2,071 research outputs found
Hydrogen Bonding and Molecular Geometry in Isolated Hydrates of 2-Ethylthiazole Characterised by Microwave Spectroscopy
Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk
The risk of developing type 2 diabetes mellitus (T2DM) is determined by a complex interplay involving lifestyle factors and genetic predisposition. Despite this, many studies do not consider the relative contributions of this complex array of factors to identify relationships which are important in progression or prevention of complex diseases. We aimed to describe the integrated effect of a number of lifestyle changes (weight, diet and physical activity) in the context of genetic susceptibility, on changes in glycaemic traits in overweight or obese participants following 12-months of a weight management programme. A sample of 353 participants from a behavioural weight management intervention were included in this study. A graphical Markov model was used to describe the impact of the intervention, by dividing the effects into various pathways comprising changes in proportion of dietary saturated fat, physical activity and weight loss, and a genetic predisposition score (T2DM-GPS), on changes in insulin sensitivity (HOMA-IR), insulin secretion (HOMA-B) and short and long term glycaemia (glucose and HbA1c). We demonstrated the use of graphical Markov modelling to identify the importance and interrelationships of a number of possible variables changed as a result of a lifestyle intervention, whilst considering fixed factors such as genetic predisposition, on changes in traits. Paths which led to weight loss and change in dietary saturated fat were important factors in the change of all glycaemic traits, whereas the T2DM-GPS only made a significant direct contribution to changes in HOMA-IR and plasma glucose after considering the effects of lifestyle factors. This analysis shows that modifiable factors relating to body weight, diet, and physical activity are more likely to impact on glycaemic traits than genetic predisposition during a behavioural intervention
Rural to Urban Migration and Changes in Cardiovascular risk Factors in Tanzania: A Prospective Cohort Study.
High levels of rural to urban migration are a feature of most African countries. Our aim was to investigate changes, and their determinants, in cardiovascular risk factors on rural to urban migration in Tanzania. Men and women (15 to 59 years) intending to migrate from Morogoro rural region to Dar es Salaam for at least 6 months were identified. Measurements were made at least one week but no more than one month prior to migration, and 1 to 3 monthly after migration. Outcome measures included body mass index, blood pressure, fasting lipids, and self reported physical activity and diet. One hundred and three men, 106 women, mean age 29 years, were recruited and 132 (63.2%) followed to 12 months. All the figures presented here refer to the difference between baseline and 12 months in these 132 individuals. Vigorous physical activity declined (79.4% to 26.5% in men, 37.8% to 15.6% in women, p < 0.001), and weight increased (2.30 kg men, 2.35 kg women, p < 0.001). Intake of red meat increased, but so did the intake of fresh fruit and vegetables. HDL cholesterol increased in men and women (0.24, 0.25 mmoll-1 respectively, p < 0.001); and in men, not women, total cholesterol increased (0.42 mmoll-1, p = 0.01), and triglycerides fell (0.31 mmoll-1, p = 0.034). Blood pressure appeared to fall in both men and women. For example, in men systolic blood pressure fell by 5.4 mmHg, p = 0.007, and in women by 8.6 mmHg, p = 0.001. The lower level of physical activity and increasing weight will increase the risk of diabetes and cardiovascular disease. However, changes in diet were mixed, and may have contributed to mixed changes in lipid profiles and a lack of rise in blood pressure. A better understanding of the changes occurring on rural to urban migration is needed to guide preventive measures
Emplacement of inflated Pāhoehoe flows in the Naude’s Nek Pass, Lesotho remnant, Karoo continental flood basalt province: use of flow-lobe tumuli in understanding flood basalt emplacement
Physical volcanological features are presented for a 710-m-thick section, of the Naude’s Nek Pass, within the lower part of the Lesotho remnant of the Karoo Large Igneous Province. The section consists of inflated pāhoehoe lava with thin, impersistent sedimentary interbeds towards the base. There are seven discreet packages of compound and hummocky pāhoehoe lobes containing flow-lobe tumuli, making up approximately 50% of the section. Approximately 45% of the sequence consists of 14 sheet lobes, between 10 and 52-m-thick. The majority of the sheet lobes are in two packages indicating prolonged periods of lava supply capable of producing thick sheet lobes. The other sheet lobes are as individual lobes or pairs, within compound flows, suggesting brief increases in lava supply rate. We suggest, contrary to current belief, that there is no evidence that compound flows are proximal to source and sheet lobes (simple flows) are distal to source and we propose that the presence of flow-lobe tumuli in compound flows could be an indicator that a flow is distal to source. We use detailed, previously published, studies of the Thakurvadi Formation (Deccan Traps) as an example. We show that the length of a lobe and therefore the sections that are ‘medial or distal to source’ are specific to each individual lobe and are dependent on the lava supply of each eruptive event, and as such flow lobe tumuli can be used as an indicator of relative distance from source
The contribution of microlensing surveys to the distance scale
In the early nineties several teams started large scale systematic surveys of
the Magellanic Clouds and the Galactic Bulge to search for microlensing
effects. As a by product, these groups have created enormous time-series
databases of photometric measurements of stars with a temporal sampling
duration and accuracy which are unprecedented. They provide the opportunity to
test the accuracy of primary distance indicators, such as Cepheids, RRLyrae
stars, the detached eclipsing binaries, or the luminosity of the red clump. We
will review the contribution of the microlensing surveys to the understanding
