The GUCY2C Tumor Suppressor is the Nexus of a Paracrine Hormone Axis Preventing Radiotherapy-Induced Gastrointestinal (GI) Toxicity

Purpose/Objective: Radiation-induced GI toxicity is the primary dose limitation compromising therapy in cancer patients treated with radiation therapy. GUCY2C is the intestinal receptor for diarrheagenic bacterial enterotoxins and the endogenous paracrine hormones guanylin and uroguanylin. Following genomic insult, cyclic (c)GMP produced by ligand activation of GUCY2C enhances DNA damage sensing and repair in intestinal cells. Here, we show that the GUCY2C-cGMP axis mediates p53-dependent radioprotection of intestinal epithelial cells. American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, C

Chart Rounds in the Digital Age: A Survey of North American Institutions

Purpose/Objective(s): In light of public concerns regarding the quality of radiation treatment delivery, we surveyed the utilization of “chart rounds” or peer-review quality assurance meetings, within North American academic institutions. American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, C

Search for non-strange exotic mesons produced via baryon exchange

Negative results on backward production via baryon exchange, of exotic non-strange mesons are presented. The reactions pi /sup -/p to p/sub forward/X/sup -/ and pi /sup -/n to p/sub forward/X/sup --/ have been studied with a 12 GeV/c pi /sup -/ beam in the Omega spectrometer at CERN. No resonant peak in X to pp pi /sup -/, pp pi /sup -/ pi /sup - /, pp pi /sup -/ pi /sup 0/, pi /sup +/ pi /sup -/ pi /sup -/ pi /sup -/, pi /sup +/ pi /sup -/ pi /sup -/ pi /sup 0/ has been seen. The upper limits obtained on cross sections for exotic meson production X to NN pi , NN pi pi , 4 pi are lower than the rho /sup -/ backward production cross section in the pi /sup -/p to p rho /sup -/ reaction; this result seems to contradict the predictions of the two-component duality model. Compared with already published experiments in the search for exotics produced via baryon exchange, the sensitivity of this experiment is higher by an order of magnitude. (20 refs)