Qualidade da interação professor-aluno no 1.º ciclo do ensino básico: do diálogo experiencial à educação emocional.

Na interação professor-aluno, a qualidade do diálogo estabelecido pode potenciar a escuta, a partilha, o reconhecimento e a compreensão de emoções, dimensões conducentes a uma melhoria do processo de ensino-aprendizagem em contexto de sala de aula e consequentemente ao desenvolvimento de um trabalho ao nível da educação emocional das crianças. A interação professor-aluno que crie as condições necessárias para uma educação emocional com sucesso é o foco do nosso projeto. O diálogo experiencial/sensibilidade é a dimensão em estudo e compreende os indicativos de autenticidade, aceitação e empatia. Com o presente estudo, financiado pela Fundação para a Ciência e Tecnologia (FCT) e apoiado pelo Centro de Investigação Didática e Tecnologia na Formação de professores pretende-se trazer uma contribuição para a promoção do bem-estar emocional de crianças e professores em sala de aula. Assim esta investigação, sendo um estudo exploratório e descritivo, insere-se numa metodologia qualitativa e no paradigma fenomenológico-interpretativo. Este estudo pretende conhecer a perceção de uma amostra de professores portugueses sobre as interações professor-aluno que possibilitam uma educação emocional com sucesso, e compreender e analisar as estratégias de promoção da educação emocional em contexto escolar. O estudo decorre em duas fases. Na fase I, a foram aplicados inquéritos por questionário a 91 professores de 5 agrupamentos de escolas do 1.º ciclo do ensino básico da zona centro do país. Na fase II, e com base nos resultados da fase I do estudo, será retirada uma amostra mais pequena de 8 docentes para realização de entrevistas focus group e narrativas de situação. A análise preliminar dos dados demonstra uma prevalência de docentes interessados em desenvolver atividades de educação emocional em sala de aula mas uma percentagem reduzida a fazê-lo. Pretende-se com este trabalho contribuir para a promoção do bem-estar emocional de crianças e professores em sala de aula.info:eu-repo/semantics/publishedVersio

New scheduling algorithms and digital tool for dynamic permutation flowshop with newly arrived order

<p>The permutation flowshop scheduling problem has been widely studied under static environment by assuming machines and jobs are available at the time of zero. However, in reality, new orders arrive at production systems randomly, which leads to sheer complexity in scheduling due to the dynamic changes given various constraints of resources. Previous studies simply attach new orders directly after the existing schedule. Recent study shows mixing jobs of old and new orders could result in better scheduling solutions. But the heuristic algorithms are still lacking to implement the job mixing policy. To address this problem, a novel scheduling strategy is herein proposed by integrating match-up strategy and real-time strategy (MR) in order to make use of the remaining time before the old order due date. Based on the new MR strategy, eleven new heuristics are introduced with ten existing and one new priority rules. Computational results illustrate the effectiveness of the new heuristics. A digital tool is developed for ease of application of these heuristics, and it is validated by case studies.</p

Gold-Nanorod-Based Colorimetric and Fluorescent Approach for Sensitive and Specific Assay of Disease-Related Gene and Mutation

Sensitive and specific detection of disease-related gene and single nucleotide polymorphism (SNP) is of great importance in cancer diagnosis. Here, a colorimetric and fluorescent approach is described for detection of the p53 gene and SNP in homogeneous solution by using gold nanorods (GNRs) as both colorimetric probe and fluorescence quencher. Hairpin oligonucleotide was utilized as DNA probe to ensure highly sequence-specific detection of target DNA. In the presence of target DNA, the formation of DNA duplex greatly changed the electrostatic interaction between GNR and DNAs, leading to an obvious change in fluorescence and colorimetric response. The detection limit of fluorescent and colorimetric assay is 0.26 pM and 0.3 nM, respectively. Both fluorescence and colorimetric strategies were able to effectively discriminate complementary DNA from single-base mismatched DNA, which is meaningful for cancer diagnosis. More important, target DNA can be detected as low as 10 nM by the naked eye. Furthermore, transmission electron microscopy and fluorescence anisotropy measurements demonstrated that the color change as well as fluorescence quenching is ascribed to the DNA hybridization-induced aggregation of GNRs. Therefore, the assay provided a fast, sensitive, cost-effective, and specific sensing platform for detecting disease-related gene and SNP

Effect of Size-Selective Retention on the Cotransport of Hydroxyapatite and Goethite Nanoparticles in Saturated Porous Media

