651 research outputs found
On-Line AdaTron Learning of Unlearnable Rules
We study the on-line AdaTron learning of linearly non-separable rules by a
simple perceptron. Training examples are provided by a perceptron with a
non-monotonic transfer function which reduces to the usual monotonic relation
in a certain limit. We find that, although the on-line AdaTron learning is a
powerful algorithm for the learnable rule, it does not give the best possible
generalization error for unlearnable problems. Optimization of the learning
rate is shown to greatly improve the performance of the AdaTron algorithm,
leading to the best possible generalization error for a wide range of the
parameter which controls the shape of the transfer function.)Comment: RevTeX 17 pages, 8 figures, to appear in Phys.Rev.
Thermodynamic properties of extremely diluted symmetric Q-Ising neural networks
Using the replica-symmetric mean-field theory approach the thermodynamic and
retrieval properties of extremely diluted {\it symmetric} -Ising neural
networks are studied. In particular, capacity-gain parameter and
capacity-temperature phase diagrams are derived for and .
The zero-temperature results are compared with those obtained from a study of
the dynamics of the model. Furthermore, the de Almeida-Thouless line is
determined. Where appropriate, the difference with other -Ising
architectures is outlined.Comment: 16 pages Latex including 6 eps-figures. Corrections, also in most of
the figures have been mad
The Little-Hopfield model on a Random Graph
We study the Hopfield model on a random graph in scaling regimes where the
average number of connections per neuron is a finite number and where the spin
dynamics is governed by a synchronous execution of the microscopic update rule
(Little-Hopfield model).We solve this model within replica symmetry and by
using bifurcation analysis we prove that the spin-glass/paramagnetic and the
retrieval/paramagnetictransition lines of our phase diagram are identical to
those of sequential dynamics.The first-order retrieval/spin-glass transition
line follows by direct evaluation of our observables using population dynamics.
Within the accuracy of numerical precision and for sufficiently small values of
the connectivity parameter we find that this line coincides with the
corresponding sequential one. Comparison with simulation experiments shows
excellent agreement.Comment: 14 pages, 4 figure
Carbon fixation genes in biomining microorganisms
Background and aims: Studying metabolic pathways will help provide a better understanding of the role of different microorganisms within biomining environments. The majority of microorganisms involved in biomining are autotrophs which rely on atmospheric carbon fixation for growth. The aim of this study is to investigate genes involved with carbon fixation in a range of biomining microorganisms
Statistical Mechanics of Learning in the Presence of Outliers
Using methods of statistical mechanics, we analyse the effect of outliers on
the supervised learning of a classification problem. The learning strategy aims
at selecting informative examples and discarding outliers. We compare two
algorithms which perform the selection either in a soft or a hard way. When the
fraction of outliers grows large, the estimation errors undergo a first order
phase transition.Comment: 24 pages, 7 figures (minor extensions added
On the conditions for the existence of Perfect Learning and power law in learning from stochastic examples by Ising perceptrons
In a previous letter, we studied learning from stochastic examples by
perceptrons with Ising weights in the framework of statistical mechanics. Under
the one-step replica symmetry breaking ansatz, the behaviours of learning
curves were classified according to some local property of the rules by which
examples were drawn. Further, the conditions for the existence of the Perfect
Learning together with other behaviors of the learning curves were given. In
this paper, we give the detailed derivation about these results and further
argument about the Perfect Learning together with extensive numerical
calculations.Comment: 28 pages, 43 figures. Submitted to J. Phys.
