Gradient flow scale setting with tree-level improvement

Lattice scales defined using gradient flow are typically very precise, while also easy to calculate. However, different definitions of flows and operators can differ significantly, suggesting possible systematical effects. Using a subset of RBC-UKQCD's 2+1 flavor domain wall fermion and Iwasaki gauge action ensembles, we explore differences between $\sqrt{t_0}$ and $w_0$ gradient flow scales, compare the impact of different operators to define the energy density, and study the effect of using tree-level improvement for the gradient flow. We find that for this set of gauge field ensembles Zeuthen flow with Symanzik operators has the most consistent approach to the continuum limit and exhibit very small cutoff corrections. Tree-level improvement, traditionally used in step-scaling studies, significantly reduces the spread between different operators, but does not lead to an overall improvement when it comes to reducing cutoff effects for gradient flow scales $\sqrt{t_0}$ or $w_0$.Comment: 9 pages, 6 figures, contribution to the 39th International Symposium on Lattice Field Theory, August 8-13 2022, Bonn, German

Концепт «устойчивое развитие / sustainable development» в русскоязычном и англоязычном дискурсе сферы природопользования

Работа нацелена на выявление особенностей концепта "устойчивое развитие / sustainable development", объективированного в русскоязычном и англоязычном дискурсе сферы природопользования. Были выявлены и систематизированы единицы объективации рассматриваемого концепта, определены основные когнитивные признаки концепта "устойчивое развитие / sustainable development", формирующие его содержание и полевую структуру в русскоязычном и англоязычном дискурсе сферы природопользования. Набор выявленных когнитивных признаков концепта "устойчивое развитие / sustainable development" представлен в виде макроструктуры и полевой структуры, сделаны выводы об особенностях объективации исследуемого концепта в русскоязычном и англоязычном дискурсе сферы природопользования.The research aim is to identify peculiarities of the concept "устойчивое развитие / sustainable development", presented in the Russian-language and English-language discourse of natural management, which were identified and systematized units objectifying this concept, described the main cognitive features concept "устойчивое развитие / sustainable development", which build its content in the Russian-language and English-language discourse of natural management. The identified cognitive features of the concept "устойчивое развитие / sustainable development" are presented in form of its macrostructure and field organization. We also have made conclusions about peculiarities of objectification of this concept in the Russian- language and English-language discourse of natural management

Zafar, Capital of Himyar, Ibb Province, Yemen: First Preliminary Report: Summer 1998 and Autumn 2000, Second Preliminary Report: 2002, Third Preliminary Report: 2003, Fourth Preliminary Report: 2004

In 1998, the Heidelberg University Expedition to Zafar, in the Yemenite Highlands, initiated a programme of excavation, mapping and training. Zafar was the capital of the tribal confederation known to the outside world as Himyar, which for some 250 years dominated the entire Arabian Peninsula politically and militarily. The mapping showed the ancient walled city to be worthy of its name with a core area comprising some 1000 x 1200 m. The 2000 season concentrated on the excavation of a late Himyarite cemetery on a mountain slope called al-Asima/Salm. During the 2002 season, a foundation at the southern foot of the famous Husn Raydan was excavated, the site museum was newly installed and all of the inscriptions were photographed. In 2003, we photographed the entire collection of sculptures and began excavation on the south-western flank of the Husn Raydan in what appears to be magazines. Finally, in 2004 excavation was taken up in an area 10 m to the south, where a corner of a large limestone building came to light. Parts of the site were investigated by means of magnetometer survey. Until this time, experts described Zafar as utterly ruined and decadent in terms of its material culture. The foregoing contains the first preliminary report of the fieldwork in Zafar, a project which attempts to illuminate the latter part of the late pre-Islamic period

Using CAD in final quilifying works of bachelors

There are considered the possibility of using CAD in final qualifying works of bachelors. There are shown practical application of skills for future job of Graduates Automating the processes of heat and power. One of the graduate’s activities is design of functional, principle and wiring scheme. These types of schemes are included in the compulsory set of demonstration material. Quality of schemes speaks about professionalism of bachelors and gives potential employers opportunity to assess how professional designer. Students in the performance of graphics use different CAD systems such as AutoCAD, Microsoft Visio, Compas. Work designer and installer is impossible without knowledge some different CAD system. CAD systems are taught in several disciplines of the educational process

Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh—Study with long‐term follow‐up

Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who underwent pLT from 2011 to 2014, were analyzed, divided into definite abdominal wall closure with and without implantation of a BM. Primary end-point was the occurrence of postoperative abdominal wall infection. Secondary end-points included 1- and 5-year patient and graft survival and the development of abdominal wall hernia. In five out of 21 pLT recipients (23.8%), direct abdominal wall closure was achieved, whereas 16 recipients (76.2%) received a BM. BM removal was necessary in one patient (6.3%) due to abdominal wall infection, whereas no abdominal wall infection occurred in the no-BM group. No significant differences between the two groups were observed for 1- and 5-year patient and graft survival. Two late abdominal wall hernias were observed in the BM group vs none in the no-BM group. Definite abdominal wall closure with a BM after pLT is feasible and safe when direct closure cannot be achieved with comparable postoperative patient and graft survival rates

Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center

Background and purpose: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. Materials and methods: Patient recruitment numbers in prospective clinical studies of solid malignancies were retrospectively analyzed for the years 2019 – 2021 at the Comprehensive Cancer Center Zurich (CCCZ). Changes in recruitment numbers were tested for association with organ-specific subunits, as well as organizational and treatment-related trial characteristics. To assess differences between categorical variables, Chi-squared test was used. For uni- and multivariate analysis, Cox proportional hazards were calculated. Results: In 2019, there were a total of 107 studies (registry trials, clinical phase I-III trials, and translational studies) recruiting 304 patients at the CCCZ. During the COVID-19 pandemic in 2020 and 2021, there were 120 and 125 active trials with a total recruitment of 355 and 666 patients, respectively. No significant differences between the subunits and study characteristics in changes of patient recruitment in clinical phase I-III trials were identified when the year prior to the COVID-19 pandemic (2019) was compared to the first year of the pandemic (2020) and to 2020-2021. Conclusions: Despite healthcare systems around the world have experienced significant disruption due to the COVID-19 pandemic, data from our tertiary cancer center showed that clinical trial activities were maintained at a high level during the pandemic

Appbasierte Förderansätze für Kinder mit Lernstörungen

Hintergrund: Einstellungen zu digitalen Fördermaßnahmen wurden bislang hauptsächlich aus der Sicht von Lehrkräften untersucht, obwohl das Lernen mit digitalen Hilfsmitteln im häuslichen Umfeld an Bedeutung gewinnt. Deshalb wird der Frage nachgegangen, wie Angehörige/Eltern von Kindern mit Lernstörungen (= KmL: Rechenstörung, Lesestörung bzw. kombinierte Lernstörung) die Förderung mit Trainings-Apps via Tablet in der häuslichen Umgebung erleben und was für sie in diesem Kontext wichtig ist. Methoden: Mithilfe leitfadengestützter Expert_inneninterviews wurden 21 Angehörige von KmL und zwei Projektbegleiterinnen, die im regelmäßigen Austausch mit den Angehörigen standen, interviewt; zusätzlich wurden mit einem schriftlichen Fragebogen qualitative Datensätze zum Lernerleben mit den Apps sowie zur allgemeinen Wahrnehmung der Apps aus der Perspektive von 1) KmL (n = 83), welche die Trainings-App genutzt haben, und 2) weiteren Angehörigen (n = 81) erhoben. Ergebnis: Durch qualitative Analysen wurden Gelingensbedingungen (z.B. das Engagement der Angehörigen), aber auch Herausforderungen für die Verwendung von Trainings-Apps (z.B. technische Schwierigkeiten, Missverständnisse, Qualität der Stimmausgabe, als unpassend empfundener Schwierigkeitsgrad) herausgearbeitet. Diskussion: Aktuell wird das Training wahlweise als zu schwer, zu leicht oder zu ausufernd wahrgenommen. Um hier eine individuelle Passung zu erreichen, ist weitere Forschung sowie Entwicklung notwendig.Background: While learning with digital tools gains increasing importance, attitudes towards digital intervention tools have so far mainly been investigated from the perspective of teachers. Therefore, the question is investigated how relatives/parents of children with specific educational learning disorders (= CwLD: dyscalculia, reading disorder or combined learning disorder) experience the support with training apps via tablet in their home environment and what is important for them in this context. Methods: Using guideline-based expert interviews, 21 relatives of CwLD and two female employees, who worked as technical support and were in regular contact with the relatives, were interviewed; in addition, a questionnaire was used to collect qualitative data sets on the learning experience with the apps and on the general perceptions of the apps from the perspective of 1) the CwLD (n = 83) who used the training app and 2) other relatives (n = 81). Results: With qualitative analyses conditions for success (e.g., engagement of relatives) but also limitations to the use of training apps (e.g., technical difficulties, misunderstandings, voice output, perceived inappropriateness of training difficulty) were identified. Discussion: Currently, training is perceived as either too difficult, too easy, or too extensive. To achieve an individual fit, further research and development is necessary

Hepatic artery reconstruction using an operating microscope in pediatric liver transplantation—Is it worth the effort?