Attributable to their nanoscale size and slow phosphorus (P) release kinetics, hydroxyapatite nanoparticles (HANPs) are increasingly advocated as a promising P nanofertilizer. Additionally, HANPs have been extensively used to remediate soils, groundwater, and nuclear wastewaters contaminated with metals and radionuclides. Increasing application of HANPs for agronomic and environmental advantages will expedite their dissemination in subsurface environments. Because the biogeochemical cycling of P is intimately coupled with iron, it is anticipated that HANPs and released P from HANPs interact with iron oxides, particularly naturally occurring goethite nanoparticles (GNPs) because of their nanoscale size and high reactivity toward P. Here, we investigated the cotransport and retention of HANPs and GNPs in water-saturated sand columns under environmentally relevant transport conditions (pH and natural organic matter type and concentration). Our results indicated that the “size-selective retention”, i.e., preferential retention of larger particles near the column inlet and elution of smaller particles occurred during cotransport of HANPs and GNPs, and the cotransport of both NPs is highly sensitive to solution chemistry that determines NPs dissolution, homo- and heteroaggregation, and co- and competitive-retention. These findings have important insights into application of HANPs as a promising P nanofertilizer and an in situ amendment for contaminated site remediation

Diagnostic monitoring of high-dimensional networked systems via a LASSO-BN formulation

<p>Quality control of multivariate processes has been extensively studied in the past decades; however, fundamental challenges still remain due to the complexity and the decision-making challenges that require not only sensitive fault detection but also identification of the truly out-of-control variables. In existing approaches, fault detection and diagnosis are considered as two separate tasks. Recent developments have revealed that selective monitoring of the potentially out-of-control variables, identified by a variable selection procedure combined with the process monitoring method, could lead to promising performances. Following this line, we propose the diagnostic monitoring that takes an additional step on from the selective monitoring idea and directs the monitoring effort on the potentially out-of-control variables. The identification of the truly out-of-control variables can be achieved by integrating the process monitoring formulation with process cascade knowledge represented by a Bayesian Network. Computationally efficient algorithms are developed for solving the optimization formulation with connection to the Least Absolute Shrinkage and Selection Operator (LASSO) problem being identified. Both theoretical analysis and extensive experiments on a simulated data set and real-world applications are conducted that show the superior performance.</p

Nanoparticle-Aided Amplification of Fluorescence Polarization for Ultrasensitively Monitoring Activity of Telomerase

To realize facile and reliable analyzing telomerase activity in homogeneous, herein, for the first time, a fluorescent polarization (FP) strategy was developed for polymerase chain reaction (PCR) free monitoring activity of human telomerase at single-cell level ground on gold nanoparticle (GNP) enhancement of FP. First, thiolated telomerase substrate (TS) primer is modified to the surface of GNP via Au–S bond. In the presence of telomerase, TS primer was extended via adding hexamer repeats (GGGTTA), leading to the formation of a long elongation DNA. Several short carboxyfluorescein (FAM)-modified complementary DNA (F-cDNA) can hybridize with the hexamer repeats, resulting in a sharp increase in FP value. Because of the GNP enhancement and self-amplification of telomerase, telomerase activity accounting to one HeLa cell can be rapidly detected in homogeneous solution. Telomerase activities of various cell lines were also favorably estimated. Meanwhile, the inhibition efficiency of telomerase inhibitor was studied, which holds great potential in screening telomerase-targeted anticancer drugs as well. So, a facile method was put forward to reliably and ultrasensitively detect telomerase activity

Data_Sheet_1_Risk factors of Carbapenem-resistant Enterobacterales intestinal colonization for subsequent infections in hematological patients: a retrospective case-control study.docx

ObjectiveInfections caused by Carbapenem-resistant Enterobacterales (CRE) have high treatment costs, high mortality and few effective therapeutic agents. This study aimed to determine the risk factors for progression from intestinal colonization to infection in hematological patients and the risk factors for 30-day mortality in infected patients.MethodsA retrospective case-control study was conducted in the Department of Hematology at Shandong Provincial Hospital affiliated to Shandong First Medical University from April 2018 to April 2022. Patients who developed subsequent infections were identified as the case group by electronic medical record query of patients with a positive rectal screen for CRE colonization, and patients who did not develop subsequent infections were identified as the control group by stratified random sampling. Univariate analysis and logistic regression analysis determined risk factors for developing CRE infection and risk factors for mortality in CRE-infected patients.ResultsEleven hematological patients in the study developed subsequent infections. The overall 30-day mortality rate for the 44 hematological patients in the case-control study was 11.4% (5/44). Mortality was higher in the case group than in the control group (36.5 vs. 3.0%, P = 0.0026), and septic shock was an independent risk factor for death (P = 0.024). Univariate analysis showed that risk factors for developing infections were non-steroidal immunosuppressants, serum albumin levels, and days of hospitalization. In multivariable logistic regression analysis, immunosuppressants [odds ratio (OR), 19.132; 95% confidence interval (CI), 1.349–271.420; P = 0.029] and serum albumin levels (OR, 0.817; 95% CI, 0.668–0.999; P = 0.049) were independent risk factors for developing infections.ConclusionOur findings suggest that septic shock increases mortality in CRE-infected hematological patients. Hematological patients with CRE colonization using immunosuppressive agents and reduced serum albumin are more likely to progress to CRE infection. This study may help clinicians prevent the onset of infection early and take measures to reduce mortality rates.</p

Table_2_Pegbelfermin for reducing transaminase levels in patients with non-alcoholic steatohepatitis: a dose-response meta-analysis of randomized controlled trials.DOCX

