The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer

Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer

Tkachenko P. V., Yakovtcova I. I., Dolgaya O. V., Ivakhno I. V. Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer. Journal of Education, Health and Sport. 2017;7(7):764-775. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.843519 http://ojs.ukw.edu.pl/index.php/johs/article/view/4700 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.07.2017. Revised: 02.07.2017. Accepted: 31.07.2017. Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer P. V. Tkachenko, I. I. Yakovtcova, O. V. Dolgaya, I. V. Ivakhno Kharkiv medical academy of postgraduate education Abstract Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p <0.05 and p <0.01, respectively). An inverse dependence between the reaction of vimentin and E-cadherin (p <0.05) and their correlation withTGFβ (p <0.05) was detected. Conclusion: community of the molecular-biological manifestations of the epithelial-mesenchymal transformation in prostate gland cancer and involvement of TGFβ into its process has been proved. Epithelial-mesenchymal transformation maybe a prognostic criterionof the disease. Key words: prostate gland cancer, vimentin, E-cadherin, TGFβ, epithelial-mesenchymal transformation