Searching for new young stars in the northern hemisphere: The Pisces Moving Group

Using the kinematically unbiased technique described in Binks, Jeffries & Maxted (2015), we present optical spectra for a further 122 rapidly-rotating (rotation periods <6 days), X-ray active FGK stars, selected from the SuperWASP survey. We identify 17 new examples of young, probably single stars with ages of <200 Myr and provide additional evidence for a new northern hemisphere kinematic association: the Pisces Moving Group (MG). The group consists of 14 lithium-rich G- and K-type stars, that have a dispersion of only ∼3 km s−1 in each Galactic space velocity coordinate. The group members are approximately co-eval in the colour-magnitude diagram, with an age of 30–50 Myr, and have similar, though not identical, kinematics to the Octans-Near MG. stars: low-mass, stars: pre-main-sequenc

Virtual Human Project

This paper describes the development of a comprehensive human modeling environment, the Virtual Human, which will be used initially to model the human respiratory system for purposes of predicting pulmonary disease or injury using lung sounds. The details of the computational environment, including the development of a Virtual Human Thorax, a database for storing models, model parameters, and experimental data, and a Virtual Human web interface are outlined. Preliminary progress in developing this environment will be presented. A separate paper at the conference describes the modeling of sound generation using computational fluid dynamics and the modeling of sound propagation in the human respiratory system

Integrated and Sustainable Management of Post-industrial Coasts

The sustainable management of post-industrial coasts is a major emerging issue globally. Along such coasts, there may be a significant legacy of both contaminated land (including historic landfills and non-managed waste disposal) and contaminated sediments in and around urban and industrial areas, which require new strategies for cost-effective and integrated risk management under future sea-level rise and climate change scenarios. Here, we review current approaches to managing contamination in post-industrial coastlines, discuss emerging integrated management strategies (building on low input approaches to sustainable brownfields regeneration) and present an approach and framework for assessing and comparing different scenarios for coastal brownfield regeneration to soft re-use and other end-points. This framework can be applied to explore the opportunities for synergy and realization of wider environmental, economic and societal benefits between coastal protection, dredged material re-use and the management of brownfield land. As such, the approach we propose supports planning and options appraisal to realize maximum benefit and value from integrated coastal management strategies

Synergistic use of Sentinel-2 and UAV-derived data for plant fractional cover distribution mapping of coastal meadows with digital elevation models

Coastal wetlands provide a range of ecosystem services, yet they are currently under threat from global change impacts. Thus, their monitoring and assessment is vital for evaluating their status, extent and distribution. Remote sensing provides an excellent tool for evaluating coastal ecosystems, whether with small-scale studies using drones or national-/regional-/global-scale studies using satellite-derived data. This study used a fine-scale plant community classification of coastal meadows in Estonia derived from a multispectral camera on board unoccupied aerial vehicles (UAVs) to calculate the plant fractional cover (PFC) in Sentinel-2 MultiSpectral Instrument (MSI) sensor grids. A random forest (RF) algorithm was trained and tested with vegetation indices (VIs) calculated from the spectral bands extracted from the MSI sensor to predict the PFC. Additional RF models were trained and tested after adding a digital elevation model (DEM). After comparing the models, results show that using DEM with VIs can increase the prediction accuracy of PFC up to 2 times (R2 58%-70%). This suggests the use of ancillary data such as DEM to improve the prediction of empirical machine learning models, providing an appropriate approach to upscale local studies to wider areas for management and conservation purposes

Classification of Sharks in the Egyptian Mediterranean Waters Using Morphological and DNA Barcoding Approaches

The identification of species constitutes the first basic step in phylogenetic studies, biodiversity monitoring and conservation. DNA barcoding, i.e. the sequencing of a short standardized region of DNA, has been proposed as a new tool for animal species identification. The present study provides an update on the composition of shark in the Egyptian Mediterranean waters off Alexandria, since the latest study to date was performed 30 years ago, DNA barcoding was used in addition to classical taxonomical methodologies. Thus, 51 specimen were DNA barcoded for a 667 bp region of the mitochondrial COI gene. Although DNA barcoding aims at developing species identification systems, some phylogenetic signals were apparent in the data. In the neighbor-joining tree, 8 major clusters were apparent, each of them containing individuals belonging to the same species, and most with 100% bootstrap value. This study is the first to our knowledge to use DNA barcoding of the mitochondrial COI gene in order to confirm the presence of species Squalus acanthias, Oxynotus centrina, Squatina squatina, Scyliorhinus canicula, Scyliorhinus stellaris, Mustelus mustelus, Mustelus punctulatus and Carcharhinus altimus in the Egyptian Mediterranean waters. Finally, our study is the starting point of a new barcoding database concerning shark composition in the Egyptian Mediterranean waters (Barcoding of Egyptian Mediterranean Sharks [BEMS], http://www.boldsystems.org/views/projectlist.php?&#Barcoding%20Fish%20%28FishBOL%29)

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.

BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo. We performed this study to validate the model with representatives of all four classes of licensed antiretrovirals.Methodology/principal findingsEndpoint analyses for quantification of Thy/Liv implant viral load included ELISA for cell-associated p24, branched DNA assay for HIV-1 RNA, and detection of infected thymocytes by intracellular staining for Gag-p24. Antiviral protection from HIV-1-mediated thymocyte depletion was assessed by multicolor flow cytometric analysis of thymocyte subpopulations based on surface expression of CD3, CD4, and CD8. These mice can be productively infected with molecular clones of HIV-1 (e.g., the X4 clone NL4-3) as well as with primary R5 and R5X4 isolates. To determine whether results in this model are concordant with those found in humans, we performed direct comparisons of two drugs in the same class, each of which has known potency and dosing levels in humans. Here we show that second-generation antiretrovirals were, as expected, more potent than their first-generation predecessors: emtricitabine was more potent than lamivudine, efavirenz was more potent than nevirapine, and atazanavir was more potent than indinavir. After interspecies pharmacodynamic scaling, the dose ranges found to inhibit viral replication in the SCID-hu Thy/Liv mouse were similar to those used in humans. Moreover, HIV-1 replication in these mice was genetically stable; treatment of the mice with lamivudine did not result in the M184V substitution in reverse transcriptase, and the multidrug-resistant NY index case HIV-1 retained its drug-resistance substitutions.ConclusionGiven the fidelity of such comparisons, we conclude that this highly reproducible mouse model is likely to predict clinical antiviral efficacy in humans