17,691 research outputs found
Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression
We present an analytical framework describing the steady-state distribution of protein concentration in live cells, considering that protein production occurs in random bursts with an exponentially distributed number of molecules. We extend this framework for cases of transcription autoregulation and noise propagation in a simple genetic network. This model allows for the extraction of kinetic parameters of gene expression from steady-state distributions of protein concentration in a cell population, which are available from single cell data obtained by flow cytometry or fluorescence microscopy
Radiative Neutrino Mass with Dark matter: From Relic Density to LHC Signatures
In this work we give a comprehensive analysis on the phenomenology of a
specific dark matter (DM) model in which neutrino mass is
induced at two loops by interactions with a DM particle that can be a complex
scalar or a Dirac fermion. Both the DM properties in relic density and direct
detection and the LHC signatures are examined in great detail, and indirect
detection for gamma-ray excess from the Galactic Center is also discussed
briefly. On the DM side, both semi-annihilation and co-annihilation processes
play a crucial role in alleviating the tension of parameter space between relic
density and direct detection. On the collider side, new decay channels
resulting from particles lead to distinct signals at LHC.
Currently the trilepton signal is expected to give the most stringent bound for
both scalar and fermion DM candidates, and the signatures of fermion DM are
very similar to those of electroweakinos in simplified supersymmetric models.Comment: 40 pages, 24 figure
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Systematic Scatterometer Wind Errors Near Coastal Mountains.
Satellite scatterometers provide the only regular observations of surface wind vectors over vast swaths of the world oceans, including coastal regions, which are of great scientific and societal interest but still present challenges for remote sensing. Here we demonstrate systematic scatterometer wind errors near Hawaii's Big Island: Two counter-rotating lee vortices, which are clear in the International Comprehensive Ocean-Atmosphere Data Set ship-based wind climatology and in aircraft observations, are absent in the Jet Propulsion Laboratory and Remote Sensing Systems scatterometer wind climatologies. We demonstrate similar errors in the representation of transient Catalina Eddy events in the Southern California Bight. These errors likely arise from the nonuniqueness of scatterometer wind observations, that is, an "ambiguity removal" is required during processing to select from multiple wind solutions to the geophysical model function. We discuss strategies to improve the ambiguity selection near coastal mountains, where small-scale wind reversals are common
Evolution of interactions and cooperation in the spatial prisoner's dilemma game
We study the evolution of cooperation in the spatial prisoner's dilemma game
where players are allowed to establish new interactions with others. By
employing a simple coevolutionary rule entailing only two crucial parameters,
we find that different selection criteria for the new interaction partners as
well as their number vitally affect the outcome of the game. The resolution of
the social dilemma is most probable if the selection favors more successful
players and if their maximally attainable number is restricted. While the
preferential selection of the best players promotes cooperation irrespective of
game parametrization, the optimal number of new interactions depends somewhat
on the temptation to defect. Our findings reveal that the "making of new
friends" may be an important activity for the successful evolution of
cooperation, but also that partners must be selected carefully and their number
limited.Comment: 14 pages, 6 figures; accepted for publication in PLoS ON
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