A new cross-layer dynamic spectrum access architecture for TV White Space cognitive radio applications

As evermore applications and services are developed for wireless devices, the dramatic growth in user data traffic has led to the legacy channels becoming congested with the corresponding imperative of requiring more spectra. This has motivated both regulatory bodies and commercial companies to investigate strategies to increase the efficiency of the existing spectrum. With the emergence of cognitive radio technology, and the transference of TV channels from analogue to digital platforms, a unique opportunity to exploit spectrum by mobile digital service providers has emerged, commonly referred to as TV White Space (TVWS). One of the challenges in utilising TVWS spectrum is reliable primary user (PU) detection which is essential as any unlicensed secondary user has no knowledge of the PU and thereby can generate interference. This paper addresses the issue of PU detection by introducing a new dynamic spectrum access algorithm that exploits the unique properties of how digital TV (DTV) frequencies are deployed. A fuzzy logic inference model based on an enhanced detection algorithm (EDA) is used to resolve the inherent uncertain nature of DTV signals. Simulation results confirm EDA significantly improves the detection probability of a TVWS channel compared to existing PU detection techniques, while providing consistently low false positive detections. The paper also analyses the impact of the hidden node problem on EDA by modelling representative buildings and proposes a novel solution

Cognitive Radio and TV White Space (TVWS) Applications

As more user applications emerge for wireless devices, the corresponding amount of traffic is rapidly expanding, with the corollary that ever-greater spectrum capacity is required. Service providers are experiencing deployment blockages due to insufficient bandwidth being available to accommodate such devices. TV White Space (TVWS) represents an opportunity to supplement existing licensed spectrum by exploiting unlicensed resources. TVWS spectrum has materialised from the unused TV channels in the switchover from analogue to digital platforms. The main obstacles to TVWS adoption are reliable detection of primary users (PU) i.e., TV operators and consumers, allied with specifically, the hidden node problem. This chapter presents a new Generalised Enhanced Detection Algorithm (GEDA) that exploits the unique way Digital Terrestrial TV (DTT) channels are deployed in different geographical areas. GEDA effectively transforms an energy detector into a feature sensor to achieve significant improvements in detection probability of a DTT PU. Furthermore, by framing a novel margin strategy utilising a keep out contour, the hidden node issue is resolved, and a viable secondary user sensing solution formulated. Experimental results for a cognitive radio TVWS model have formalised both the bandwidth and throughput gains secured by TVWS users with this new paradigm

Chaos and localization in the wavefunctions of complex atoms NdI, PmI and SmI

Wavefunctions of complex lanthanide atoms NdI, PmI and SmI, obtained via multi-configuration Dirac-Fock method, are analyzed for density of states in terms of partial densities, strength functions ($F_k(E)$), number of principal components ($\xi_2(E)$) and occupancies (\lan n_\alpha \ran^E) of single particle orbits using embedded Gaussian orthogonal ensemble of one plus two-body random matrix ensembles [EGOE(1+2)]. It is seen that density of states are in general multi-modal, $F_k(E)$'s exhibit variations as function of the basis states energy and $\xi_2(E)$'s show structures arising from localized states. The sources of these departures from EGOE(1+2) are investigated by examining the partial densities, correlations between $F_k(E)$, $\xi_2(E)$ and \lan n_\alpha \ran^E and also by studying the structure of the Hamiltonian matrices. These studies point out the operation of EGOE(1+2) but at the same time suggest that weak admixing between well separated configurations should be incorporated into EGOE(1+2) for more quantitative description of chaos and localization in NdI, PmI and SmI.Comment: There are 9 figure

Schwinger Particle-Production Mechanism for a Finite-Length Flux Tube with Transverse Confinement

Previous results for the pair production probability in a strong electric field with a finite longitudinal separation are generalized to the case of a finite-length flux tube with transverse confinement. The threshold length of the flux tube, below which pair production cannot occur, increases as a result of transverse confinement.Comment: 12 pages (REVTeX

Regional variation in primary care improvement strategies and policy: case studies that consider qualitative contextual data for performance measurement in three Canadian provinces

This is the final version. Available on open access from BMJ Publishing Group via the DOI in this recordOBJECTIVE: To explore regional primary care improvement strategies that are potentially determinants of primary care performance. DESIGN: Multiple comparative embedded case study. SETTING: Three regions in Canada: Fraser East, British Columbia; Eastern Ontario Health Unit, Ontario; Central Zone, Nova Scotia. DATA SOURCES: (1) In-depth interviews with purposively selected key informants (eg, primary care decision-makers, physician leads, regulatory agencies) and focus groups with patients and clinicians (n=68 participants) and (2) published and grey literature (n=205 documents). OUTCOME MEASURES: Variations in spread and uptake of primary care improvement strategies across the three study regions. NVivo (V.11) was used to manage data and perform content analysis to identify categories within and across cases. The coding structure was developed by researchers through iterative collaboration, using inductive and deductive processes. RESULTS: Six overarching primary care improvement strategies, differing in focus and spread, were implemented across the three study regions: interprofessional team-based approaches, provider skill mix expansion, physician groups and networks, information systems, remuneration and performance measurement and reporting infrastructure. CONCLUSION: The addition of information on regional improvement strategies to primary care performance reports could add important contextual insights into primary care performance results. This could help identify possible drivers of reported performance outcomes and levers for change in practice, regional and system-level settings.Canadian Institutes of Health ResearchMichael Smith Foundation for Health Researc

