A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy

Peer reviewedPostprin

The CLIC Programme: Towards a Staged e+e- Linear Collider Exploring the Terascale : CLIC Conceptual Design Report

This report describes the exploration of fundamental questions in particle physics at the energy frontier with a future TeV-scale e+e- linear collider based on the Compact Linear Collider (CLIC) two-beam acceleration technology. A high-luminosity high-energy e+e- collider allows for the exploration of Standard Model physics, such as precise measurements of the Higgs, top and gauge sectors, as well as for a multitude of searches for New Physics, either through direct discovery or indirectly, via high-precision observables. Given the current state of knowledge, following the observation of a 125 GeV Higgs-like particle at the LHC, and pending further LHC results at 8 TeV and 14 TeV, a linear e+e- collider built and operated in centre-of-mass energy stages from a few-hundred GeV up to a few TeV will be an ideal physics exploration tool, complementing the LHC. In this document, an overview of the physics potential of CLIC is given. Two example scenarios are presented for a CLIC accelerator built in three main stages of 500 GeV, 1.4 (1.5) TeV, and 3 TeV, together with operating schemes that will make full use of the machine capacity to explore the physics. The accelerator design, construction, and performance are presented, as well as the layout and performance of the experiments. The proposed staging example is accompanied by cost estimates of the accelerator and detectors and by estimates of operating parameters, such as power consumption. The resulting physics potential and measurement precisions are illustrated through detector simulations under realistic beam conditions.Comment: 84 pages, published as CERN Yellow Report https://cdsweb.cern.ch/record/147522

Identification of single-site gold catalysis in acetylene hydrochlorination

There remains considerable debate over the active form of gold under operating conditions of a recently validated gold catalyst for acetylene hydrochlorination. We have performed an in situ x-ray absorption fine structure study of gold/carbon (Au/C) catalysts under acetylene hydrochlorination reaction conditions and show that highly active catalysts comprise single-site cationic Au entities whose activity correlates with the ratio of Au(I):Au(III) present. We demonstrate that these Au/C catalysts are supported analogs of single-site homogeneous Au catalysts and propose a mechanism, supported by computational modeling, based on a redox couple of Au(I)-Au(III) species. View Full Tex

Disentangling Electron-Boson Interactions on the Surface of a Familiar Ferromagnet

We report energy renormalizations from electron-phonon and electron-magnon interactions in spin minority surface resonances on Ni(111). The different interactions are disentangled and quantified in strength $\lambda$, based on the characteristic shapes of their complex self-energies, and the largely different binding energies at which they occur. The observed electron-magnon interactions reveal a strong dependence on momentum and energy band position in the bulk Brillouin zone. In contrast, electron-phonon interactions from the same bands are observed to be practically momentum- and symmetry-independent. Additionally, a moderately strong ($\lambda>0.5$) electron-phonon interaction is observed from a `buried', near-parabolic spin majority band that does not cross the Fermi level.Comment: QuSpin 202

Towards a quality-controlled and accessible Pitzer model for seawater and related systems

We elaborate the need for a quality-controlled chemical speciation model for seawater and related natural waters, work which forms the major focus of SCOR Working Group 145. Model development is based on Pitzer equations for the seawater electrolyte and trace components. These equations can be used to calculate activities of dissolved ions and molecules and, in combination with thermodynamic equilibrium constants, chemical speciation. The major tasks to be addressed are ensuring internal consistency of the Pitzer model parameters (expressing the interactions between pairs and triplets of species, which ultimately determines the calculated activities), assessing uncertainties, and identifying important data gaps that should be addressed by new measurements. It is recognised that natural organic matter plays an important role in many aquatic ecosystems, and options for including this material in a Pitzer-based model are discussed. The process of model development begins with the core components which include the seawater electrolyte and the weak acids controlling pH. This core model can then be expanded by incorporating additional chemical components, changing the standard seawater composition and/or broadening the range of temperature and pressure, without compromising its validity. Seven important areas of application are identified: open ocean acidification; micro-nutrient biogeochemistry and geochemical tracers; micro-nutrient behaviour in laboratory studies; water quality in coastal and estuarine waters; cycling of nutrients and trace metals in pore waters; chemical equilibria in hydrothermal systems; brines and salt lakes

High-Throughput Analysis of Optical Mapping Data Using ElectroMap

Optical mapping is an established technique for high spatio-temporal resolution study of cardiac electrophysiology in multi-cellular preparations. Here we present, in a step-by-step guide, the use of ElectroMap for analysis, quantification, and mapping of high-resolution voltage and calcium datasets acquired by optical mapping. ElectroMap analysis options cover a wide variety of key electrophysiological parameters, and the graphical user interface allows straightforward modification of pre-processing and parameter definitions, making ElectroMap applicable to a wide range of experimental models. We show how built-in pacing frequency detection and signal segmentation allows high-throughput analysis of entire experimental recordings, acute responses, and single beat-to-beat variability. Additionally, ElectroMap incorporates automated multi-beat averaging to improve signal quality of noisy datasets, and here we demonstrate how this feature can help elucidate lectrophysiological changes that might otherwise go undetected when using single beat analysis. Custom modules are included within the software for detailed investigation of conduction, single file analysis, and alternans, as demonstrated here. This software platform can be used to enable and accelerate the processing, analysis, and mapping of complex cardiac electrophysiology

Holes in the t-J_z model: a thorough study

The t-J_z model is the strongly anisotropic limit of the t-J model which captures some general properties of the doped antiferromagnets (AF). The absence of spin fluctuations simplifies the analytical treatment of hole motion in an AF background and allows us to calculate the single- and two-hole spectra with high accuracy using regular diagram technique combined with real-space approach. At the same time, numerical studies of this model via exact diagonalization (ED) on small clusters show negligible finite size effects for a number of quantities, thus allowing a direct comparison between analytical and numerical results. Both approaches demonstrate that the holes have tendency to pair in the p- and d-wave channels at realistic values of t/J. The interactions leading to pairing and effects selecting p and d waves are thoroughly investigated. The role of transverse spin fluctuations is considered using perturbation theory. Based on the results of the present study, we discuss the pairing problem in the realistic t-J-like model. Possible implications for preformed pairs formation and phase separation are drawn.Comment: 21 pages, 15 figure

A time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo

Imaging the spatio-temporal interaction of proteins in vivo is essential to understanding the complexities of biological systems. The highest accuracy monitoring of protein-protein interactions is achieved using FRET measured by fluorescence lifetime imaging with measurements taking minutes to acquire a single frame, limiting their use in dynamic live cell systems. We present a diffraction limited, massively parallel, time-resolved multifocal multiphoton microscope capable of producing fluorescence lifetime images with 55 ps time-resolution giving improvements in acquisition speed of a factor of 64. We present demonstrations with FRET imaging in a model cell system and demonstrate in vivo FLIM using a GTPase biosensor in the zebrafish embryo