate adjustment for age, gender, baseline cardiovascular disease risk factors, and stroke severity. The analyses did not confirm an association with educational level. CONCLUSION: Lower SES has a negative impact on the outcome of first-ever stroke in Nanjing, China. This confirms the need to improve preventive and secondary care for stroke among low SES groups
The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association
Understanding the molecular mechanisms behind regulation of chromatin folding through covalent modifications of the histone N-terminal tails is hampered by a lack of accessible chromatin containing precisely modified histones. We study the internal folding and intermolecular self-association of a chromatin system consisting of saturated 12-mer nucleosome arrays containing various combinations of completely acetylated lysines at positions 5, 8, 12 and 16 of histone H4, induced by the cations Na+, K+, Mg2+, Ca2+, cobalt-hexammine3+, spermidine3+ and spermine4+. Histones were prepared using a novel semi-synthetic approach with native chemical ligation. Acetylation of H4-K16, but not its glutamine mutation, drastically reduces cation-induced folding of the array. Neither acetylations nor mutations of all the sites K5, K8 and K12 can induce a similar degree of array unfolding. The ubiquitous K+, (as well as Rb+ and Cs+) showed an unfolding effect on unmodified arrays almost similar to that of H4-K16 acetylation. We propose that K+ (and Rb+/Cs+) binding to a site on the H2B histone (R96-L99) disrupts H4K16 ε-amino group binding to this specific site, thereby deranging H4 tail-mediated nucleosome–nucleosome stacking and that a similar mechanism operates in the case of H4-K16 acetylation. Inter-array self-association follows electrostatic behavior and is largely insensitive to the position or nature of the H4 tail charge modification
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovatio
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