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Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.
Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an antigen expressed on a distinct subpopulation of T cells that respond to class II major histocompatibility antigens. Treatment with anti-L3T4 depleted circulating target cells, reduced autoantibody production, retarded renal disease, and prolonged life relative to control mice treated either with saline or with purified nonimmune rat IgG. These findings establish that autoimmune disease in NZB/NZW mice is regulated by T cells. In contrast to mice treated with nonimmune rat IgG, mice treated with rat anti-L3T4 mAb developed little or no antibody to rat Ig. Thus, the benefits of treatment with anti-L3T4 were achieved while minimizing the risks associated with a host immune response to therapy. This study raises the possibility that treatment with mAb against Leu-3/T4, the human homologue for L3T4 might be effective in the treatment of certain autoimmune diseases in people
Exactly solvable model of dissipative vortex tunneling
I consider the problem of vortex tunneling in a two-dimensional
superconductor. The vortex dynamics is governed by the Magnus force and the
Ohmic friction force. Under-barrier motion in the vicinity of the saddle point
of the pinning potential leads to a model with quadratic Hamiltonian which can
be analytically diagonalized. I find the dependence of the tunneling
probability on the normal state quasiparticle relaxation time with a
minimum at , where is the level spacing of the
quasiparticle bound states inside the vortex core. The results agree
qualitatively with the available experimental data.Comment: RevTeX, 6 pages, 2 figures. Published versio
On Exactly Solvable Potentials
We investigate two methods of obtaining exactly solvable potentials with
analytic forms.Comment: 13 pages, Latex, to appear in Chineses Journal of Physic
Exceptional hyperbolic 3-manifolds
We correct and complete a conjecture of D. Gabai, R. Meyerhoff and N.
Thurston on the classification and properties of thin tubed closed hyperbolic
3-manifolds. We additionally show that if N is a closed hyperbolic 3-manifold,
then either N=Vol3 or N contains a closed geodesic that is the core of an
embedded tube of radius log(3)/2.Comment: 22 pages, 2 figure
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Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction.
When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt-2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR
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