Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank

Objective—Elevated white blood cell count is associated with a higher risk of cardiovascular disease (CVD). We aimed to investigate whether specific leukocyte subpopulations, which may more closely indicate a specific inflammatory pathway, are specifically associated with CVD. Approach and Results—Participants (478 259) from UK Biobank with data for white blood cell count were included. Death because of CVD (n=1377) and non-CVD causes (n=8987) occurred during median follow-up time of 7.0 years (interquartile range, 6.3–7.6). In Cox models, deciles of leukocyte counts (lymphocytes, monocytes, neutrophils, eosinophils, and basophils) were examined using the fifth decile as the referent group. Models were stratified by sex and adjusted for a range of classical risk factors. A sensitivity analysis excluded participants with baseline comorbidites and the first 2 years of follow-up. Men (hazard ratio [HR], 1.59; 95% confidence interval, 1.22–2.08) and women (HR, 2.15; 95% confidence interval, 1.38–3.35) in the highest decile of neutrophil count were at higher risk of CVD mortality and nonfatal CVD (men HR, 1.28; 95% confidence interval, 1.16–1.42 and women HR, 1.21; 95% confidence interval, 1.06–1.38). In the sensitivity analysis, the power to investigate CVD mortality was limited, but for both sexes combined, the linear HRs for a 1×109/L cell count increase in white blood cell count and neutrophils, respectively, was 1.05 (1.03–1.07) and 1.07 (1.04–1.11). Conclusions—Among circulating leukocyte subpopulations, neutrophil count in men was most consistently associated with fatal and nonfatal CVD. Further studies of interventions that lower circulating neutrophils, such as canakinumab, are required to investigate causality

Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease

Chronic kidney disease is common in the general population and associated with excess cardiovascular disease (CVD), but kidney function does not feature in current CVD risk-prediction models. We tested three formulae for estimated glomerular filtration rate (eGFR) to determine which was the most clinically informative for predicting CVD and mortality. Using data from 440,526 participants from UK Biobank, eGFR was calculated using serum creatinine, cystatin C (eGFRcys) and creatinine-cystatin C. Associations of each eGFR with CVD outcome and mortality were compared using Cox models and adjusting for atherosclerotic risk factors (per relevant risk scores), and the predictive utility was determined by the C-statistic and categorical net reclassification index. We show that eGFRcys is most strongly associated with CVD and mortality, and, along with albuminuria, adds predictive discrimination to current CVD risk scores, whilst traditional creatinine-based measures are weakly associated with risk. Clinicians should consider measuring eGFRcys as part of cardiovascular risk assessment

The Star Formation Rate Function of the Local Universe

We have derived the bivariate luminosity function for the far ultraviolet (1530Angstroms) and far infrared (60 microns). We used matched GALEX and IRAS data, and redshifts from NED and PSC-z. We have derived a total star formation luminosity function phi(L_{tot}), with L_{tot} = L_{FUV}+L_{FIR}. Using these, we determined the cosmic ``star formation rate'' function and density for the local universe. The total SFR function is fit very well by a log-normal distribution over five decades of luminosity. We find that the bivariate luminosity function phi(L_{FUV},L_{FIR}) shows a bimodal behavior, with L_{FIR} tracking L_{FUV} for L_{TOT}< 10^10 L_sun, and L_{FUV} saturating at 10^10 L_sun, while L_{TOT} L_{FIR} for higher luminosities. We also calculate the SFR density and compare it to other measurements.Comment: This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200

The UV-Optical Galaxy Color-Magnitude Diagram. I. Basic Properties

We have analyzed the bivariate distribution of galaxies as a function of ultraviolet-optical colors and absolute magnitudes in the local universe. The sample consists of galaxies with redshifts and optical photometry from the Sloan Digital Sky Survey (SDSS) main galaxy sample matched with detections in the near-ultraviolet (NUV) and far-ultraviolet (FUV) bands in the Medium Imaging Survey being carried out by the Galaxy Evolution Explorer (GALEX) satellite. In the (NUV − r)_(0.1) versus M_(r,0.1) galaxy color-magnitude diagram, the galaxies separate into two well-defined blue and red sequences. The (NUV − r)_(0.1) color distribution at each M_(r,0.1) is not well fit by the sum of two Gaussians due to an excess of galaxies in between the two sequences. The peaks of both sequences become redder with increasing luminosity, with a distinct blue peak visible up to M_(r,0.1) ~ − 23. The r_(0.1)-band luminosity functions vary systematically with color, with the faint-end slope and characteristic luminosity gradually increasing with color. After correcting for attenuation due to dust, we find that approximately one-quarter of the color variation along the blue sequence is due to dust, with the remainder due to star formation history and metallicity. Finally, we present the distribution of galaxies as a function of specific star formation rate and stellar mass. The specific star formation rates imply that galaxies along the blue sequence progress from low-mass galaxies with star formation rates that increase somewhat with time to more massive galaxies with a more or less constant star formation rate. Above a stellar mass of ~10^(10.5) M_☉, galaxies with low ratios of current to past averaged star formation rate begin to dominate

