19 research outputs found
In-depth genetic analysis of Clostridium difficile PCR-ribotype 027 strains reveals high genome fluidity including point mutations and inversions
No full textPreviously, we demonstrated that the recently evolved PCR-ribotype 027 hypervirulent Clostridium difficile strain (R20291) has acquired five genetic regions compared to the historic 027 counterpart strain (CD196), that may in part explain phenotypic traits relating to survival, antimicrobial resistance and virulence. Closer scrutiny of the three genome sequences reveals that, in addition to gene gain/loss, point mutations and inversions appear to have accumulated. Inversions are located upstream of potential coding sequences and could affect expression of these. C. difficile has a highly fluid genome with multiple mechanisms to modify its genetic content and is continuing to evolve in our hospitals influenced by environmental changes and human activity
Artemis and ligase 4 are dispensable for the generation of human induced pluripotent stem cells
No full textThe role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies.
No full textThe role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies
No full textDifferential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.
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Differential Role for Dna Ligase 4, Artemis and Dna-Pkcs in the Generation, Dna Damage Response and Myeloid Differentiation of Human Ips Cells
No full textJakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (<em>STAT1</em>) or <em>STAT3</em> mutations
No full textThe Extracytoplasmic Function Sigma Factor EcfO Protects Bacteroides fragilis against Oxidative Stress
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