An interstellar precursor mission

A mission out of the planetary system, with launch about the year 2000, could provide valuable scientific data as well as test some of the technology for a later mission to another star. Primary scientific objectives for the precursor mission concern characteristics of the heliopause, the interstellar medium, stellar distances (by parallax measurements), low energy cosmic rays, interplanetary gas distribution, and mass of the solar system. Secondary objectives include investigation of Pluto. Candidate science instruments are suggested. Individual spacecraft systems for the mission were considered, technology requirements and problem areas noted, and a number of recommendations made for technology study and advanced development. The most critical technology needs include attainment of 50-yr spacecraft lifetime and development of a long-life NEP system

The complete mitochondrial genome of the burrowing ghost shrimp, Nihonotrypaea harmandi (Bouvier, 1901), (Crustacea, Decapoda, Axiidea, Callianassidae) - a validation of the genus and species classifications

The complete mitochondrial genome of the burrowing ghost shrimp Nihonotrypaea harmandi wasreconstructed using the Illumina HiSeq platform. The genome was 15,272 bp in length made up of 37 mitochondrial genes (13 CDSs, 22 tRNAs, and 2 rRNAs) in the same order as other Nihonotrypaea species.Phylogenetic analyses suggested that Nihonotrypaea is a valid genus, and that N. harmandi can be phylogenetically marginally separated from N. japonica, though some authors considered the former as a synonym of the latte

Subnanotesla magnetometry with a fiber-coupled diamond sensor

Nitrogen-vacancy centers (NVCs) in diamond are being explored for future quantum technologies, and in particular ensembles of NVC are the basis for sensitive magnetometers. We present a fiber-coupled NVC magnetometer with an unshielded sensitivity of (310±20)pT/√Hz in the frequency range of 10–150 Hz at room temperature. This takes advantage of low-strain 12C diamond, lenses for fiber coupling and optimization of microwave modulation frequency, modulation amplitude, and power. Fiber coupling means the sensor can be conveniently brought within 2 mm of the object under study

Fundamental Studies Relating to Systems Analysis of Solid Propellants : Progress Report No. 5 - GALCIT 101, Subcontract No. RU- 293, October l, 1959-December 31, 1959

Previous reports of this series have attempted to define some of the important parameters affecting the structural integrity of solid propellant rocket grains. Three general areas have been discussed, namely material properties, analytical procedures, and criteria for mechanical failure. This particular report is devoted to a more detailed examination of the properties of a filled viscoelastic resin, and their representation by appropriate mechanical models. In addition, a comparison of two methods of computing viscoelastic strains in a pressurized cylinder is presented. In the category of material properties, linear viscoelastic model theory is reviewed, and certain important relations among sets of experimental data are deduced. A justification for the application of this theory is provided by the analytic representation of available dynamic data in terms of a well-known distribution function. Since the inception of this work additional experimental data on propellants has become available. In the category of analytical procedures, the usual approach of representing material properties by a four-element model, as determined from the dynamic data in a limited frequency range, is compared with the more sophisticated Fourier transform method in which the entire frequency range is utilized. The two approaches are applied to calculate the viscoelastic hoop strain at the inner boundary of an internally pressurized infinitely long hollow cylinder subjected to a ramp-type pressure pulse. In this example, the dilatation is assumed elastic or frequency independent and the distortion viscoelastic. In the following quarter, primary effort will be devoted to the determination of a criterion for mechanical failure of propellants. Two steps are involved. One is the analytical representation of ultimate strain as a function of temperature on strain rate by means of a mechanical model. In addition to the usual distribution of relaxation (or retardation) times, this model will be supplied with a distribution of ultimate strain. Step two involves the choice of a suitable criterion for compounding ultimate strain or ultimate stress components into a single parameter, which, when exceeded at a given rate and temperature, denotes the onset of fracture or mechanical failure

The architectures of translation : a magic carpet-ride through space and time (or, the awkward story of how we dis/placed Krisztina Tóth’s short fiction from Hungarian to English)

This interdisciplinary paper unfolds an account of a collaborative translation project, which draws on Ellen Eve Frank’s concept of “literary architecture” to propose a process of “architectural translation”. Our proposal is illustrated by a detailed account of our experiences translating the short fiction of contemporary Hungarian writer, Krisztina Tóth (b. 1967) into English. Staged as a journey through space, time and text, our enquiry frames the process in Barbara Godard’s terms as one of dis/placement, finding resonances with Rosi Braidotti’s nomadic subject and practices of feminist mimesis. Situating Tóth’s fiction in a European feminist literary heritage, we deploy a range of concepts drawn from translation, architecture, literary criticism and feminist philosophy to synthesise a translation strategy which engages the spatial, not only as a metaphor but a methodology for our project. In this account, we propose an architectural methodology as a tool for radical translators, and offer the process of translation as a way of thinking about internal and external spaces in postcolonial contexts

An open-source high-frequency lock-in amplifier

We present characterization of a lock-in amplifier based on a field programmable gate array capable of demodulation at up to 50 MHz. The system exhibits 90 nV/sqrt(Hz) of input noise at an optimum demodulation frequency of 500 kHz.The passband has a full-width half-maximum of 2.6 kHz for modulation frequencies above 100 kHz. Our code is opensource and operates on a commercially available platform

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes

Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extrachromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.This work was supported by the Tumorzentrum Heidelberg/Mannheim grant (D.10026941)and by March of Dimes Research Foundation grant #1-FY06-377 and NIH R01 GM069514