Serum metabolomics approach to monitor the changes in metabolite profiles following renal transplantation

Systemic metabolic changes after renal transplantation reflect the key processes that are related to graft accommodation. In order to describe and better understand these changes, the 1HNMR based metabolomics approach was used. The changes of 47 metabolites in the serum samples of 19 individuals were interpreted over time with respect to their levels prior to transplantation. Considering the specific repeated measures design of the experiments, data analysis was mainly focused on the multiple analyses of variance (ANOVA) methods such as ANOVA simultaneous component analysis and ANOVA-target projection. We also propose here the combined use of ANOVA and classification and regression trees (ANOVA-CART) under the assumption that a small set of metabolites the binary splits on which may better describe the graft accommodation processes over time. This assumption is very important for developing a medical protocol for evaluating a patient’s health state. The results showed that besides creatinine, which is routinely used to monitor renal activity, the changes in levels of hippurate, mannitol and alanine may be associated with the changes in renal function during the post-transplantation recovery period. Specifically, the level of hippurate (or histidine) is more sensitive to any short-term changes in renal activity than creatinine

Projekt koncepcyjny systemu antykolizyjnego dla pojazdów szynowych

This paper presents the concepts for an anti-collision system intended for trams. The purpose of the anti-collision system is to develop and provide information to support the driver’s decision to initiate the braking of a tram. The anti-collision system is based on the processing of data from multiple sources (obstacle detection, image processing, and visual light communication system) and an expert system. The information about the road situation is visually presented on HUD (Head-up Display) of the driver.W artykule przedstawiono koncepcje systemu antykolizyjnego przeznaczonego dla pojazdów szynowych. Zadaniem systemu jest wypracowanie informacji wspomagającej motorniczego w podjęciu decyzji o rozpoczęcie procesu hamowania. System opary jest na wykorzystaniu informacji z wielu źródeł (układu wykrywania przeszkód, układu rozpoznania obrazowego, układu komunikacji świetlnej) i na podstawie algorytmu zaimplementowanego w systemie eksperckim, zobrazowaniu informacji dla motorniczego na wyświetlaczu przeziernym