1,446 research outputs found
MoMEMta, a modular toolkit for the Matrix Element Method at the LHC
The Matrix Element Method has proven to be a powerful method to optimally
exploit the information available in detector data. Its widespread use is
nevertheless impeded by its complexity and the associated computing time.
MoMEMta, a C++ software package to compute the integrals at the core of the
method, provides a versatile implementation of the Matrix Element Method to
both the theory and experiment communities. Its modular structure covers the
needs of experimental analysis workflows at the LHC without compromising ease
of use on simpler and smaller simulated samples used for phenomenological
studies. With respect to existing tools, MoMEMta improves on usability and
flexibility. In this paper, we present version 1.0 of MoMEMta, together with
examples illustrating the wide range of applications at the LHC accessible for
the first time with a single tool.Comment: 18 pages, 3 figures; post peer revie
Corticosteroid therapy is associated with a decrease in mortality in a multicenter cohort of mechanically ventilated COVID-19 patients
peer reviewedRetrospectively analyzing the data of a multicenter cohort,
we observed that mortality of patients with SARS-CoV-2 pneumoniatreated
with mechanical ventilation was as high as 45% and median
survival time was 82 days. In this series, the risk factors for mortality
included age, renal and circulatory dysfunction, lymphopenia and the
absence of corticosteroid use during the first week of mechanical ventilation.
Corticosteroid therapy during the first week of mechanical ventilation
was associated with a lower mortality (34% vs 48%) (p = 0,01)
NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-ÎşB by Human T-Lymphotropic Virus Type 1 Tax Protein
Nuclear factor (NF)-ÎşB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-ÎşB occurs predominantly in the cytoplasm, where Tax1 binds NF-ÎşB Essential Modulator (NEMO/IKKÎł) and triggers the activation of IÎşB kinases. Several independent studies have shown that Tax1-mediated NF-ÎşB activation is dependent on Tax1 ubiquitination. Here, we identify by co-immunoprecipitation assays NEMO-Related Protein (NRP/Optineurin) as a binding partner for Tax1 in HTLV-1 infected and Tax1/NRP co-expressing cells. Immunofluorescence studies reveal that Tax1, NRP and NEMO colocalize in Golgi-associated structures. The interaction between Tax1 and NRP requires the ubiquitin-binding activity of NRP and the ubiquitination sites of Tax1. In addition, we observe that NRP increases the ubiquitination of Tax1 along with Tax1-dependent NF-ÎşB signaling. Surprisingly, we find that in addition to Tax1, NRP interacts cooperatively with the Tax1 binding protein TAX1BP1, and that NRP and TAX1BP1 cooperate to modulate Tax1 ubiquitination and NF-ÎşB activation. Our data strongly suggest for the first time that NRP is a critical adaptor that regulates the assembly of TAX1BP1 and post-translationally modified forms of Tax1, leading to sustained NF-ÎşB activation
Corticosteroids are associated with a decrease in mortality in a multicenter cohort of mechanically ventilated COVID-19 patients.
Measurement of differential cross sections for top quark pair production using the lepton plus jets final state in proton-proton collisions at 13 TeV
National Science Foundation (U.S.
Particle-flow reconstruction and global event description with the CMS detector
The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic tau decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8 TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions
Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV
Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)
Search for heavy resonances decaying to a top quark and a bottom quark in the lepton+jets final state in proton–proton collisions at 13 TeV
info:eu-repo/semantics/publishe
Evidence for the Higgs boson decay to a bottom quark–antiquark pair
info:eu-repo/semantics/publishe
Pseudorapidity and transverse momentum dependence of flow harmonics in pPb and PbPb collisions
info:eu-repo/semantics/publishe
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