Production Test Station Networking and Collection of Test Results

This thesis describes the installation of a network for all of the final test stations at the Industrial Systems Division of Texas Instruments in Johnson City, Tennessee. Once the network was installed, the project focused on the automatic collection of the test parameters for a centrallized database. The database was used to generate statistical data to determine if the manufacturing process were in control. If the process were not in control, then appropriate action was taken to prevent the particular unit from being tested. This provided a accurate and real-time analysis of how the manufacturing process was performing. Also, the automatic collection provided a means of studying how the manufacturing process performed over a period of time

Tyramine derivatives catalyze the aldol dimerization of butyraldehyde in the presence of E. coli

Biogenic amine organocatalysts have transformed the field of synthetic organic chemistry. Yet despite their use in synthesis and to label biomolecules in vitro, amine organocatalysis in vivo has received comparatively little attention – despite the potential of such reactions to be interfaced with living cells and to modify cellular metabolites. Herein we report that biogenic amines derived from L‐tyrosine catalyze the self‐aldol condensation of butanal to 2‐ethylhexenal – a key intermediate in the production of the bulk chemical 2‐ethylhexanol – in the presence of living Escherichia coli and outperform many amine organocatalysts currently used in synthetic organic chemistry. Furthermore, we demonstrate that cell lysate from E. coli and the prolific amine overproducer Corynebacterium glutamicum ATCC 13032 catalyze this reaction in vitro, demonstrating the potential for microbial metabolism to be used as a source of organocatalysts for biocompatible reactions in cells

Effect of Internal Control Systems on Implementation of Projects at County Government in Kenya

Over the years, there has being a problem of incorrect and unreliable financial record which has led to loss of organizational integrity, therefore affecting the implementation of projects in institutions and organizations. While financial management is a practically central concern in internal management of finances, its successful implementation remains an essential challenge for virtually any county government in developing counties. In situations where the environment is changing, the county itself is faced with a need to change. The fact that local authorities in Kenya were in transition following promulgation of the new constitutional dispensation, require an appropriate and detailed understanding on previous and existing financial challenges so that a new shift is established. This research was conducted in Nyamira County, Kenya which is amongst the 47 counties established in 2013. The study used explanatory survey design. The study used secondary data available at the county government databases..Data was analyzed using inferential statistic method of simple and multi variantregression analysis was used to determine the effect of internal control system on implementation of project at the county government. Results were presented in the form of tables for ease of interpretation. The study confirmed that internal control system has a significant effect on the implementation of projects at the county governments in Kenya. With adequate internal control measure in place at the county government then resources will be safeguarded and directed optimally to the right projects as planned

Palladium nanoparticles from desulfovibrio alaskensis G20 catalyze biocompatible sonogashira and biohydrogenation cascades

[Image: see text] Transition-metal nanoparticles produced by living bacteria are emerging as novel catalysts for sustainable synthesis. However, the scope of their catalytic activity and their ability to be integrated within metabolic pathways for the bioproduction of non-natural small molecules has been underexplored. Herein we report that Pd nanoparticles synthesized by the sulfate-reducing bacterium Desulfovibrio alaskensis G20 (DaPdNPs) catalyze the Sonogashira coupling of phenyl acetylenes and aryl iodides, and the subsequent one-pot hydrogenation to bibenzyl derivatives using hydrogen gas generated from d-glucose by engineered Escherichia coli DD-2. The formal hydroarylation reaction is biocompatible, occurs in aqueous media at ambient temperature, and affords products in 70–99% overall yield. This is the first reported microbial nanoparticle to catalyze the Sonogashira reaction and the first demonstration that these biogenic catalysts can be interfaced with the products of engineered metabolism for small molecule synthesis