744 research outputs found

    Spatial Reveries

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    We live in a hazy existence marked by rapid pace, development, digital consumption, and a deteriorating environment. Spatial Reveries hopes to counter the current trajectory and offer an alternative perspective by presenting one with moments of awe, discovery, and wonder to improve the disconnect between society and their surroundings. The work refers to a history of anamorphic art, cubism, deception, and optical phenomena in Western society. It operates on the urges and instincts of the artist, utilizing massing, light, transparency, horizons, and vastness, to challenge perceptions of space, time, and memory. Through the play of perspective and projection the work hopes to engage the individual’s body, mind, and eye ultimately creating a sense of presence and place within the larger cosmos. These somewhat obscure and opportunistic operations meditate on an architect’s vision of the world, the spatial opportunities it holds, and indirectly elicit thoughts surrounding nostalgia, consumption, the environment, and perspective

    Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study

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    Sims KB, Pastores GM, Weinreb NJ, Barranger J, Rosenbloom BE, Packman S, Kaplan P, Mankin H, Xavier R, Angell J, Fitzpatrick MA, Rosenthal D. Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study. Clin Genet 2008: 73: 430–440. © Blackwell Munksgaard, 200

    Assessing Dam Impacts on Stream Macroinvertebrate Community Structure.

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    The purpose of this experiment was to assess the impact of Kreis Dam on the macroinvertebrate community structure of Sharon Creek in Sharonville, Ohio. Three testing sites for sample collection with a steam reach of 35-50 meters each were selected based on the presence of riffles: upstream of the dam (US), downstream nearest to the dam (DS1), and downstream furthest from the dam (DS2). At each site, five kick samples were collected from riffles using a Surber sample, 500-micron D-framed net and sieve, and scrub brush. One composite sample was collected at each site with fifteen minutes to pick macroinvertebrates from various habitat types (riffles, runs, pools, and margins). The collected macroinvertebrates were identified to the family taxonomic level using a dichotomous key. Data metrics performed included density, %EPT, and Hilsenhoff Family-Level Biotic Index from each sample, with statistical significance determined by ANOVA and Tukey tests. Mean total riffle macroinvertebrate density upstream was significantly greater compared to the two downstream sites (US and DS1 (Tukey: p\u3c0.01); US and DS2 (Tukey: p\u3c 0.01)). Neither downstream site was statistically significantly different from the other. While there is no significant difference between sites for %EPT (ANOVA: F=0.92, df=2,12, p\u3c0.42), the overall trend in the data suggests that the %EPT is highest at the upstream site, lower at the site closest to the dam, then lowest at the site furthest from the dam, thus decreasing moving from upstream to downstream. A significant difference in Hilsenhoff scores between the upstream and downstream sites was observed (US and DS1 (Tukey: p\u3c0.05); US and DS2 (Tukey: p\u3c0.05)), but no statistically significant difference between the two downstream sites, with US scoring ‘fairly poor,’ DS1 ‘good,’ and DS2 ‘very good.

    An HLA Class II Region Restriction Fragment Length Polymorphism (RFLP) in Patients with Dermatitis Herpetiformis: Association with HLA-DP Phenotype

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    Dermatitis herpetiformis (DH) is characterized in part by an associated gluten-sensitive enteropathy (GSE), and a strong association with the HLA antigens HLA-A1, -B8, -DR3, and -DQw2, essentially identical to that seen in patients with isolated GSE (celiac disease). A 4.0-kb RsaI RFLP has been identified using a DQ β-chain cDNA and localized to the HLA-DP β-chain region. This RFLP has been found more frequently in patients with isolated GSE than in normal HLA matched controls. We have analyzed genomic DNA from 24 patients with DH and 15 HLA-matched controls to determine if this 4.0-kb RsaI RFLP was present in patients with DH. Twenty-one of 24 (87%) of patients with DH were found to have this RFLP as compared to 7 of 10 (70%) HLA-DR3, -DQw2 matched control subjects (p = 0.23). Thus, the 4.0-kb RsaI RFLP detected in patients with isolated GSE is also present in patients with DH; however, its frequency in DH patients does not differ significantly from that of HLA matched controls. Family studies of patients with DH revealed that although the 4.0-kb RsaI RFLP segregated with the HLA-A1, -B8, -DR3, -DQw2 haplotype in one family, it did not segregate with this disease-associated haplotype in two other families. In both patient and control populations, this RFLP was associated with HLA-DPw1 or -DPw3 phenotypes; 25 of 26 (96%) HLA-DPw1 or -DPw3 subjects were found to have this RFLP compared to only 1 of 6 (17%) who did not express HLA-DPw1 or -DPw3 (pc = 0.0009). These population and family data suggest that this 4.0-kb RsaI RFLP is primarily associated with the HLA- DPw1, -DPw3 phenotype, rather than the clinical manifestations of DH. These data further document that the strongest association of DH with HLA antigens remains with HLA-DQw2 and FILA-DR3 antigens

    General Strategies for Isolating the Genes Encoding Type I Collagen and for Characterizing Mutations Which Produce Osteogenesis Imperfecta a

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73326/1/j.1749-6632.1988.tb55325.x.pd

    PROGRAM ODD--A ONE-DIMENSIONAL MULTIGROUP CODE FOR THE IBM-7090 (ANP PROGRAM NO. 657)

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    The physical and mathematical reactor models which are used in Program ODD are discussed. In addition, the FORTRAN II source program listings, decimal data input sheets, and input and output for a sample case are given. Program ODD was designed to raake use of the Revised Nuclear Data System at ANPD which consists of twenty-five energy group cross-section data including high energy inelastic scattering matrices, resonance parameters for the resolved resonances, and thermalization scattering matrices for the near thermal energy region. The most unique aspect of the program is the mathematical technique employed for eliminating inner iterations and slow convergenc rates occasioned by the up- scattering'' in the thermalization region of the energy lattice. Direct inversion of the energy matrix coupling the thermal and last four epitherma groups provides simultaneous consistent solutions for thes groups within each power iteration. (auth

    Osteogenesis Imperfecta: The Molecular Basis of Clinical Heterogeneity a

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73685/1/j.1749-6632.1988.tb55324.x.pd
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