714 research outputs found
The East End, the West End and King's Cross: On clustering in the four-player Hotelling game.
Reply to comment by B. Andreotti et al. on "Solving the mystery of booming sand dunes"
This reply addresses three main issues raised in the
comment of Andreotti et al. [2008]. First, the turning of
ray paths in a granular material does not preclude the
propagation of body waves and the resonance condition
described by Vriend et al. [2007]. The waveguide model
still holds in the dune for the observed velocities, even
with a velocity increase with depth as implied by Andreotti
et al. [2008]. Secondly, the method of initiation of
spontaneous avalanching does not influence the booming
frequency. The frequency is independent of the source
once sustained booming starts; it depends on the subsurface
structure of the dune. Thirdly, if all data points from Vriend
et al. [2007] are included in the analysis (and not an
average or selection), no correlation is observed between
the sustained booming frequency and average particle
diameter
Solving the mystery of booming sand dunes
Desert booming can be heard after a natural slumping
event or during a sand avalanche generated by humans
sliding down the slip face of a large dune. The sound is
remarkable because it is composed of one dominant audible
frequency (70 to 105 Hz) plus several higher harmonics.
This study challenges earlier reports that the dunesā
frequency is a function of average grain size by
demonstrating through extensive field measurements that
the booming frequency results from a natural waveguide
associated with the dune. The booming frequency is fixed
by the depth of the surficial layer of dry loose sand that is
sandwiched between two regions of higher compressional
body wave velocity. This letter presents measurements of
the booming frequencies, compressional wave velocities,
depth of surficial layer, along with an analytical prediction
of the frequency based on constructive interference of
propagating waves generated by avalanching along the dune
surface
Traditional Biomolecular Structure Determination by NMR Spectroscopy Allows for Major Errors
One of the major goals of structural genomics projects is to determine the three-dimensional structure of representative members of as many different fold families as possible. Comparative modeling is expected to fill the remaining gaps by providing structural models of homologs of the experimentally determined proteins. However, for such an approach to be successful it is essential that the quality of the experimentally determined structures is adequate. In an attempt to build a homology model for the protein dynein light chain 2A (DLC2A) we found two potential templates, both experimentally determined nuclear magnetic resonance (NMR) structures originating from structural genomics efforts. Despite their high sequence identity (96%), the folds of the two structures are markedly different. This urged us to perform in-depth analyses of both structure ensembles and the deposited experimental data, the results of which clearly identify one of the two models as largely incorrect. Next, we analyzed the quality of a large set of recent NMR-derived structure ensembles originating from both structural genomics projects and individual structure determination groups. Unfortunately, a visual inspection of structures exhibiting lower quality scores than DLC2A reveals that the seriously flawed DLC2A structure is not an isolated incident. Overall, our results illustrate that the quality of NMR structures cannot be reliably evaluated using only traditional experimental input data and overall quality indicators as a reference and clearly demonstrate the urgent need for a tight integration of more sophisticated structure validation tools in NMR structure determination projects. In contrast to common methodologies where structures are typically evaluated as a whole, such tools should preferentially operate on a per-residue basis
Target and (Astro-)WISE technologies - Data federations and its applications
After its first implementation in 2003 the Astro-WISE technology has been
rolled out in several European countries and is used for the production of the
KiDS survey data. In the multi-disciplinary Target initiative this technology,
nicknamed WISE technology, has been further applied to a large number of
projects. Here, we highlight the data handling of other astronomical
applications, such as VLT-MUSE and LOFAR, together with some non-astronomical
applications such as the medical projects Lifelines and GLIMPS, the MONK
handwritten text recognition system, and business applications, by amongst
others, the Target Holding. We describe some of the most important lessons
learned and describe the application of the data-centric WISE type of approach
to the Science Ground Segment of the Euclid satellite.Comment: 9 pages, 5 figures, Proceedngs IAU Symposium No 325 Astroinformatics
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Process evaluation of TeamUp: a movement-based psychosocial intervention for refugee children in the Netherlands
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