Series Expansion Calculation of Persistence Exponents

We consider an arbitrary Gaussian Stationary Process X(T) with known correlator C(T), sampled at discrete times T_n = n \Delta T. The probability that (n+1) consecutive values of X have the same sign decays as P_n \sim \exp(-\theta_D T_n). We calculate the discrete persistence exponent \theta_D as a series expansion in the correlator C(\Delta T) up to 14th order, and extrapolate to \Delta T = 0 using constrained Pad\'e approximants to obtain the continuum persistence exponent \theta. For the diffusion equation our results are in exceptionally good agreement with recent numerical estimates.Comment: 5 pages; 5 page appendix containing series coefficient

Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys

Objective To assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals in Hong Kong and the effect of escalation in the World Health Organization’s alert level for an influenza pandemic

In vivo biocompatibility and immunogenicity of metal-phenolic gelation

In vivo forming hydrogels are of interest for diverse biomedical applications due to their ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled using metal–phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. TiIV or ZrIV) provide a versatile and robust platform for engineering such materials. However, the in situ formation and in vivo response to this new class of materials has not yet been reported. Here, we demonstrate that metal–phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. The TiIV–tannic acid materials form stable gels that are well-tolerated following subcutaneous injection. Histology reveals a mild foreign body reaction, and titanium biodistribution studies show low accumulation in distal tissues. Compared to poloxamer-based hydrogels (commonly used for in vivo gelation), TiIV–tannic acid materials show substantially improved in vitro drug loading and release profile for the corticosteroid dexamethasone (from 10 days). These results provide essential in vivo characterization for this new class of metal–phenolic hydrogels, and highlight their potential suitability for biomedical applications in areas such as drug delivery and regenerative medicine.<br

Effects of Parton Intrinsic Transverse Momentum on Photon Production in Hard-Scattering Processes

We calculate the photon production cross section arising from the hard scattering of partons in nucleon-nucleon collisions by taking into account the intrinsic parton transverse momentum distribution and the next-to-leading-order contributions. As first pointed out by Owens, the inclusion of the intrinsic transverse momentum distribution of partons leads to an enhancement of photon production cross section in the region of photon transverse momenta of a few GeV/c for nucleon-nucleon collisions at a center-of-mass energy of a few tens of GeV. The enhancement increases as $\sqrt{s}$ decreases. Such an enhancement is an important consideration in the region of photon momenta under investigation in high-energy heavy-ion collisions.Comment: 10 pages, 9 figures, in LaTex, revised to include ananlytic evaluation of the hard-scattering integra

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults

BACKGROUND: Studying cytokine/chemokine responses in severe influenza infections caused by different virus subtypes may improve understanding on pathogenesis. METHODS: Adults hospitalized for laboratory-confirmed seasonal and pandemic 2009 A/H1N1 (pH1N1) influenza were studied. Plasma concentrations of 13 cytokines/chemokines were measured at presentation and then serially, using cytometric-bead-array with flow-cytometry and ELISA. PBMCs from influenza patients were studied for cytokine/chemokine expression using ex-vivo culture (Whole Blood Assay,±PHA/LPS stimulation). Clinical variables were prospectively recorded and analyzed. RESULTS: 63 pH1N1 and 53 seasonal influenza patients were studied. pH1N1 patients were younger (mean±S.D. 42.8±19.2 vs 70.5±16.7 years), and fewer had comorbidities. Respiratory/cardiovascular complications were common in both groups (71.4% vs 81.1%), although severe pneumonia with hypoxemia (54.0% vs 28.3%) and ICU admissions (25.4% vs 1.9%) were more frequent with pH1N1. Hyperactivation of the proinflammatory cytokines IL-6, CXCL8/IL-8, CCL2/MCP-1 and sTNFR-1 was found in pH1N1 pneumonia (2-15 times normal) and in complicated seasonal influenza, but not in milder pH1N1 infections. The adaptive-immunity (Th1/Th17)-related CXCL10/IP-10, CXCL9/MIG and IL-17A however, were markedly suppressed in severe pH1N1 pneumonia (2-27 times lower than seasonal influenza; P-values<0.01). This pattern was further confirmed with serial measurements. Hypercytokinemia tended to be sustained in pH1N1 pneumonia, associated with a slower viral clearance [PCR-negativity: day 3-4, 55% vs 85%; day 6-7, 67% vs 100%]. Elevated proinflammatory cytokines, particularly IL-6, predicted ICU admission (adjusted OR 12.6, 95%CI 2.6-61.5, per log(10)unit increase; P = 0.002), and correlated with fever, tachypnoea, deoxygenation, and length-of-stay (Spearman's rho, P-values<0.01) in influenza infections. PBMCs in seasonal influenza patients were activated and expressed cytokines ex vivo (e.g. IL-6, CXCL8/IL-8, CCL2/MCP-1, CXCL10/IP-10, CXCL9/MIG); their 'responsiveness' to stimuli was shown to change dynamically during the illness course. CONCLUSIONS: A hyperactivated proinflammatory, but suppressed adaptive-immunity (Th1/Th17)-related cytokine response pattern was found in severe pH1N1 pneumonia, different from seasonal influenza. Cytokine/immune-dysregulation may be important in its pathogenesis