3 research outputs found
(±)-Aspongamide A, an <i>N</i>‑Acetyldopamine Trimer Isolated from the Insect <i>Aspongopus chinensis,</i> Is an Inhibitor of p‑Smad3
(±)-Aspongamide
A (<b>1</b>), an unusual trimer of <i>N</i>-acetyldopamine
(NADA) bearing a novel tetrahydrobenzo[<i>a</i>]dibenzo[<i>b</i>,<i>e</i>][1,4]dioxine
structure, and a pair of NADA dimeric enantiomers (<b>2</b>)
were isolated from <i>Aspongopus chinensis</i>. The structures
of compounds <b>1</b> and <b>2</b> were assigned using
spectroscopic methods. Compound <b>1</b> was found to be an
inhibitor of Smad3 phosphorylation in transforming growth factor-β1
(TGF-β1) induced rat renal proximal tubular cells and suppressed
extracellular matrix expression in mesangial cells under diabetic
conditions
Supplementary material for: Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery
Supplementary files for Maciá-Vicente et al. (2018) Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery. Environmental Microbiology, doi: 10.1111/1462-2920.1407
Chemical constituents from <i>Piper wallichii</i>
<div><p>Fifteen known compounds including four triterpenoids (<b>1</b>–<b>4</b>), one sterol (<b>5</b>), one diketopiperazine alkaloid (<b>6</b>) and nine phenolics (<b>7</b>–<b>15</b>) were isolated from the stems of <i>Piper wallichii</i>. Their structures were elucidated by means of spectroscopic analysis, and acidic hydrolysis in case of the 2-oxo-3β,19α,23-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (<b>1</b>). The structure of compound <b>1</b> was fully assigned by 1D and 2D NMR experiments for the first time. All isolates were tested for their antibacterial, antifungal, anti-inflammatory and antiplatelet aggregation bioactivities.</p></div