Statistical Mechanics of Support Vector Networks
Using methods of Statistical Physics, we investigate the generalization
performance of support vector machines (SVMs), which have been recently
introduced as a general alternative to neural networks. For nonlinear
classification rules, the generalization error saturates on a plateau, when the
number of examples is too small to properly estimate the coefficients of the
nonlinear part. When trained on simple rules, we find that SVMs overfit only
weakly. The performance of SVMs is strongly enhanced, when the distribution of
the inputs has a gap in feature space.Comment: REVTeX, 4 pages, 2 figures, accepted by Phys. Rev. Lett (typos
corrected
Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity
Transcriptional dysregulation by mutant huntingtin (Htt) protein has been implicated in the pathogenesis of Huntington's disease (HD). We find that cultured cells expressing mutant Htt and striatal cells from HD transgenic mice have elevated nuclear factor-κB (NF-κB) activity. Furthermore, NF-κB is concentrated in the nucleus of neurons in the brains of HD transgenic mice. In inducible PC12 cells and in HD transgenic mice, mutant Htt activates the IκB kinase complex (IKK), a key regulator of NF-κB. Activation of IKK is likely mediated by direct interaction with mutant Htt, because the expanded polyglutamine stretch and adjacent proline-rich motifs in mutant Htt interact with IKKγ, a regulatory subunit of IKK. Activation of IKK may also influence the toxicity of mutant Htt, because expression of IKKγ promotes aggregation and nuclear localization of mutant Htt exon-1. Moreover, in acute striatal slice cultures, inhibition of IKK activity with an N-terminally truncated form of IKKγ blocks mutant Htt-induced toxicity in medium-sized spiny neurons (MSNs). In addition, blocking degradation of NF-κB inhibitors with a dominant-negative ubiquitin ligase β-transducin repeat-containing protein also reduces the toxicity of mutant Htt in MSNs. Therefore, aberrant NF-κB activation may contribute to the neurodegeneration induced by mutant Htt
Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features
BACKGROUND: The most prominent feature of melancholic depression is a near-total loss of the capacity to derive pleasure from activities or other positive stimuli. Additional symptoms can include psychomotor disturbances, anorexia, excessive guilt, and early awakening from sleep. Melancholic patients may exhibit treatment responses and outcomes that differ from those of non-melancholic patients. Pooled data from double-blind, placebo-controlled studies were utilized to compare the efficacy of duloxetine in depressed patients with and without melancholic features. METHODS: Efficacy data were pooled from 8 double-blind, placebo-controlled clinical trials of duloxetine. The presence of melancholic features (DSM-IV criteria) was determined using results from the Mini International Neuropsychiatric Interview (MINI). Patients (aged ≥ 18 years) meeting DSM-IV criteria for major depressive disorder (MDD) received duloxetine (40–120 mg/d; melancholic, N = 759; non-melancholic, N = 379) or placebo (melancholic, N = 519; non-melancholic, N = 256) for up to 9 weeks. Efficacy measures included the 17-item Hamilton Rating Scale for Depression (HAMD(17)) total score, HAMD(17 )subscales (Maier, anxiety, retardation, sleep), the Clinical Global Impression of Severity (CGI-S) and Patient Global Impression of Improvement (PGI-I) scales, and Visual Analog Scales (VAS) for pain. RESULTS: In data from all 8 studies, duloxetine's advantage over placebo did not differ significantly between melancholic and non-melancholic patients (treatment-by-melancholic status interactions were not statistically significant). Duloxetine demonstrated significantly greater improvement in depressive symptom severity, compared with placebo, within both melancholic and non-melancholic cohorts (p ≤ .001 for HAMD(17 )total score, CGI-S and PGI-I). When analyzed by gender, the magnitude of improvement in efficacy outcomes did not differ significantly between duloxetine-treated male and female melancholic patients. In the two studies that assessed duloxetine 60 mg once-daily dosing, duloxetine-treated melancholic patients had significantly greater improvement compared with placebo on HAMD(17 )total score, CGI-S, PGI-I, 3 of 4 subscales of the HAMD(17), and VAS overall pain severity (p < .01). Estimated probabilities of response and remission were significantly greater for melancholic patients receiving duloxetine 60 mg QD compared with placebo (response 74.7% vs. 42.2%, respectively, p < .001; remission 44.4% vs. 24.7%, respectively, p = .002 CONCLUSIONS: In this analysis of pooled data, the efficacy of duloxetine in patients with melancholic features did not differ significantly from that observed in non-melancholic patients
Correlated patterns in non-monotonic graded-response perceptrons
The optimal capacity of graded-response perceptrons storing biased and
spatially correlated patterns with non-monotonic input-output relations is
studied. It is shown that only the structure of the output patterns is
important for the overall performance of the perceptrons.Comment: 4 pages, 4 figure
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