Introduction: In pediatric liver transplantation (pLT), hepatic artery thrombosis (HAT) is associated with inferior transplant outcome. Hepatic artery reconstruction (HAR) using an operating microscope (OM) is considered to reduce the incidence of HAT. Methods: HAR using an OM was compared to a historic cohort using surgical loupes (SL) in pLT performed between 2009 and 2020. Primary endpoint was the occurrence of HAT. Secondary endpoints were 1-year patient and graft survival determined by Kaplan-Meier analysis and complications. Multivariate analysis was used to identify independent risk factors for HAT and adverse events. Results: A total of 79 pLTs were performed [30 (38.0%) living donations; 49 (62.0%) postmortem donations] divided into 23 (29.1%) segment 2/3, 32 (40.5%) left lobe, 4 (5.1%) extended right lobe, and 20 (25.3%) full-size grafts. One-year patient and graft survival were both 95.2% in the OM group versus 86.2% and 77.8% in the SL group (p = .276 and p = .077). HAT rate was 0% in the OM group versus 24.1% in the SL group (p = .013). One-year patient and graft survival were 64.3% and 35.7% in patient with HAT, compared to 93.9% and 92.8% in patients with no HAT (both p < .001). Multivariate analysis revealed HAR with SL (p = .022) and deceased donor liver transplantation (DDLT) (p = .014) as independent risk factors for HAT. The occurrence of HAT was independently associated with the need for retransplantation (p < .001) and biliary leakage (p = .045). Conclusion: In pLT, the use of an OM is significantly associated to reduce HAT rate, biliary complications, and graft loss and outweighs the disadvantages of delayed arterial perfusion and prolonged warm ischemia time (WIT)

PRECYCLE: multicenter, randomized phase IV intergroup trial to evaluate the impact of eHealth-based patient-reported outcome (PRO) assessment on quality of life in patients with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer treated with palbociclib and an aromatase inhibitor or palbociclib and fulvestrant

Background Efficacy and quality of life (QoL) are key criteria for therapy selection in metastatic breast cancer (MBC). In hormone receptor positive (HR +) human epidermal growth factor receptor 2 negative (HER2 −) MBC, addition of targeted oral agents such as everolimus or a cycline-dependent kinase 4/6 (CDK 4/6) inhibitor (e.g., palbociclib, ribociclib, abemaciclib) to endocrine therapy substantially prolongs progression-free survival and in the case of a CDK 4/6i also overall survival. However, the prerequisite is adherence to therapy over the entire course of treatment. However, particularly with new oral drugs, adherence presents a challenge to disease management. In this context, factors influencing adherence include maintaining patients’ satisfaction and early detection/management of side effects. New strategies for continuous support of oncological patients are needed. An eHealth-based platform can help to support therapy management and physician–patient interaction. Methods PreCycle is a multicenter, randomized, phase IV trial in HR + HER2 − MBC. All patients (n = 960) receive the CDK 4/6 inhibitor palbociclib either in first (62.5%) or later line (37.5%) together with endocrine therapy (AI, fulvestrant) according to national guidelines. PreCycle evaluates and compares the time to deterioration (TTD) of QoL in patients supported by eHealth systems with substantially different functionality: CANKADO active vs. inform. CANKADO active is the fully functional CANKADO-based eHealth treatment support system. CANKADO inform is a CANKADO-based eHealth service with a personal login, documentation of daily drug intake, but no further functions. To evaluate QoL, the FACT-B questionnaire is completed at every visit. As little is known about relationships between behavior (e.g., adherence), genetic background, and drug efficacy, the trial includes both patient-reported outcome and biomarker screening for discovery of forecast models for adherence, symptoms, QoL, progression free survival (PFS), and overall survival (OS). Discussion The primary objective of PreCycle is to test the hypothesis of superiority for time to deterioration (TTD) in terms of DQoL = “Deterioration of quality of life” (FACT-G scale) in patients supported by an eHealth therapy management system (CANKADO active) versus in patients merely receiving eHealth-based information (CANKADO inform). EudraCT Number: 2016–004191-2