190 research outputs found
Water, Sanitation, and Hygiene (WASH): a critical component for sustainable soil-transmitted helminth and schistosomiasis control
Soil-transmitted helminths (STH) and
schistosomes are parasites that affect the
world’s poorest people, causing losses of
up to 39 million and 70 million disability
adjusted life years (DALYs) respectively. The World Health Organization
(WHO) is at the forefront of developing
policy for the control of STH and
schistosomiasis, advocating for chemotherapy
as the cornerstone of control, with the
objective of reducing infection-associated
morbidity. Global uptake of chemotherapy
with albendazole or mebendazole
for STH and praziquantel for schistosomiasis
has significantly increased and
remains the principal control strategy. It is
cost-effective and reduces STH and
schistosome infections in human hosts.SJC is funded by an Australian Postgraduate Award and a University of Queensland Advantage
Scholarship, ACAC is an Australian National Health and Medical Research Council (NHMRC) Career
Development Fellow (631619), RJSM is funded by a Post-doctoral Research Fellowship from the University
of Queensland (41795457), JSM is an Australian National Health and Medical Research Council Practitioner
Fellow, and DJG is an Australian Research Council (DECRA) Fellow. This work is funded by an NHMRC
Partnership project in collaboration with WaterAid Australia
Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae
[abridged] Background: The distribution of chemical species in an open system
at metastable equilibrium can be expressed as a function of environmental
variables which can include temperature, oxidation-reduction potential and
others. Calculations of metastable equilibrium for various model systems were
used to characterize chemical transformations among proteins and groups of
proteins found in different compartments of yeast cells.
Results: With increasing oxygen fugacity, the relative metastability fields
of model proteins for major subcellular compartments go as mitochondrion,
endoplasmic reticulum, cytoplasm, nucleus. In a metastable equilibrium setting
at relatively high oxygen fugacity, proteins making up actin are predominant,
but those constituting the microtubule occur with a low chemical activity. A
reaction sequence involving the microtubule and spindle pole proteins was
predicted by combining the known intercompartmental interactions with a
hypothetical program of oxygen fugacity changes in the local environment. In
further calculations, the most-abundant proteins within compartments generally
occur in relative abundances that only weakly correspond to a metastable
equilibrium distribution. However, physiological populations of proteins that
form complexes often show an overall positive or negative correlation with the
relative abundances of proteins in metastable assemblages.
Conclusions: This study explored the outlines of a thermodynamic description
of chemical transformations among interacting proteins in yeast cells. The
results suggest that these methods can be used to measure the degree of
departure of a natural biochemical process or population from a local minimum
in Gibbs energy.Comment: 32 pages, 7 figures; supporting information is available at
http://www.chnosz.net/yeas
Two approaches to the study of the origin of life.
This paper compares two approaches that attempt to explain the origin of life, or biogenesis. The more established approach is one based on chemical principles, whereas a new, yet not widely known approach begins from a physical perspective. According to the first approach, life would have begun with - often organic - compounds. After having developed to a certain level of complexity and mutual dependence within a non-compartmentalised organic soup, they would have assembled into a functioning cell. In contrast, the second, physical type of approach has life developing within tiny compartments from the beginning. It emphasises the importance of redox reactions between inorganic elements and compounds found on two sides of a compartmental boundary. Without this boundary, ÂżlifeÂż would not have begun, nor have been maintained; this boundary - and the complex cell membrane that evolved from it - forms the essence of life
Shannon Information Theory and Molecular Biology
The role and the contribution of Shannon Information Theory to the development of Molecular Biology has been the object of stimulating debates during the last thirty years. This seems to be connected with some semantic charms associated with the use of the word \u201cinformation\u201d in the biological context. Furthermore information itself, if viewed in a broader perspective, is far from being completely defined in a fashion that overcomes the technical level at which the classical Information Theory has been conceived. This review aims at building on the acknowledged contribution of Shannon Information Theory to Molecular Biology, so as to discover if it is only a technical tool to analyze DNA and proteinic sequences, or if it can rise, at least in perspective, to a higher role that exerts an influence on the construction of a suitable model for handling the genetic information in Molecular Biology
Movable genetic elements and antibiotic resistance in enterococci
The enterococci possess genetic elements able to move from one strain to another via conjugation. Certain enterococcal plasmids exhibit a broad host range among gram-positive bacteria, but only when matings are performed on solid surfaces. Other plasmids are more specific to enterococci, transfer efficiently in broth, and encode a response to recipient-produced sex phermones. Transmissible non-plasmid elements, the conjugative transposons, are widespread among the enterococci and determine their own fertility properties. Drug resistance, hemolysin, and bacteriocin determinants are commonly found on the various transmissible enterococcal elements. Examples of the different systems are discussed in this review.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47900/1/10096_2005_Article_BF01963632.pd
Encounters with tall sails and tall tales : Mi'kmaq society, 1500-1760
This thesis examines the history of the Mi'kmaq people inhabiting Kmitkinag (Nova Scotia) and Unimaki (Cape Breton Island) from before contact to 1760. While contact precipitated change in Mi'kmaq society, the process was gradual, the result of the particular historical circumstances in which interactions between the two societies evolved. In the late seventeenth century, the Mi'kmaq established an alliance with the French Crown, made possible by previous social and economic relationships between Mi'kmaq families and French traders, fishermen and settlers. As European settlement increased and imperial rivalry in North America intensified in the eighteenth century, tensions emerged in the alliance, revealing the cultural differences between the Mi'kmaq and France's subjects. The thesis demonstrates that economic and political factors were more important than national identity in influencing the texture of Mi'kmaq-European relations
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