The Calibration and Data Products of the Galaxy Evolution Explorer

We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the Far Ultraviolet (FUV, ~154 nm) and Near Ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon counting, microchannel plate, delay line readout detectors. These 1.25 degree field-of-view detectors are well-suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 mAB in the FUV and NUV, respectively. We have detected a long term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" RMS in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.Comment: Accepted to the ApJS (a special GALEX issue

Ly alpha-emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

We have used the GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of similar to 8 angstrom in the far-ultraviolet (FUV; 1350-1750 angstrom) and similar to 20 angstrom in the near-ultraviolet (NUV; 1950-2750 angstrom) for a systematic search of Ly alpha-emitting galaxies at low redshift. Our aim is to fill a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in five deep exposures (5.65 deg(2)) has resulted in 96 Ly alpha-emitting galaxy candidates in the FUV domain after accounting for broad-line AGNs. The Ly alpha equivalent widths (EWs) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, with the exception of a possible decrease in the most luminous objects that may be due to small-number statistics. The objects' distribution in EW is similar to that at z similar to 3, but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a subsample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly alpha luminosity function (LF). The incompleteness due to objects with significant Ly alpha emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H alpha LFs in the same redshift domain is consistent with an average Ly alpha/H alpha of similar to 1 in about 15% of the star-forming galaxies. A comparison with high-redshift Ly alpha LFs implies an increase of the Ly alpha luminosity density by a factor of about 16 from z similar to 0.3 to z similar to 3. By comparison with the factor of 5 increase in the UV luminosity density in the same redshift range, this suggests an increase of the average Ly alpha escape fraction with redshift

UV emission and Star Formation in Stephan's Quintet

we present the first GALEX UV images of the well known interacting group of galaxies, Stephan's Quintet (SQ). We detect widespread UV emission throughout the group. However, there is no consistent coincidence between UV structure and emission in the optical, H\alpha, or HI. Excluding the foreground galaxy NGC7320 (Sd), most of the UV emission is found in regions associated with the two spiral members of the group, NGC7319 and NGC7318b, and the intragroup medium starburst SQ-A. The extinction corrected UV data are analyzed to investigate the overall star formation activity in SQ. It is found that the total star formation rate (SFR) of SQ is 6.69+-0.65 M_\sun/yr. Among this, 1.34+-0.16 M_sun/yr is due to SQ-A. This is in excellent agreement with that derived from extinction corrected H\alpha luminosity of SQ-A. The SFR in regions related to NGC 7319 is 1.98+-0.58 M_\sun/yr, most of which(68%) is contributed by the disk. The contribution from the 'young tail' is only 15%. In the UV, the 'young tail' is more extended (~100 kpc) and shows a loop-like structure, including the optical tail, the extragalactic HII regions recently discovered in H\alpha, and other UV emission regions discovered for the first time. The UV and optical colors of the 'old tail' are consistent with a single stellar population of age t ~10^{8.5+-0.4} yrs. The UV emission associated with NGC 7318b is found in a very large (~80 kpc) disk, with a net SFR of 3.37+-0.25 M_sun/yr. Several large UV emission regions are 30 -- 40 kpc away from the nucleus of NGC7318b. Although both NGC7319 and NGC7318b show peculiar UV morphology, their SFR is consistent with that of normal Sbc galaxies, indicating that the strength of star formation activity is not enhenced by interactions.Comment: This paper will be published as part of the Galaxy Evolution Explorer(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200

Lyman alpha emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

The GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of about 8 A in the FUV (1350 - 1750 A) and about 20 A in the NUV (1950 - 2750 A) is used for a systematic search of Ly-a emitting galaxies at low redshift. This aims at filling a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in 5 deep exposures (5.65 sq.deg) has resulted in 96 Ly-a emitting galaxy candidates in the FUV domain, after accounting for broad-line AGNs. The Ly-a EWs (equivalent width) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, except a possible decrease in the most luminous that may be due to small-number statistics. Their distribution in EW is similar to that at z about 3 but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a sub-sample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly-a LF (luminosity function). The incompleteness due to objects with significant Ly-a emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H-a LF in the same redshift domain is consistent with an average Ly-a/H-a of about 1 in about 15 % of the star-forming galaxies. A comparison with high-redshift Ly-a LFs implies an increase of the Ly-a luminosity density by a factor of about 16 from z about 0.3 to z about 3. By comparison with the factor 5 increase of the UV luminosity density in the same redshift range, this suggests an increase of the average Ly-a escape fraction with redshift.Comment: 18 pages, 9 figures, accepted for publication in Ap