A Deep few-shot learning algorithm for hyperspectral image classification

For hyperspectral image classification problem of small sample, this paper proposes a depth of less sample learning algorithm, this algorithm through the simulation of the small sample classification in the process of training is to train the depth 3D convolution neural network feature extraction, the extraction of characteristic with smaller class span and large spacing between classes, more suitable for small sample classification problem, and can be used for different hyperspectral data, has better generalization ability. The trained model is used to extract the features of the target data set, and then the nearest neighbor classifier and support vector machine classifier are combined for supervised classification. Three groups of hyperspectral image data of Pavia university, Indian Pines and Salinas were used in the classification experiment. The experimental results showed that the algorithm could achieve a better classification accuracy than the traditional semi-supervised classification method under the condition of fewer training samples (only 5 marked samples were selected for each type of feature as training samples)

Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways

Liver ischemia and reperfusion (I/R) induce local and distant tissue injuries, contributing to morbidity and mortality in a wider range of pathologies. This is especially seen under uncontrolled aseptic inflammatory conditions, leading to injury of remote organs, such as lung injury, and even failure. Saquinavir (SQV) is a kind of HIV protease inhibitor that possesses an anti-inflammatory property. In this study, we investigated whether SQV suppresses Toll-like receptor 4- (TLR4-) dependent signaling pathways of high-mobility group box 1 (HMGB1) and P38/JNK, conferring protection against murine liver I/R-induced lung injury. To investigate our hypothesis, C57BL/6 mice and TLR4 knockout mice (TLR4−/−) were used to perform the study. SQV administration markedly attenuated remote lung tissue injury after 1-hour ischemia and 6-hour reperfusion of the liver. To our expectation, SQV attenuated I/R-induced lung edema, hyperpermeability, and pathological injury. The beneficial effects of SQV were associated with decreased levels of circulating and lung tissue inflammatory cytokines, such as IL-6, IL-1β, TNF-α, and iNOS. The protective effect of SQV was also associated with decreased lung tissue expression of HMGB1, TLR-4, and p-P38/JNK, but not p-ERK in wild-type liver I/R mice. Overall, this study demonstrated a new role of SQV, facilitating negative regulation of HMGB1- and P38/JNK-mediated TLR-4-dependent signaling pathways, conferring protection against liver I/R-induced lung injury

Effect of TiC Content on Microstructures and Properties of Laser Cladding TiC/Ti Based Composite Coatings

To improve the corrosion resistance and load-bearing performance of titanium alloy, the TiC/Ti based composite coating with good metallurgical quality was prepared on the surface of TC4 titanium alloy by using Diode laser, and the effect of TiC content on the microstructures and properties of TiC/TC4 cladding was studied. The microstructure and phase constitution of the coating were characterized by scanning electron microscope (SEM) and X-ray diffraction (XRD), the micro-hardness, corrosion resistance and the load-bearing performance of the coatings were evaluated. The results show that the cladding consists of TiC, TiC0.95, NiTi2 and α'-Ti, and the overall hardness of the coating fluctuates greatly. The micro-hardness in hard phases and in the heat affected zone are 1000-1500HV and about 437HV respectively. While the mass fraction of Ni coated TiC is not higher than 60%, higher corrosion resistance of claddings can be obtained with the increase of the mass fraction of Ni coated TiC, reaching a maximum at 60%; while the mass fraction of Ni coated TiC is not higher than 50%, the load-bearing capacity of claddings can be improved with the increase of the mass fraction of TiC, reaching a maximum at 50%

WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice

Abstract Background Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca2+ overload and neutrophil infiltration, have been implied in the pathogenesis of liver and remote organ injuries following reperfusion. WNT1 inducible signaling pathway protein 1 (WISP1) is an extracellular matrix protein that has been associated with the onset of several malignant diseases. Previous work in our group has demonstrated WISP1 is upregulated and contributes to proinflammatory cascades in hepatic IRI. However, the role of WISP1 in the pathogenesis of lung injury after hepatic IRI still remains unknown. Methods Male C57BL/6 mice were used to examine the expression and role of WISP1 in the pathogenesis of lung injuries after hepatic IRI and explore its potential mechanisms in mediating lung injuries. Results We found WISP1 was upregulated in lung tissues following hepatic IRI. Treatment with anti-WISP1 antibody ameliorated lung injuries with alteration of cytokine profiles. Administration with rWISP1 aggravated lung injuries following hepatic IRI through excessive production of proinflammatory cytokines and inhibition of anti-inflammatory cytokines. Conclusions In this study, we concluded that WISP1 contributed to lung injuries following hepatic IRI through TLR4 pathway

Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)­indoles and 2-(2-aminoethyl)­pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome

Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)­indoles and 2-(2-aminoethyl)­pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome

Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)­indoles and 2-(2-aminoethyl)­pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome

ZnO QUANTUM DOT HYBRID LUMINESCENT RESISTS FOR NANOIMPRINT LITHOGRAPHY

We report the preparation of ZnO quantum dot hybrid luminescent resists for nanoimprint lithography. Photoluminescence spectra indicate that ZnO QDs@AMONIL have a significant increase in the luminescent intensity, an obvious blue-shift of emission peak and the Stoke's shift, revealing that ZnO QDs@AMONIL have dramatic luminescent property change instead of inhibiting or only preserving the optical properties of pure ZnO QDs. The fabrication of two-dimensional (2D) photonic crystal structure on the ZnO QDs@AMONIL by UV-based nanoimprint lithography is demonstrated at last, which confirms the luminescent ZnO QDs@AMONIL reliable processing capabilities in wavelength-scale and envisions its promising applications in the optoelectronic micro-/nanodevices.ZnO quantum dot, nanoimprint lithography, photonic crystals, resist