of the physics of the primary distance indicators, recent differential studies
and direct distance determinations to the Magellanic Clouds and the Galactic
Bulge.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in press. 21
pages; uses Kluwer's crckapb.sty LaTeX style file, enclose
Globular Cluster Distance Determinations
The present status of the distance scale to Galactic globular clusters is
reviewed. Six distance determination techniques which are deemed to be most
reliable are discussed in depth. These different techniques are used to
calibrate the absolute magnitude of the RR Lyrae stars. The various
calibrations fall into three groups. Main sequence fitting using Hipparcos
parallaxes, theoretical HB models and the RR Lyrae in the LMC all favor a
bright calibration, implying a `long' globular cluster distance scale. White
dwarf fitting and the astrometric distances yield a somewhat fainter RR Lyrae
calibration, while the statistical parallax solution yields faint RR Lyrae
stars implying a `short' distance scale to globular clusters. Various secondary
distance indicators discussed all favor the long distance scale. The `long' and
`short' distance scales differ by (0.31+/-0.16) mag. Averaging together all of
the different distance determinations yields Mv(RR) = (0.23+/-0.04)([Fe/H] +
1.6) + (0.56+/-0.12) mag.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in pres
R-process enrichment from a single event in an ancient dwarf galaxy
Elements heavier than zinc are synthesized through the (r)apid and (s)low
neutron-capture processes. The main site of production of the r-process
elements (such as europium) has been debated for nearly 60 years. Initial
studies of chemical abundance trends in old Milky Way halo stars suggested
continual r-process production, in sites like core-collapse supernovae. But
evidence from the local Universe favors r-process production mainly during rare
events, such as neutron star mergers. The appearance of a europium abundance
plateau in some dwarf spheroidal galaxies has been suggested as evidence for
rare r-process enrichment in the early Universe, but only under the assumption
of no gas accretion into the dwarf galaxies. Cosmologically motivated gas
accretion favors continual r-process enrichment in these systems. Furthermore,
the universal r-process pattern has not been cleanly identified in dwarf
spheroidals. The smaller, chemically simpler, and more ancient ultra-faint
dwarf galaxies assembled shortly after the first stars formed, and are ideal
systems with which to study nucleosynthesis events such as the r-process.
Reticulum II is one such galaxy. The abundances of non-neutron-capture elements
in this galaxy (and others like it) are similar to those of other old stars.
Here, we report that seven of nine stars in Reticulum II observed with
high-resolution spectroscopy show strong enhancements in heavy neutron-capture
elements, with abundances that follow the universal r-process pattern above
barium. The enhancement in this "r-process galaxy" is 2-3 orders of magnitude
higher than that detected in any other ultra-faint dwarf galaxy. This implies
that a single rare event produced the r-process material in Reticulum II. The
r-process yield and event rate are incompatible with ordinary core-collapse
supernovae, but consistent with other possible sites, such as neutron star
mergers.Comment: Published in Nature, 21 Mar 2016:
http://dx.doi.org/10.1038/nature1742
Successful closure of spontaneous esophageal rupture (Boerhaave’s syndrome) by endoscopic ligation with snare loops
Astronomical Spectroscopy
Spectroscopy is one of the most important tools that an astronomer has for
studying the universe. This chapter begins by discussing the basics, including
the different types of optical spectrographs, with extension to the ultraviolet
and the near-infrared. Emphasis is given to the fundamentals of how
spectrographs are used, and the trade-offs involved in designing an
observational experiment. It then covers observing and reduction techniques,
noting that some of the standard practices of flat-fielding often actually
degrade the quality of the data rather than improve it. Although the focus is
on point sources, spatially resolved spectroscopy of extended sources is also
briefly discussed. Discussion of differential extinction, the impact of
crowding, multi-object techniques, optimal extractions, flat-fielding
considerations, and determining radial velocities and velocity dispersions
provide the spectroscopist with the fundamentals needed to obtain the best
data. Finally the chapter combines the previous material by providing some
examples of real-life observing experiences with several typical instruments.Comment: An abridged version of a chapter to appear in Planets, Stars and
Stellar Systems, to be published in 2011 by Springer. Slightly revise
The blockchain: a new framework for robotic swarm systems
Swarms of robots will revolutionize many industrial applications, from targeted material delivery to precision farming. However, several of the heterogeneous characteristics that make them ideal for certain future applications --- robot autonomy, decentralized control, collective emergent behavior, etc. --- hinder the evolution of the technology from academic institutions to real-world problems. Blockchain, an emerging technology originated in the Bitcoin field, demonstrates that by combining peer-to-peer networks with cryptographic algorithms a group of agents can reach an agreement on a particular state of affairs and record that agreement without the need for a controlling authority. The combination of blockchain with other distributed systems, such as robotic swarm systems, can provide the necessary capabilities to make robotic swarm operations more secure, autonomous, flexible and even profitable. This work explains how blockchain technology can provide innovative solutions to four emergent issues in the swarm robotics research field. New security, decision making, behavior differentiation and business models for swarm robotic systems are described by providing case scenarios and examples. Finally, limitations and possible future problems that arise from the combination of these two technologies are described
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