BackgroundThe efficacy of Pegbelfermin (PGBF) in treating non-alcoholic steatohepatitis (NASH) remains controversial. Therefore, we conducted a dose-response meta-analysis to explore the effect and pattern of PGBF at different dosages and treatment durations on transaminase reduction in NASH patients.MethodsWe conducted searches on PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov, and supplemented the search with gray literature and manual searches. Randomized controlled trials (RCTs) evaluating the efficacy of PGBF in NASH patients were included. Risk of bias was assessed by Cochrane Risk of Bias Tool 2.0. We used random-effects models, generalized least squares regression, constrained maximum likelihood, and restricted cubic splines to explore the dose-response relationship. Egger's linear regression was employed to assess publication bias. The study is registered with PROSPERO, CRD42023448024.ResultsFour RCT studies from the period 2018–2023, involving 546 participants, were included. No participants discontinued PGBF treatment due to adverse events. High-dose PGBF treatment significantly reduced transaminase levels in NASH patients compared to the low-dose group (ALT %: MD = 14.94, 95% CI = 2.11–27.77; AST %: MD = 9.05, 95% CI = 3.17–14.92). Longer treatment duration further decreased transaminase levels (ALT%: MD = 8.81, 95% CI = 4.07–13.56; AST%: MD = 6.72, 95% CI = 2.62–10.81). Egger's test did not reveal significant publication bias (p > 0.05). Further investigation indicated a ceiling effect of PGBF dosage on transaminase reduction at 30 mg/week, and NASH patients experienced a rebound in transaminase levels after 28 weeks of continuous treatment.ConclusionThere is a positive correlation between PGBF dosage and transaminase reduction within a certain range, showing an overall non-linear dose-response relationship. This finding provides guidance for the clinical application of PGBF. Clinicians should be mindful of the dosage ceiling at 30 mg/week and monitor changes in transaminase levels after 28 weeks for timely adjustments in PGBF dosage.Systematic review registrationPROSPERO, CRD42023448024. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=448024</p

In Situ AFM Imaging of Solid Electrolyte Interfaces on HOPG with Ethylene Carbonate and Fluoroethylene Carbonate-Based Electrolytes

Chemical and morphological structure of solid electrolyte interphase (SEI) plays a vital role in lithium-ion battery (LIB), especially for its cyclability and safety. To date, research on SEI is quite limited because of the complexity of SEI and lack of effective in situ characterization techniques. Here, we present real-time views of SEI morphological evolution using electrochemical atomic force microscopy (EC-AFM). Complemented by an ex situ XPS analysis, fundamental differences of SEI formation from ethylene carbonate (EC) and fluoroethylene carbonate (FEC)-based electrolytes during first lithiation/delithiation cycle on HOPG electrode surface were revealed

Table_1_Pegbelfermin for reducing transaminase levels in patients with non-alcoholic steatohepatitis: a dose-response meta-analysis of randomized controlled trials.DOCX

BackgroundThe efficacy of Pegbelfermin (PGBF) in treating non-alcoholic steatohepatitis (NASH) remains controversial. Therefore, we conducted a dose-response meta-analysis to explore the effect and pattern of PGBF at different dosages and treatment durations on transaminase reduction in NASH patients.MethodsWe conducted searches on PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov, and supplemented the search with gray literature and manual searches. Randomized controlled trials (RCTs) evaluating the efficacy of PGBF in NASH patients were included. Risk of bias was assessed by Cochrane Risk of Bias Tool 2.0. We used random-effects models, generalized least squares regression, constrained maximum likelihood, and restricted cubic splines to explore the dose-response relationship. Egger's linear regression was employed to assess publication bias. The study is registered with PROSPERO, CRD42023448024.ResultsFour RCT studies from the period 2018–2023, involving 546 participants, were included. No participants discontinued PGBF treatment due to adverse events. High-dose PGBF treatment significantly reduced transaminase levels in NASH patients compared to the low-dose group (ALT %: MD = 14.94, 95% CI = 2.11–27.77; AST %: MD = 9.05, 95% CI = 3.17–14.92). Longer treatment duration further decreased transaminase levels (ALT%: MD = 8.81, 95% CI = 4.07–13.56; AST%: MD = 6.72, 95% CI = 2.62–10.81). Egger's test did not reveal significant publication bias (p > 0.05). Further investigation indicated a ceiling effect of PGBF dosage on transaminase reduction at 30 mg/week, and NASH patients experienced a rebound in transaminase levels after 28 weeks of continuous treatment.ConclusionThere is a positive correlation between PGBF dosage and transaminase reduction within a certain range, showing an overall non-linear dose-response relationship. This finding provides guidance for the clinical application of PGBF. Clinicians should be mindful of the dosage ceiling at 30 mg/week and monitor changes in transaminase levels after 28 weeks for timely adjustments in PGBF dosage.Systematic review registrationPROSPERO, CRD42023448024. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=448024</p