Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Concept and design of charged particle optics using energy Fourier plane collimation

Charged particle radiography has become a promising new approach in the field of transmission radiography because of the invention of the magnetic imaging lens. The using of the imaging lens makes it possible for thick objects to get significantly improved transmission radiography. Currently, the conventional charged particle radiography only uses the information of the flux attenuation and the angular scattering of the transmitted particles to determine the properties of the sample. However, the energy loss of the incident particles introduced by ionizations throughout the object limits the spatial resolution of the image because of the chromatic blur. In this paper a new concept of imaging lens that uses the information of the energy loss is proposed. With a specially designed imaging lens, the information of the energy loss could result in apparent contrast in the final image. This design procedure of the energy loss imaging lens is presented, and a preliminary design is verified by numerical simulations. Experimental demonstration is also expected on a cyclotron at the Institute of Fluid Physics, CAEP

Coverage and effectiveness of COVID-19 vaccines among people aged 60 years and above in Changning District of Shanghai

ObjectiveTo assess the coverage and effectiveness of COVID-19 vaccines in the elderly.MethodsThis study was conducted in Changning District of Shanghai， targeting people aged 60 years and above. Vaccination data between 21 December 2020 and 28 February 2022 was retrieved from the Shanghai Collective Immunization System. Information on confirmed cases of COVID-19 from March 2022 through May 2022 was collected from the National Notifiable Diseases Reporting System. Vaccine effectiveness was calculated using the screening method.ResultsAs of 28 February 2022， 69.89% of people aged ≥60 years had received ≥1-dose vaccine， 63.80% had received full primary vaccination and 31.91% had received a booster dose. Vaccination coverage declined over age， with the lowest coverage in the elderly aged ≥80 years. Moreover， COVID-19 vaccination provided the highest protection against severe/critical illness and death due to the Omicron variants in the elderly aged ≥60 years. Full primary vaccination showed 96.15%（95%CI：84.15‒99.06）of vaccine effectiveness and booster vaccination showed 100% of the effectiveness against severe/critical COVID-19 and death.ConclusionsFull primary and booster vaccination coverage in the elderly is low， especially in those aged 80 and above. Our study finds high protection against COVID-19 associated severe/critical illness and death from both full primary and booster vaccination of inactivated COVID-19 vaccines in the elderly aged ≥60 years